Single cell type - POU2F2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	POU2F2
Gene descriptionⁱ Full gene name according to HGNC.	POU class 2 homeobox 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	16

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	B-cells - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (B-cells, monocytes, Kupffer cells, Macrophages, Langerhans cells, Plasma cells, Spermatocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (non-classical monocyte)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (BJ hTERT+, Daudi, hTEC/SVTERT24-B, U-266/70, U-266/84, U-698, U-87 MG)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (B-cells, monocytes, Kupffer cells, Macrophages, Langerhans cells, Plasma cells, Spermatocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

POU2F2 is part of cluster 57 B-cells - Immune response with confidenceⁱ 1
204 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SCIMP	SLP adaptor and CSK interacting membrane protein	0.8605	57
NCF1	Neutrophil cytosolic factor 1	0.8591	57
CD37	CD37 molecule	0.8450	57
TLR6	Toll like receptor 6	0.8367	57
CD1D	CD1d molecule	0.8359	57
CR1	Complement C3b/C4b receptor 1 (Knops blood group)	0.8294	57
DOK3	Docking protein 3	0.7857	19
PTPN6	Protein tyrosine phosphatase non-receptor type 6	0.7829	57
RCSD1	RCSD domain containing 1	0.7817	57
SIGLEC10	Sialic acid binding Ig like lectin 10	0.7660	57
CD79B	CD79b molecule	0.7642	57
LYN	LYN proto-oncogene, Src family tyrosine kinase	0.7636	57
TLR10	Toll like receptor 10	0.7613	57
FCRLA	Fc receptor like A	0.7396	57
FCER2	Fc fragment of IgE receptor II	0.7368	57

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	2.7 nTPM
Breast	3.3 nTPM
Adipose tissue	2.2 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	7.0 nTPM
Lung	7.0 nTPM

Astrocytes	0.7 nTPM
Brain	0.7 nTPM

Basal keratinocytes	7.8 nTPM
Skin	7.8 nTPM

B-cells	225.5 nTPM
PBMC	388.2 nTPM
Bone marrow	318.8 nTPM
Lymph node	288.5 nTPM
Spleen	237.4 nTPM
Adipose tissue	220.0 nTPM
Stomach	199.3 nTPM
Colon	182.1 nTPM
Kidney	157.2 nTPM
Breast	139.2 nTPM
Liver	124.8 nTPM

Dendritic cells	29.3 nTPM
PBMC	59.8 nTPM
Adipose tissue	15.4 nTPM
Breast	12.8 nTPM

Endothelial cells	7.3 nTPM
Eye	56.7 nTPM
Breast	7.4 nTPM
Skin	6.8 nTPM
Liver	5.5 nTPM
Prostate	5.4 nTPM
Heart muscle	5.1 nTPM
Ovary	4.3 nTPM
Esophagus	3.6 nTPM
Skeletal muscle	3.2 nTPM
Endometrium	1.7 nTPM
Placenta	1.1 nTPM
Testis	0.6 nTPM
Lung	0.0 nTPM
Pancreas	0.0 nTPM

Fibroblasts	2.7 nTPM
Prostate	5.0 nTPM
Stomach	4.4 nTPM
Lung	3.4 nTPM
Esophagus	3.4 nTPM
Skin	3.0 nTPM
Breast	3.0 nTPM
Heart muscle	2.1 nTPM
Placenta	2.1 nTPM
Skeletal muscle	1.6 nTPM
Ovary	1.2 nTPM
Adipose tissue	0.3 nTPM

Intestinal goblet cells	1.6 nTPM
Colon	2.9 nTPM
Rectum	1.3 nTPM
Small intestine	0.8 nTPM

Macrophages	105.0 nTPM
Bone marrow	221.2 nTPM
Kidney	213.3 nTPM
Spleen	182.4 nTPM
Stomach	143.6 nTPM
Testis	142.3 nTPM
Skeletal muscle	137.2 nTPM
Adipose tissue	106.9 nTPM
Esophagus	89.7 nTPM
Ovary	87.4 nTPM
Breast	65.6 nTPM
Prostate	64.2 nTPM
Lung	51.5 nTPM
Endometrium	45.5 nTPM
PBMC	13.6 nTPM
Pancreas	10.2 nTPM

Paneth cells	0.1 nTPM
Rectum	0.4 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Plasma cells	96.7 nTPM
Bone marrow	126.9 nTPM
Esophagus	117.0 nTPM
Stomach	110.2 nTPM
Spleen	93.3 nTPM
Adipose tissue	36.1 nTPM

Respiratory ciliated cells	2.4 nTPM
Bronchus	3.3 nTPM
Lung	1.5 nTPM

Smooth muscle cells	5.0 nTPM
Pancreas	30.3 nTPM
Esophagus	4.6 nTPM
Skeletal muscle	4.3 nTPM
Breast	3.2 nTPM
Prostate	2.8 nTPM
Heart muscle	2.6 nTPM
Skin	1.8 nTPM
Bronchus	1.8 nTPM
Adipose tissue	1.8 nTPM
Endometrium	0.9 nTPM
Ovary	0.7 nTPM

Cone photoreceptor cells	6.2 nTPM
Eye	6.2 nTPM

Early spermatids	15.2 nTPM
Testis	15.2 nTPM

Excitatory neurons	19.7 nTPM
Brain	19.7 nTPM

T-cells	31.7 nTPM
PBMC	58.9 nTPM
Esophagus	58.9 nTPM
Lymph node	48.7 nTPM
Skeletal muscle	46.0 nTPM
Spleen	37.9 nTPM
Colon	33.7 nTPM
Bone marrow	33.7 nTPM
Kidney	29.4 nTPM
Breast	27.9 nTPM
Lung	27.4 nTPM
Liver	25.5 nTPM
Adipose tissue	25.4 nTPM
Stomach	22.1 nTPM
Prostate	19.0 nTPM
Endometrium	18.3 nTPM
Skin	14.3 nTPM
Ovary	11.1 nTPM

Undifferentiated cells	1.0 nTPM
Small intestine	1.2 nTPM
Colon	1.0 nTPM
Rectum	0.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC