Single cell type - DERA - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DERA
Gene descriptionⁱ Full gene name according to HGNC.	Deoxyribose-phosphate aldolase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Proximal tubular cells - Tubular reabsorption (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Proximal tubular cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Proximal tubular cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

DERA is part of cluster 67 Proximal tubular cells - Tubular reabsorption with confidenceⁱ 1
499 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TMEM252	Transmembrane protein 252	0.6562	67
SLC3A1	Solute carrier family 3 member 1	0.6538	67
CNDP2	Carnosine dipeptidase 2	0.6405	67
PBLD	Phenazine biosynthesis like protein domain containing	0.6139	67
MCUR1	Mitochondrial calcium uniporter regulator 1	0.6057	46
LYPLAL1	Lysophospholipase like 1	0.6057	67
CRYL1	Crystallin lambda 1	0.5891	67
SLC5A12	Solute carrier family 5 member 12	0.5731	67
BLOC1S5	Biogenesis of lysosomal organelles complex 1 subunit 5	0.5648	67
CUBN	Cubilin	0.5639	67
BCO1	Beta-carotene oxygenase 1	0.5633	21
GPD1	Glycerol-3-phosphate dehydrogenase 1	0.5619	67
RNF224	Ring finger protein 224	0.5588	67
SLC34A3	Solute carrier family 34 member 3	0.5536	67
MAOA	Monoamine oxidase A	0.5524	67

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	37.2 nTPM
Breast	40.0 nTPM
Adipose tissue	34.4 nTPM

Alveolar cells type 1	44.8 nTPM
Lung	44.8 nTPM

Alveolar cells type 2	28.4 nTPM
Lung	28.4 nTPM

Astrocytes	20.2 nTPM
Brain	20.2 nTPM

B-cells	19.4 nTPM
Liver	28.1 nTPM
Kidney	23.8 nTPM
Breast	21.3 nTPM
PBMC	20.0 nTPM
Stomach	19.1 nTPM
Spleen	19.0 nTPM
Bone marrow	16.4 nTPM
Colon	16.0 nTPM
Lymph node	15.3 nTPM
Adipose tissue	14.6 nTPM

Dendritic cells	22.1 nTPM
PBMC	27.9 nTPM
Breast	21.5 nTPM
Adipose tissue	17.0 nTPM

Endothelial cells	28.3 nTPM
Pancreas	38.6 nTPM
Placenta	35.8 nTPM
Lung	34.3 nTPM
Testis	32.9 nTPM
Ovary	30.3 nTPM
Esophagus	27.9 nTPM
Breast	27.6 nTPM
Liver	27.5 nTPM
Heart muscle	26.6 nTPM
Skin	26.6 nTPM
Skeletal muscle	25.8 nTPM
Endometrium	22.8 nTPM
Prostate	21.6 nTPM
Eye	17.8 nTPM

Fibroblasts	23.9 nTPM
Adipose tissue	45.7 nTPM
Skeletal muscle	31.6 nTPM
Breast	30.6 nTPM
Esophagus	28.6 nTPM
Skin	27.2 nTPM
Heart muscle	23.1 nTPM
Placenta	19.8 nTPM
Ovary	18.3 nTPM
Stomach	17.8 nTPM
Prostate	16.5 nTPM
Lung	3.4 nTPM

Intestinal goblet cells	44.7 nTPM
Small intestine	57.8 nTPM
Rectum	46.9 nTPM
Colon	29.3 nTPM

Macrophages	44.8 nTPM
PBMC	190.9 nTPM
Ovary	63.6 nTPM
Pancreas	51.0 nTPM
Prostate	40.1 nTPM
Testis	40.1 nTPM
Breast	35.9 nTPM
Adipose tissue	34.6 nTPM
Bone marrow	32.4 nTPM
Spleen	32.1 nTPM
Skeletal muscle	31.4 nTPM
Kidney	30.3 nTPM
Endometrium	27.0 nTPM
Esophagus	26.8 nTPM
Lung	24.2 nTPM
Stomach	11.7 nTPM

Paneth cells	49.6 nTPM
Small intestine	56.3 nTPM
Rectum	49.7 nTPM
Colon	42.8 nTPM

Plasma cells	30.7 nTPM
Bone marrow	51.1 nTPM
Spleen	44.0 nTPM
Stomach	26.9 nTPM
Esophagus	24.6 nTPM
Adipose tissue	7.0 nTPM

Respiratory ciliated cells	27.3 nTPM
Bronchus	31.3 nTPM
Lung	23.3 nTPM

Smooth muscle cells	27.5 nTPM
Ovary	62.0 nTPM
Pancreas	54.1 nTPM
Heart muscle	25.5 nTPM
Bronchus	25.3 nTPM
Skeletal muscle	24.8 nTPM
Adipose tissue	22.4 nTPM
Breast	20.0 nTPM
Esophagus	18.6 nTPM
Endometrium	17.6 nTPM
Skin	17.4 nTPM
Prostate	15.0 nTPM

T-cells	13.9 nTPM
Kidney	26.7 nTPM
Ovary	20.1 nTPM
Lung	19.7 nTPM
Liver	17.2 nTPM
Endometrium	14.9 nTPM
PBMC	14.8 nTPM
Breast	13.7 nTPM
Skeletal muscle	13.4 nTPM
Lymph node	13.2 nTPM
Bone marrow	13.2 nTPM
Spleen	12.1 nTPM
Stomach	11.2 nTPM
Skin	11.1 nTPM
Colon	10.0 nTPM
Adipose tissue	9.6 nTPM
Prostate	9.5 nTPM
Esophagus	6.6 nTPM

Basal respiratory cells	55.3 nTPM
Bronchus	55.3 nTPM

Cholangiocytes	27.1 nTPM
Liver	27.1 nTPM

Collecting duct cells	12.9 nTPM
Kidney	12.9 nTPM

Cytotrophoblasts	65.7 nTPM
Placenta	65.7 nTPM

Undifferentiated cells	42.9 nTPM
Small intestine	53.9 nTPM
Rectum	43.8 nTPM
Colon	31.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC