Single cell type - KDM6A - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	KDM6A
Gene descriptionⁱ Full gene name according to HGNC.	Lysine demethylase 6A
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Enzymes Human disease related genes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	11

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Endometrium - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Oligodendrocytes, Oligodendrocyte precursor cells, Microglial cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Oligodendrocytes, Oligodendrocyte precursor cells, Microglial cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

KDM6A is part of cluster 44 Endometrium - Transcription with confidenceⁱ 1
491 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CDKAL1	CDK5 regulatory subunit associated protein 1 like 1	0.6281	42
ZNF644	Zinc finger protein 644	0.5901	44
CNOT2	CCR4-NOT transcription complex subunit 2	0.5789	44
FAM13B	Family with sequence similarity 13 member B	0.5685	59
RLF	RLF zinc finger	0.5505	44
SCAF8	SR-related CTD associated factor 8	0.5424	42
RAD51B	RAD51 paralog B	0.5412	42
ARAP2	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	0.5347	42
DYRK1A	Dual specificity tyrosine phosphorylation regulated kinase 1A	0.5311	44
PPP1R16B	Protein phosphatase 1 regulatory subunit 16B	0.5307	59
PDE4B	Phosphodiesterase 4B	0.5209	42
ARIH1	Ariadne RBR E3 ubiquitin protein ligase 1	0.5110	7
MON2	MON2 homolog, regulator of endosome-to-Golgi trafficking	0.5100	42
ZNF155	Zinc finger protein 155	0.5022	21
UBR5	Ubiquitin protein ligase E3 component n-recognin 5	0.4889	44

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	23.2 nTPM
Adipose tissue	29.9 nTPM
Breast	16.6 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	10.6 nTPM
Lung	10.6 nTPM

Astrocytes	92.1 nTPM
Brain	92.1 nTPM

B-cells	26.0 nTPM
Lymph node	59.2 nTPM
Adipose tissue	45.2 nTPM
Stomach	43.2 nTPM
Spleen	36.4 nTPM
Breast	28.1 nTPM
Bone marrow	27.0 nTPM
Colon	6.4 nTPM
Liver	5.5 nTPM
Kidney	4.8 nTPM
PBMC	4.3 nTPM

Dendritic cells	26.1 nTPM
Adipose tissue	50.3 nTPM
Breast	24.1 nTPM
PBMC	4.0 nTPM

Endothelial cells	13.1 nTPM
Endometrium	29.2 nTPM
Esophagus	22.2 nTPM
Skeletal muscle	19.2 nTPM
Heart muscle	16.3 nTPM
Lung	15.6 nTPM
Breast	13.9 nTPM
Ovary	13.8 nTPM
Skin	13.0 nTPM
Prostate	10.9 nTPM
Testis	10.4 nTPM
Liver	8.2 nTPM
Placenta	4.0 nTPM
Pancreas	3.9 nTPM
Eye	3.3 nTPM

Fibroblasts	14.2 nTPM
Heart muscle	29.5 nTPM
Adipose tissue	19.8 nTPM
Skeletal muscle	17.8 nTPM
Esophagus	17.7 nTPM
Skin	14.6 nTPM
Breast	13.4 nTPM
Ovary	11.0 nTPM
Prostate	10.1 nTPM
Stomach	8.9 nTPM
Placenta	7.5 nTPM
Lung	5.6 nTPM

Intestinal goblet cells	14.0 nTPM
Rectum	17.0 nTPM
Small intestine	12.9 nTPM
Colon	12.1 nTPM

Macrophages	19.9 nTPM
Adipose tissue	45.2 nTPM
Skeletal muscle	29.5 nTPM
Stomach	23.5 nTPM
Endometrium	23.2 nTPM
Bone marrow	22.5 nTPM
Ovary	22.4 nTPM
Esophagus	22.0 nTPM
Spleen	21.8 nTPM
Breast	20.7 nTPM
Testis	14.0 nTPM
Prostate	13.8 nTPM
PBMC	13.6 nTPM
Lung	10.0 nTPM
Kidney	8.3 nTPM
Pancreas	7.7 nTPM

Paneth cells	17.4 nTPM
Small intestine	26.3 nTPM
Rectum	15.9 nTPM
Colon	9.9 nTPM

Plasma cells	31.4 nTPM
Adipose tissue	59.4 nTPM
Esophagus	43.0 nTPM
Stomach	21.5 nTPM
Spleen	19.8 nTPM
Bone marrow	13.2 nTPM

Respiratory ciliated cells	8.9 nTPM
Bronchus	12.0 nTPM
Lung	5.8 nTPM

Smooth muscle cells	17.0 nTPM
Ovary	41.2 nTPM
Endometrium	24.2 nTPM
Adipose tissue	22.2 nTPM
Esophagus	20.1 nTPM
Heart muscle	17.2 nTPM
Skeletal muscle	13.7 nTPM
Breast	12.0 nTPM
Skin	11.9 nTPM
Bronchus	11.4 nTPM
Prostate	9.7 nTPM
Pancreas	3.1 nTPM

T-cells	27.4 nTPM
Adipose tissue	52.9 nTPM
Lymph node	52.5 nTPM
Endometrium	50.0 nTPM
Esophagus	39.3 nTPM
Stomach	36.9 nTPM
Spleen	35.2 nTPM
Breast	33.0 nTPM
Skeletal muscle	27.6 nTPM
Colon	24.2 nTPM
Bone marrow	22.7 nTPM
Prostate	19.0 nTPM
Skin	16.6 nTPM
Ovary	15.6 nTPM
PBMC	11.4 nTPM
Lung	10.6 nTPM
Kidney	9.6 nTPM
Liver	8.2 nTPM

Basal prostatic cells	14.3 nTPM
Prostate	14.3 nTPM

Basal respiratory cells	9.4 nTPM
Bronchus	9.4 nTPM

Basal squamous epithelial cells	38.1 nTPM
Esophagus	38.1 nTPM

Cholangiocytes	12.8 nTPM
Liver	12.8 nTPM

Undifferentiated cells	13.1 nTPM
Rectum	15.2 nTPM
Colon	15.0 nTPM
Small intestine	9.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC