Single cell type - CENPC - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CENPC
Gene descriptionⁱ Full gene name according to HGNC.	Centromere protein C
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription regulation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CENPC is part of cluster 24 Non-specific - Transcription regulation with confidenceⁱ 1
415 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PHF3	PHD finger protein 3	0.6205	52
EPC1	Enhancer of polycomb homolog 1	0.5967	24
RBM33	RNA binding motif protein 33	0.5955	52
KAT6B	Lysine acetyltransferase 6B	0.5868	24
RGPD2	RANBP2 like and GRIP domain containing 2	0.5837	24
SMCHD1	Structural maintenance of chromosomes flexible hinge domain containing 1	0.5755	24
DDX24	DEAD-box helicase 24	0.5657	24
ICE1	Interactor of little elongation complex ELL subunit 1	0.5320	52
BCLAF1	BCL2 associated transcription factor 1	0.5320	52
ZDBF2	Zinc finger DBF-type containing 2	0.5311	40
BICDL1	BICD family like cargo adaptor 1	0.5254	24
ATF7IP	Activating transcription factor 7 interacting protein	0.5249	24
MIA3	MIA SH3 domain ER export factor 3	0.5242	52
MSL2	MSL complex subunit 2	0.5239	24
TSPYL2	TSPY like 2	0.5219	7

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	53.1 nTPM
Breast	54.1 nTPM
Adipose tissue	52.2 nTPM

Alveolar cells type 1	32.1 nTPM
Lung	32.1 nTPM

Alveolar cells type 2	35.5 nTPM
Lung	35.5 nTPM

Astrocytes	38.8 nTPM
Brain	38.8 nTPM

B-cells	68.4 nTPM
Adipose tissue	143.3 nTPM
Stomach	86.7 nTPM
Breast	85.6 nTPM
Lymph node	67.4 nTPM
Bone marrow	63.8 nTPM
Spleen	60.5 nTPM
PBMC	55.7 nTPM
Colon	54.3 nTPM
Kidney	47.6 nTPM
Liver	19.3 nTPM

Dendritic cells	75.0 nTPM
Adipose tissue	139.8 nTPM
Breast	69.2 nTPM
PBMC	16.0 nTPM

Endothelial cells	33.7 nTPM
Lung	74.8 nTPM
Heart muscle	63.8 nTPM
Skeletal muscle	52.2 nTPM
Endometrium	39.9 nTPM
Testis	35.6 nTPM
Breast	35.6 nTPM
Ovary	33.6 nTPM
Eye	29.9 nTPM
Esophagus	26.3 nTPM
Prostate	22.3 nTPM
Placenta	18.8 nTPM
Liver	16.5 nTPM
Skin	14.3 nTPM
Pancreas	7.7 nTPM

Fibroblasts	41.3 nTPM
Adipose tissue	68.2 nTPM
Breast	59.8 nTPM
Skeletal muscle	56.5 nTPM
Stomach	56.4 nTPM
Heart muscle	45.5 nTPM
Esophagus	40.9 nTPM
Lung	38.0 nTPM
Prostate	34.9 nTPM
Ovary	25.0 nTPM
Placenta	14.5 nTPM
Skin	14.3 nTPM

Intestinal goblet cells	18.4 nTPM
Colon	22.1 nTPM
Rectum	16.5 nTPM
Small intestine	16.4 nTPM

Macrophages	26.7 nTPM
Adipose tissue	61.8 nTPM
Breast	45.7 nTPM
Endometrium	42.0 nTPM
Skeletal muscle	38.9 nTPM
Testis	31.4 nTPM
Esophagus	25.2 nTPM
Ovary	24.8 nTPM
Stomach	23.5 nTPM
Lung	23.4 nTPM
Bone marrow	21.2 nTPM
Spleen	16.5 nTPM
Pancreas	15.3 nTPM
Kidney	15.2 nTPM
Prostate	15.0 nTPM
PBMC	0.0 nTPM

Paneth cells	13.0 nTPM
Rectum	14.7 nTPM
Colon	13.2 nTPM
Small intestine	11.3 nTPM

Plasma cells	89.1 nTPM
Adipose tissue	158.7 nTPM
Stomach	99.2 nTPM
Spleen	90.4 nTPM
Esophagus	49.4 nTPM
Bone marrow	47.7 nTPM

Respiratory ciliated cells	27.2 nTPM
Lung	39.4 nTPM
Bronchus	15.0 nTPM

Smooth muscle cells	34.2 nTPM
Heart muscle	71.7 nTPM
Skeletal muscle	54.5 nTPM
Adipose tissue	51.6 nTPM
Breast	47.6 nTPM
Endometrium	37.4 nTPM
Esophagus	29.4 nTPM
Ovary	25.5 nTPM
Prostate	20.9 nTPM
Skin	16.0 nTPM
Pancreas	13.4 nTPM
Bronchus	7.5 nTPM

T-cells	69.8 nTPM
Adipose tissue	163.3 nTPM
Breast	99.4 nTPM
Endometrium	97.8 nTPM
Prostate	85.2 nTPM
Stomach	81.6 nTPM
Skeletal muscle	77.9 nTPM
Colon	74.6 nTPM
Ovary	69.0 nTPM
Lymph node	64.3 nTPM
Spleen	61.7 nTPM
Bone marrow	55.0 nTPM
PBMC	54.7 nTPM
Kidney	48.0 nTPM
Lung	47.1 nTPM
Esophagus	39.3 nTPM
Liver	38.8 nTPM
Skin	29.0 nTPM

Basal prostatic cells	25.3 nTPM
Prostate	25.3 nTPM

Basal respiratory cells	17.7 nTPM
Bronchus	17.7 nTPM

Basal squamous epithelial cells	35.9 nTPM
Esophagus	35.9 nTPM

Cholangiocytes	18.6 nTPM
Liver	18.6 nTPM

Undifferentiated cells	16.4 nTPM
Colon	18.5 nTPM
Rectum	15.4 nTPM
Small intestine	15.2 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC