Single cell type - RABEP1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RABEP1
Gene descriptionⁱ Full gene name according to HGNC.	Rabaptin, RAB GTPase binding effector protein 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

RABEP1 is part of cluster 10 Non-specific - Unknown function with confidenceⁱ 1
482 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
POTEE	POTE ankyrin domain family member E	0.5231	10
ANP32D	Acidic nuclear phosphoprotein 32 family member D	0.5185	10
PITPNA	Phosphatidylinositol transfer protein alpha	0.4973	10
POTEF	POTE ankyrin domain family member F	0.4932	10
ETV3L	ETS variant transcription factor 3 like	0.4892	10
HNRNPCL2	Heterogeneous nuclear ribonucleoprotein C like 2	0.4891	10
UBE3A	Ubiquitin protein ligase E3A	0.4863	10
DNAJC19	DnaJ heat shock protein family (Hsp40) member C19	0.4758	39
NAA15	N-alpha-acetyltransferase 15, NatA auxiliary subunit	0.4685	10
ITIH6	Inter-alpha-trypsin inhibitor heavy chain family member 6	0.4684	35
CNOT4	CCR4-NOT transcription complex subunit 4	0.4674	10
ZMYND11	Zinc finger MYND-type containing 11	0.4671	10
NIPBL	NIPBL cohesin loading factor	0.4654	10
PPP1R2B	PPP1R2 family member B	0.4597	10
TOP2B	DNA topoisomerase II beta	0.4552	13

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	36.4 nTPM
Breast	37.5 nTPM
Adipose tissue	35.4 nTPM

Alveolar cells type 1	35.3 nTPM
Lung	35.3 nTPM

Alveolar cells type 2	45.1 nTPM
Lung	45.1 nTPM

Astrocytes	57.5 nTPM
Brain	57.5 nTPM

B-cells	53.8 nTPM
Adipose tissue	78.2 nTPM
PBMC	69.9 nTPM
Bone marrow	64.6 nTPM
Lymph node	55.8 nTPM
Stomach	54.0 nTPM
Colon	52.7 nTPM
Breast	50.9 nTPM
Spleen	48.8 nTPM
Kidney	33.4 nTPM
Liver	29.7 nTPM

Dendritic cells	47.2 nTPM
Adipose tissue	57.6 nTPM
PBMC	43.8 nTPM
Breast	40.1 nTPM

Endothelial cells	37.9 nTPM
Prostate	61.5 nTPM
Lung	59.3 nTPM
Heart muscle	58.5 nTPM
Endometrium	44.5 nTPM
Ovary	38.6 nTPM
Eye	36.4 nTPM
Breast	36.1 nTPM
Skeletal muscle	35.5 nTPM
Placenta	30.7 nTPM
Testis	29.0 nTPM
Skin	28.1 nTPM
Esophagus	26.7 nTPM
Pancreas	23.1 nTPM
Liver	22.9 nTPM

Fibroblasts	38.5 nTPM
Heart muscle	65.8 nTPM
Lung	64.8 nTPM
Prostate	52.8 nTPM
Skeletal muscle	35.9 nTPM
Ovary	35.7 nTPM
Adipose tissue	34.2 nTPM
Breast	32.4 nTPM
Skin	29.8 nTPM
Placenta	28.7 nTPM
Esophagus	23.8 nTPM
Stomach	19.3 nTPM

Intestinal goblet cells	17.1 nTPM
Small intestine	19.7 nTPM
Colon	17.2 nTPM
Rectum	14.4 nTPM

Macrophages	36.5 nTPM
Ovary	70.9 nTPM
Lung	59.9 nTPM
Spleen	44.6 nTPM
Prostate	38.9 nTPM
Kidney	37.8 nTPM
Testis	37.8 nTPM
Breast	37.7 nTPM
Adipose tissue	37.6 nTPM
Endometrium	36.6 nTPM
Skeletal muscle	33.5 nTPM
Pancreas	33.2 nTPM
Bone marrow	28.7 nTPM
Esophagus	22.0 nTPM
Stomach	14.7 nTPM
PBMC	13.6 nTPM

Paneth cells	65.5 nTPM
Colon	128.4 nTPM
Rectum	34.4 nTPM
Small intestine	33.8 nTPM

Plasma cells	28.2 nTPM
Adipose tissue	42.5 nTPM
Spleen	36.0 nTPM
Bone marrow	28.0 nTPM
Stomach	22.1 nTPM
Esophagus	12.3 nTPM

Respiratory ciliated cells	19.0 nTPM
Lung	26.2 nTPM
Bronchus	11.8 nTPM

Smooth muscle cells	47.7 nTPM
Bronchus	112.0 nTPM
Heart muscle	76.2 nTPM
Ovary	54.4 nTPM
Prostate	49.4 nTPM
Endometrium	44.0 nTPM
Skeletal muscle	34.6 nTPM
Pancreas	34.1 nTPM
Breast	34.1 nTPM
Skin	30.3 nTPM
Adipose tissue	29.0 nTPM
Esophagus	26.4 nTPM

T-cells	34.4 nTPM
Lung	51.6 nTPM
Adipose tissue	51.6 nTPM
PBMC	40.9 nTPM
Colon	39.9 nTPM
Skeletal muscle	39.1 nTPM
Breast	37.8 nTPM
Endometrium	37.0 nTPM
Liver	35.4 nTPM
Bone marrow	33.9 nTPM
Spleen	32.7 nTPM
Skin	32.6 nTPM
Lymph node	31.8 nTPM
Stomach	30.9 nTPM
Prostate	28.4 nTPM
Ovary	22.3 nTPM
Esophagus	19.7 nTPM
Kidney	18.5 nTPM

Basal keratinocytes	24.0 nTPM
Skin	24.0 nTPM

Basal prostatic cells	30.1 nTPM
Prostate	30.1 nTPM

Basal respiratory cells	17.0 nTPM
Bronchus	17.0 nTPM

Basal squamous epithelial cells	25.6 nTPM
Esophagus	25.6 nTPM

Undifferentiated cells	18.9 nTPM
Colon	21.5 nTPM
Rectum	18.7 nTPM
Small intestine	16.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC