Single cell type - FAM13B - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FAM13B
Gene descriptionⁱ Full gene name according to HGNC.	Family with sequence similarity 13 member B
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Oligodendrocytes, Excitatory neurons, Inhibitory neurons, Oligodendrocyte precursor cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Oligodendrocytes, Excitatory neurons, Inhibitory neurons, Oligodendrocyte precursor cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

FAM13B is part of cluster 59 Non-specific - Transcription with confidenceⁱ 1
354 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SLC25A32	Solute carrier family 25 member 32	0.6845	59
INTS9	Integrator complex subunit 9	0.6226	59
MAPRE2	Microtubule associated protein RP/EB family member 2	0.6177	42
RNF111	Ring finger protein 111	0.5911	59
ZNF490	Zinc finger protein 490	0.5884	59
ASTL	Astacin like metalloendopeptidase	0.5826	59
ZNF10	Zinc finger protein 10	0.5815	59
CNOT2	CCR4-NOT transcription complex subunit 2	0.5749	44
RIC1	RIC1 homolog, RAB6A GEF complex partner 1	0.5712	57
KDM6A	Lysine demethylase 6A	0.5685	44
SSH2	Slingshot protein phosphatase 2	0.5683	59
RLF	RLF zinc finger	0.5678	44
TAF4B	TATA-box binding protein associated factor 4b	0.5621	59
ZNF484	Zinc finger protein 484	0.5584	59
MAP2K4	Mitogen-activated protein kinase kinase 4	0.5557	21

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	21.2 nTPM
Adipose tissue	23.6 nTPM
Breast	18.9 nTPM

Alveolar cells type 1	22.4 nTPM
Lung	22.4 nTPM

Alveolar cells type 2	19.8 nTPM
Lung	19.8 nTPM

Astrocytes	63.6 nTPM
Brain	63.6 nTPM

B-cells	56.7 nTPM
Lymph node	121.1 nTPM
Stomach	99.0 nTPM
Spleen	90.0 nTPM
Bone marrow	76.8 nTPM
Adipose tissue	49.1 nTPM
Colon	41.5 nTPM
PBMC	34.3 nTPM
Breast	33.4 nTPM
Kidney	14.3 nTPM
Liver	7.7 nTPM

Dendritic cells	44.9 nTPM
Adipose tissue	58.0 nTPM
Breast	48.8 nTPM
PBMC	27.9 nTPM

Endothelial cells	17.8 nTPM
Endometrium	32.1 nTPM
Esophagus	30.4 nTPM
Skeletal muscle	24.5 nTPM
Skin	21.5 nTPM
Heart muscle	19.3 nTPM
Lung	18.7 nTPM
Testis	17.7 nTPM
Breast	16.8 nTPM
Prostate	16.0 nTPM
Ovary	13.9 nTPM
Liver	12.8 nTPM
Placenta	9.1 nTPM
Eye	8.9 nTPM
Pancreas	7.7 nTPM

Fibroblasts	21.7 nTPM
Lung	33.5 nTPM
Esophagus	32.3 nTPM
Skeletal muscle	28.6 nTPM
Stomach	26.7 nTPM
Skin	24.0 nTPM
Heart muscle	18.6 nTPM
Breast	18.3 nTPM
Prostate	16.9 nTPM
Ovary	14.8 nTPM
Adipose tissue	14.8 nTPM
Placenta	10.0 nTPM

Intestinal goblet cells	9.9 nTPM
Colon	12.1 nTPM
Rectum	10.6 nTPM
Small intestine	7.1 nTPM

Macrophages	31.2 nTPM
Stomach	52.7 nTPM
Esophagus	50.4 nTPM
Bone marrow	46.2 nTPM
Skeletal muscle	43.7 nTPM
Adipose tissue	43.6 nTPM
Spleen	39.4 nTPM
Endometrium	37.6 nTPM
Breast	30.3 nTPM
Lung	28.8 nTPM
Kidney	24.2 nTPM
Ovary	21.5 nTPM
Testis	17.4 nTPM
Prostate	16.0 nTPM
PBMC	13.6 nTPM
Pancreas	2.5 nTPM

Paneth cells	7.0 nTPM
Small intestine	15.0 nTPM
Rectum	6.1 nTPM
Colon	0.0 nTPM

Plasma cells	37.5 nTPM
Adipose tissue	69.0 nTPM
Stomach	38.3 nTPM
Esophagus	30.7 nTPM
Spleen	26.7 nTPM
Bone marrow	23.0 nTPM

Respiratory ciliated cells	12.9 nTPM
Lung	13.1 nTPM
Bronchus	12.6 nTPM

Smooth muscle cells	24.8 nTPM
Esophagus	48.0 nTPM
Endometrium	38.0 nTPM
Heart muscle	34.7 nTPM
Skin	26.5 nTPM
Adipose tissue	24.7 nTPM
Ovary	24.0 nTPM
Skeletal muscle	22.8 nTPM
Breast	21.6 nTPM
Prostate	18.7 nTPM
Bronchus	8.6 nTPM
Pancreas	5.1 nTPM

T-cells	46.9 nTPM
Esophagus	91.7 nTPM
Lymph node	85.8 nTPM
Stomach	73.8 nTPM
Spleen	65.0 nTPM
Adipose tissue	61.7 nTPM
Skeletal muscle	55.5 nTPM
Endometrium	54.1 nTPM
Lung	45.6 nTPM
Bone marrow	45.4 nTPM
Breast	45.4 nTPM
Colon	33.2 nTPM
Skin	33.2 nTPM
PBMC	26.6 nTPM
Ovary	22.3 nTPM
Liver	20.8 nTPM
Prostate	19.0 nTPM
Kidney	17.8 nTPM

Basal keratinocytes	15.4 nTPM
Skin	15.4 nTPM

Basal prostatic cells	15.7 nTPM
Prostate	15.7 nTPM

Basal squamous epithelial cells	64.9 nTPM
Esophagus	64.9 nTPM

Collecting duct cells	5.5 nTPM
Kidney	5.5 nTPM

Undifferentiated cells	8.4 nTPM
Rectum	9.4 nTPM
Small intestine	9.2 nTPM
Colon	6.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC