Single cell type - UBR2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	UBR2
Gene descriptionⁱ Full gene name according to HGNC.	Ubiquitin protein ligase E3 component n-recognin 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Erythroid cells - Oxygen transport (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Inhibitory neurons, Excitatory neurons)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (neutrophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Inhibitory neurons, Excitatory neurons)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

UBR2 is part of cluster 6 Erythroid cells - Oxygen transport with confidenceⁱ 1
151 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
XRN1	5'-3' exoribonuclease 1	0.6091	59
RBM33	RNA binding motif protein 33	0.5192	52
TBCEL	Tubulin folding cofactor E like	0.4967	6
GAPVD1	GTPase activating protein and VPS9 domains 1	0.4878	10
ATG4A	Autophagy related 4A cysteine peptidase	0.4713	6
KIAA0232	KIAA0232	0.4692	6
FAM117A	Family with sequence similarity 117 member A	0.4678	6
CENPC	Centromere protein C	0.4507	24
MXI1	MAX interactor 1, dimerization protein	0.4499	53
ZNF805	Zinc finger protein 805	0.4447	52
OPA1	OPA1 mitochondrial dynamin like GTPase	0.4394	6
ABCB10	ATP binding cassette subfamily B member 10	0.4386	6
GDAP2	Ganglioside induced differentiation associated protein 2	0.4384	59
PPIP5K2	Diphosphoinositol pentakisphosphate kinase 2	0.4370	8
USP15	Ubiquitin specific peptidase 15	0.4347	19

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	33.5 nTPM
Adipose tissue	34.1 nTPM
Breast	32.9 nTPM

Alveolar cells type 1	16.0 nTPM
Lung	16.0 nTPM

Alveolar cells type 2	24.6 nTPM
Lung	24.6 nTPM

Astrocytes	82.6 nTPM
Brain	82.6 nTPM

B-cells	33.9 nTPM
Lymph node	60.3 nTPM
Bone marrow	49.8 nTPM
Adipose tissue	43.7 nTPM
Spleen	40.5 nTPM
Stomach	34.5 nTPM
Colon	33.5 nTPM
Breast	28.1 nTPM
PBMC	27.1 nTPM
Liver	16.5 nTPM
Kidney	4.8 nTPM

Dendritic cells	46.6 nTPM
Adipose tissue	65.0 nTPM
Breast	43.0 nTPM
PBMC	31.8 nTPM

Endothelial cells	24.8 nTPM
Heart muscle	41.1 nTPM
Skeletal muscle	38.3 nTPM
Endometrium	29.9 nTPM
Esophagus	29.5 nTPM
Liver	29.3 nTPM
Prostate	27.2 nTPM
Testis	26.1 nTPM
Breast	24.3 nTPM
Skin	22.5 nTPM
Lung	21.8 nTPM
Ovary	19.2 nTPM
Eye	15.4 nTPM
Pancreas	11.6 nTPM
Placenta	11.3 nTPM

Fibroblasts	26.5 nTPM
Heart muscle	40.9 nTPM
Skeletal muscle	36.5 nTPM
Adipose tissue	34.4 nTPM
Breast	30.5 nTPM
Esophagus	30.3 nTPM
Skin	24.7 nTPM
Prostate	23.2 nTPM
Lung	20.1 nTPM
Stomach	19.3 nTPM
Ovary	16.8 nTPM
Placenta	14.2 nTPM

Intestinal goblet cells	22.5 nTPM
Rectum	29.2 nTPM
Colon	23.5 nTPM
Small intestine	14.8 nTPM

Macrophages	26.1 nTPM
Skeletal muscle	36.1 nTPM
Stomach	35.1 nTPM
Adipose tissue	34.7 nTPM
Ovary	34.4 nTPM
Spleen	34.2 nTPM
Bone marrow	32.4 nTPM
Prostate	28.7 nTPM
Esophagus	28.3 nTPM
Breast	27.9 nTPM
Lung	27.5 nTPM
Endometrium	25.6 nTPM
Kidney	21.9 nTPM
Testis	19.7 nTPM
Pancreas	5.1 nTPM
PBMC	0.0 nTPM

Paneth cells	29.1 nTPM
Colon	39.6 nTPM
Rectum	25.4 nTPM
Small intestine	22.5 nTPM

Plasma cells	50.6 nTPM
Adipose tissue	80.1 nTPM
Stomach	58.3 nTPM
Bone marrow	41.2 nTPM
Esophagus	36.9 nTPM
Spleen	36.5 nTPM

Respiratory ciliated cells	27.9 nTPM
Bronchus	28.3 nTPM
Lung	27.7 nTPM

Smooth muscle cells	27.2 nTPM
Heart muscle	38.2 nTPM
Breast	32.8 nTPM
Skeletal muscle	32.4 nTPM
Endometrium	32.3 nTPM
Adipose tissue	29.9 nTPM
Bronchus	28.4 nTPM
Esophagus	26.4 nTPM
Prostate	26.3 nTPM
Ovary	23.4 nTPM
Skin	21.3 nTPM
Pancreas	8.5 nTPM

T-cells	44.0 nTPM
Adipose tissue	63.9 nTPM
Skeletal muscle	63.5 nTPM
Prostate	56.8 nTPM
Bone marrow	53.8 nTPM
Endometrium	49.7 nTPM
Ovary	46.7 nTPM
Colon	46.1 nTPM
Esophagus	45.9 nTPM
Spleen	44.4 nTPM
Breast	43.1 nTPM
Lymph node	41.8 nTPM
Lung	39.5 nTPM
Stomach	35.6 nTPM
Skin	35.4 nTPM
PBMC	34.5 nTPM
Liver	28.4 nTPM
Kidney	18.5 nTPM

Basal keratinocytes	16.6 nTPM
Skin	16.6 nTPM

Basal prostatic cells	18.1 nTPM
Prostate	18.1 nTPM

Basal respiratory cells	14.9 nTPM
Bronchus	14.9 nTPM

Basal squamous epithelial cells	28.5 nTPM
Esophagus	28.5 nTPM

Undifferentiated cells	21.5 nTPM
Rectum	26.1 nTPM
Small intestine	20.1 nTPM
Colon	18.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC