Single cell type - CNDP2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CNDP2
Gene descriptionⁱ Full gene name according to HGNC.	Carnosine dipeptidase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	18

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Proximal tubular cells - Tubular reabsorption (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Proximal enterocytes, Proximal tubular cells, Glandular and luminal cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (Karpas-707, RPMI-8226)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Proximal enterocytes, Proximal tubular cells, Glandular and luminal cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CNDP2 is part of cluster 67 Proximal tubular cells - Tubular reabsorption with confidenceⁱ 1
499 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TMEM252	Transmembrane protein 252	0.7682	67
SLC3A1	Solute carrier family 3 member 1	0.7419	67
SLC28A1	Solute carrier family 28 member 1	0.6985	67
GPD1	Glycerol-3-phosphate dehydrogenase 1	0.6922	67
AKR7A3	Aldo-keto reductase family 7 member A3	0.6867	67
FBP1	Fructose-bisphosphatase 1	0.6860	67
PEPD	Peptidase D	0.6813	67
RNF224	Ring finger protein 224	0.6730	67
ERICH4	Glutamate rich 4	0.6727	67
FAM151A	Family with sequence similarity 151 member A	0.6611	67
MAOA	Monoamine oxidase A	0.6607	67
SLC5A12	Solute carrier family 5 member 12	0.6597	67
KHK	Ketohexokinase	0.6579	67
DHDH	Dihydrodiol dehydrogenase	0.6514	67
SLC34A3	Solute carrier family 34 member 3	0.6478	67

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	39.2 nTPM
Breast	42.2 nTPM
Adipose tissue	36.2 nTPM

Alveolar cells type 1	73.7 nTPM
Lung	73.7 nTPM

Alveolar cells type 2	62.7 nTPM
Lung	62.7 nTPM

Astrocytes	16.6 nTPM
Brain	16.6 nTPM

B-cells	55.7 nTPM
Kidney	76.1 nTPM
PBMC	71.3 nTPM
Liver	64.3 nTPM
Bone marrow	62.1 nTPM
Colon	57.5 nTPM
Spleen	55.7 nTPM
Stomach	46.7 nTPM
Lymph node	44.8 nTPM
Adipose tissue	42.2 nTPM
Breast	36.0 nTPM

Dendritic cells	47.8 nTPM
PBMC	83.7 nTPM
Breast	31.3 nTPM
Adipose tissue	28.3 nTPM

Endothelial cells	49.6 nTPM
Eye	83.3 nTPM
Pancreas	69.5 nTPM
Testis	64.0 nTPM
Skeletal muscle	64.0 nTPM
Prostate	53.2 nTPM
Placenta	52.3 nTPM
Heart muscle	51.6 nTPM
Ovary	44.1 nTPM
Liver	41.2 nTPM
Lung	40.6 nTPM
Endometrium	40.3 nTPM
Esophagus	36.8 nTPM
Breast	35.2 nTPM
Skin	18.1 nTPM

Fibroblasts	23.5 nTPM
Placenta	35.6 nTPM
Stomach	26.7 nTPM
Ovary	26.6 nTPM
Skeletal muscle	25.8 nTPM
Esophagus	24.1 nTPM
Prostate	23.0 nTPM
Heart muscle	22.6 nTPM
Lung	22.4 nTPM
Adipose tissue	20.0 nTPM
Breast	17.4 nTPM
Skin	14.7 nTPM

Intestinal goblet cells	82.9 nTPM
Small intestine	120.1 nTPM
Rectum	73.6 nTPM
Colon	55.0 nTPM

Macrophages	79.0 nTPM
Ovary	153.6 nTPM
Pancreas	145.5 nTPM
Lung	95.4 nTPM
Spleen	94.3 nTPM
Prostate	91.7 nTPM
Kidney	91.5 nTPM
Testis	89.5 nTPM
Endometrium	71.8 nTPM
Bone marrow	71.2 nTPM
Esophagus	70.8 nTPM
Breast	64.0 nTPM
Adipose tissue	61.9 nTPM
Skeletal muscle	45.1 nTPM
Stomach	38.1 nTPM
PBMC	0.0 nTPM

Paneth cells	103.5 nTPM
Small intestine	146.4 nTPM
Colon	82.3 nTPM
Rectum	81.8 nTPM

Plasma cells	44.4 nTPM
Spleen	78.7 nTPM
Bone marrow	49.4 nTPM
Stomach	46.9 nTPM
Adipose tissue	28.5 nTPM
Esophagus	18.4 nTPM

Respiratory ciliated cells	73.3 nTPM
Bronchus	81.1 nTPM
Lung	65.6 nTPM

Smooth muscle cells	22.3 nTPM
Pancreas	55.3 nTPM
Ovary	32.9 nTPM
Bronchus	30.1 nTPM
Heart muscle	27.7 nTPM
Endometrium	23.5 nTPM
Skeletal muscle	19.0 nTPM
Prostate	17.8 nTPM
Breast	12.5 nTPM
Adipose tissue	12.2 nTPM
Skin	9.7 nTPM
Esophagus	4.6 nTPM

T-cells	38.2 nTPM
Kidney	71.8 nTPM
Endometrium	48.7 nTPM
Lung	47.1 nTPM
Liver	46.9 nTPM
PBMC	45.4 nTPM
Bone marrow	42.9 nTPM
Stomach	42.4 nTPM
Spleen	41.4 nTPM
Ovary	40.0 nTPM
Colon	39.5 nTPM
Prostate	37.9 nTPM
Lymph node	32.8 nTPM
Skeletal muscle	29.6 nTPM
Adipose tissue	25.7 nTPM
Breast	23.8 nTPM
Skin	21.2 nTPM
Esophagus	13.1 nTPM

Basal keratinocytes	9.2 nTPM
Skin	9.2 nTPM

Basal respiratory cells	48.6 nTPM
Bronchus	48.6 nTPM

Cholangiocytes	77.2 nTPM
Liver	77.2 nTPM

Collecting duct cells	119.5 nTPM
Kidney	119.5 nTPM

Undifferentiated cells	99.8 nTPM
Colon	117.3 nTPM
Small intestine	108.6 nTPM
Rectum	73.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC