Single cell type - BCLAF1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	BCLAF1
Gene descriptionⁱ Full gene name according to HGNC.	BCL2 associated transcription factor 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

BCLAF1 is part of cluster 52 Non-specific - Transcription with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
LRRC75A	Leucine rich repeat containing 75A	0.6349	24
PRRC2C	Proline rich coiled-coil 2C	0.6044	52
PRPF4B	Pre-mRNA processing factor 4B	0.6039	52
DDX24	DEAD-box helicase 24	0.5811	24
SMARCA5	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5	0.5556	11
BRD1	Bromodomain containing 1	0.5536	24
DDX5	DEAD-box helicase 5	0.5522	52
CRCP	CGRP receptor component	0.5495	52
RBM25	RNA binding motif protein 25	0.5474	52
SPTY2D1	SPT2 chromatin protein domain containing 1	0.5414	24
AKAP13	A-kinase anchoring protein 13	0.5408	65
RGPD5	RANBP2 like and GRIP domain containing 5	0.5385	52
CENPC	Centromere protein C	0.5320	24
KAT6B	Lysine acetyltransferase 6B	0.5285	24
SFSWAP	Splicing factor SWAP	0.5267	52

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	165.3 nTPM
Adipose tissue	201.2 nTPM
Breast	129.4 nTPM

Alveolar cells type 1	205.1 nTPM
Lung	205.1 nTPM

Alveolar cells type 2	178.7 nTPM
Lung	178.7 nTPM

Astrocytes	68.9 nTPM
Brain	68.9 nTPM

B-cells	174.3 nTPM
Adipose tissue	334.9 nTPM
Stomach	261.6 nTPM
Spleen	179.9 nTPM
Lymph node	178.4 nTPM
Colon	170.9 nTPM
Bone marrow	164.3 nTPM
PBMC	134.3 nTPM
Breast	127.1 nTPM
Liver	111.0 nTPM
Kidney	80.9 nTPM

Basal squamous epithelial cells	104.2 nTPM
Esophagus	104.2 nTPM

Dendritic cells	173.3 nTPM
Adipose tissue	307.6 nTPM
Breast	108.6 nTPM
PBMC	103.6 nTPM

Endothelial cells	117.5 nTPM
Skeletal muscle	195.9 nTPM
Endometrium	168.7 nTPM
Prostate	141.7 nTPM
Heart muscle	135.9 nTPM
Eye	133.5 nTPM
Lung	121.6 nTPM
Ovary	113.7 nTPM
Breast	113.6 nTPM
Testis	110.0 nTPM
Esophagus	109.5 nTPM
Liver	85.3 nTPM
Skin	84.9 nTPM
Placenta	72.7 nTPM
Pancreas	57.9 nTPM

Enteroendocrine cells	118.9 nTPM
Colon	145.7 nTPM
Rectum	92.2 nTPM

Erythroid cells	134.6 nTPM
Bone marrow	178.2 nTPM
Liver	90.9 nTPM

Fibroblasts	138.0 nTPM
Adipose tissue	209.3 nTPM
Lung	192.1 nTPM
Stomach	173.7 nTPM
Skeletal muscle	166.6 nTPM
Ovary	146.5 nTPM
Prostate	120.8 nTPM
Esophagus	120.3 nTPM
Breast	117.9 nTPM
Heart muscle	116.0 nTPM
Skin	78.1 nTPM
Placenta	76.6 nTPM

Intestinal goblet cells	106.0 nTPM
Colon	167.9 nTPM
Small intestine	78.9 nTPM
Rectum	71.1 nTPM

Macrophages	121.8 nTPM
Adipose tissue	268.4 nTPM
Lung	162.1 nTPM
Endometrium	161.6 nTPM
Skeletal muscle	156.5 nTPM
Spleen	155.5 nTPM
Bone marrow	118.7 nTPM
Prostate	114.6 nTPM
Testis	112.7 nTPM
Stomach	111.3 nTPM
Esophagus	102.2 nTPM
Breast	98.0 nTPM
Ovary	95.6 nTPM
Kidney	76.3 nTPM
Pancreas	66.4 nTPM
PBMC	27.3 nTPM

Paneth cells	81.4 nTPM
Small intestine	86.3 nTPM
Rectum	85.5 nTPM
Colon	72.5 nTPM

Plasma cells	197.8 nTPM
Adipose tissue	299.3 nTPM
Stomach	232.2 nTPM
Esophagus	160.2 nTPM
Spleen	155.3 nTPM
Bone marrow	141.8 nTPM

Cholangiocytes	65.8 nTPM
Liver	65.8 nTPM

Collecting duct cells	57.0 nTPM
Kidney	57.0 nTPM

Cone photoreceptor cells	210.6 nTPM
Eye	210.6 nTPM

Cytotrophoblasts	111.9 nTPM
Placenta	111.9 nTPM

Respiratory ciliated cells	147.1 nTPM
Lung	182.2 nTPM
Bronchus	112.0 nTPM

Smooth muscle cells	130.7 nTPM
Skeletal muscle	214.7 nTPM
Adipose tissue	177.1 nTPM
Bronchus	171.0 nTPM
Endometrium	145.2 nTPM
Prostate	142.3 nTPM
Heart muscle	131.0 nTPM
Breast	102.4 nTPM
Esophagus	99.2 nTPM
Ovary	94.6 nTPM
Pancreas	87.2 nTPM
Skin	73.6 nTPM

T-cells	174.8 nTPM
Adipose tissue	401.2 nTPM
Skeletal muscle	249.8 nTPM
Endometrium	239.7 nTPM
Stomach	237.0 nTPM
Colon	214.8 nTPM
Lung	173.1 nTPM
Prostate	156.3 nTPM
Lymph node	156.1 nTPM
Spleen	155.3 nTPM
PBMC	146.6 nTPM
Breast	143.1 nTPM
Bone marrow	132.4 nTPM
Ovary	126.8 nTPM
Liver	126.3 nTPM
Skin	115.1 nTPM
Esophagus	104.8 nTPM
Kidney	93.8 nTPM

Undifferentiated cells	101.6 nTPM
Colon	149.7 nTPM
Small intestine	82.4 nTPM
Rectum	72.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC