Single cell type - UBA6 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	UBA6
Gene descriptionⁱ Full gene name according to HGNC.	Ubiquitin like modifier activating enzyme 6
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Epithelial cell types - Mixed function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

UBA6 is part of cluster 22 Epithelial cell types - Mixed function with confidenceⁱ 1
298 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CCNT2	Cyclin T2	0.6836	52
RNF169	Ring finger protein 169	0.6333	52
FNBP4	Formin binding protein 4	0.6257	52
PLEKHN1	Pleckstrin homology domain containing N1	0.6067	22
GAN	Gigaxonin	0.6047	22
TXNRD1	Thioredoxin reductase 1	0.5933	22
ZNF562	Zinc finger protein 562	0.5892	22
ZNF207	Zinc finger protein 207	0.5874	52
SMAD3	SMAD family member 3	0.5755	22
ITGA2	Integrin subunit alpha 2	0.5715	22
ZNF83	Zinc finger protein 83	0.5714	52
TMEM41B	Transmembrane protein 41B	0.5691	44
PSME4	Proteasome activator subunit 4	0.5684	44
MYO6	Myosin VI	0.5657	22
ZNF430	Zinc finger protein 430	0.5571	52

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	34.6 nTPM
Adipose tissue	47.6 nTPM
Breast	21.5 nTPM

Alveolar cells type 1	25.6 nTPM
Lung	25.6 nTPM

Alveolar cells type 2	21.7 nTPM
Lung	21.7 nTPM

Astrocytes	54.5 nTPM
Brain	54.5 nTPM

B-cells	46.5 nTPM
Colon	70.3 nTPM
Adipose tissue	64.1 nTPM
Kidney	57.1 nTPM
Stomach	47.7 nTPM
Bone marrow	47.4 nTPM
Spleen	47.1 nTPM
Lymph node	41.4 nTPM
PBMC	40.0 nTPM
Breast	25.5 nTPM
Liver	24.1 nTPM

Dendritic cells	45.0 nTPM
Adipose tissue	59.2 nTPM
PBMC	47.8 nTPM
Breast	28.1 nTPM

Endothelial cells	39.0 nTPM
Prostate	118.1 nTPM
Skin	51.0 nTPM
Skeletal muscle	43.3 nTPM
Ovary	42.3 nTPM
Endometrium	40.7 nTPM
Heart muscle	39.3 nTPM
Lung	37.4 nTPM
Esophagus	29.3 nTPM
Eye	28.3 nTPM
Pancreas	27.0 nTPM
Testis	25.8 nTPM
Placenta	23.9 nTPM
Breast	22.1 nTPM
Liver	17.4 nTPM

Fibroblasts	26.6 nTPM
Skin	36.3 nTPM
Ovary	35.8 nTPM
Prostate	34.9 nTPM
Skeletal muscle	31.8 nTPM
Lung	31.3 nTPM
Adipose tissue	23.8 nTPM
Placenta	22.6 nTPM
Esophagus	19.8 nTPM
Breast	19.8 nTPM
Heart muscle	19.0 nTPM
Stomach	17.8 nTPM

Intestinal goblet cells	27.0 nTPM
Colon	30.0 nTPM
Small intestine	26.8 nTPM
Rectum	24.1 nTPM

Macrophages	31.4 nTPM
Adipose tissue	56.7 nTPM
Prostate	44.7 nTPM
Skeletal muscle	43.4 nTPM
Lung	39.8 nTPM
Spleen	36.3 nTPM
Stomach	35.1 nTPM
Ovary	30.5 nTPM
Kidney	30.3 nTPM
Pancreas	28.0 nTPM
Endometrium	27.0 nTPM
Esophagus	26.8 nTPM
Bone marrow	26.2 nTPM
Breast	24.0 nTPM
Testis	22.6 nTPM
PBMC	0.0 nTPM

Paneth cells	36.6 nTPM
Colon	65.8 nTPM
Small intestine	22.5 nTPM
Rectum	21.4 nTPM

Plasma cells	44.8 nTPM
Adipose tissue	85.8 nTPM
Spleen	37.4 nTPM
Esophagus	36.9 nTPM
Stomach	34.4 nTPM
Bone marrow	29.7 nTPM

Respiratory ciliated cells	34.9 nTPM
Bronchus	42.0 nTPM
Lung	27.7 nTPM

Smooth muscle cells	24.0 nTPM
Ovary	40.7 nTPM
Prostate	38.8 nTPM
Skeletal muscle	31.3 nTPM
Adipose tissue	29.0 nTPM
Pancreas	26.7 nTPM
Endometrium	25.5 nTPM
Skin	22.3 nTPM
Breast	15.8 nTPM
Heart muscle	15.4 nTPM
Bronchus	12.2 nTPM
Esophagus	6.2 nTPM

T-cells	37.6 nTPM
Colon	71.7 nTPM
Adipose tissue	58.5 nTPM
Prostate	47.3 nTPM
Skin	44.7 nTPM
Endometrium	42.6 nTPM
Skeletal muscle	41.3 nTPM
Bone marrow	37.9 nTPM
PBMC	34.8 nTPM
Stomach	34.4 nTPM
Spleen	34.2 nTPM
Kidney	31.5 nTPM
Breast	30.6 nTPM
Liver	29.9 nTPM
Esophagus	26.2 nTPM
Lymph node	26.1 nTPM
Ovary	24.5 nTPM
Lung	22.8 nTPM

Basal keratinocytes	70.1 nTPM
Skin	70.1 nTPM

Basal prostatic cells	65.2 nTPM
Prostate	65.2 nTPM

Basal respiratory cells	43.0 nTPM
Bronchus	43.0 nTPM

Basal squamous epithelial cells	37.5 nTPM
Esophagus	37.5 nTPM

Undifferentiated cells	22.8 nTPM
Colon	28.4 nTPM
Rectum	21.0 nTPM
Small intestine	19.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC