Single cell type - CCNT2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CCNT2
Gene descriptionⁱ Full gene name according to HGNC.	Cyclin T2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CCNT2 is part of cluster 52 Non-specific - Transcription with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
FNBP4	Formin binding protein 4	0.7246	52
UBA6	Ubiquitin like modifier activating enzyme 6	0.6836	22
SRSF11	Serine and arginine rich splicing factor 11	0.5982	52
ZFC3H1	Zinc finger C3H1-type containing	0.5837	44
DMTF1	Cyclin D binding myb like transcription factor 1	0.5746	52
SMC5	Structural maintenance of chromosomes 5	0.5716	52
ARGLU1	Arginine and glutamate rich 1	0.5421	52
RNF169	Ring finger protein 169	0.5255	52
ZNF644	Zinc finger protein 644	0.5243	44
ASH1L	ASH1 like histone lysine methyltransferase	0.5194	52
USP6NL	USP6 N-terminal like	0.5185	44
PKN2	Protein kinase N2	0.5135	52
CCNK	Cyclin K	0.5074	44
PRDM2	PR/SET domain 2	0.4974	57
MYSM1	Myb like, SWIRM and MPN domains 1	0.4962	52

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	27.1 nTPM
Adipose tissue	31.2 nTPM
Breast	23.0 nTPM

Alveolar cells type 1	25.6 nTPM
Lung	25.6 nTPM

Alveolar cells type 2	26.0 nTPM
Lung	26.0 nTPM

Astrocytes	49.6 nTPM
Brain	49.6 nTPM

B-cells	38.0 nTPM
Stomach	71.3 nTPM
Bone marrow	53.2 nTPM
Adipose tissue	47.1 nTPM
Spleen	42.2 nTPM
Breast	40.2 nTPM
Lymph node	39.7 nTPM
Colon	33.5 nTPM
PBMC	21.4 nTPM
Kidney	19.0 nTPM
Liver	12.2 nTPM

Dendritic cells	35.3 nTPM
Adipose tissue	49.6 nTPM
Breast	36.4 nTPM
PBMC	20.0 nTPM

Endothelial cells	21.5 nTPM
Heart muscle	39.7 nTPM
Lung	34.3 nTPM
Endometrium	31.6 nTPM
Prostate	30.8 nTPM
Ovary	26.3 nTPM
Eye	21.8 nTPM
Skeletal muscle	20.1 nTPM
Testis	19.0 nTPM
Breast	18.6 nTPM
Esophagus	16.9 nTPM
Liver	16.5 nTPM
Placenta	13.7 nTPM
Skin	12.0 nTPM
Pancreas	0.0 nTPM

Fibroblasts	23.7 nTPM
Stomach	34.1 nTPM
Prostate	31.8 nTPM
Lung	30.1 nTPM
Adipose tissue	27.5 nTPM
Heart muscle	24.5 nTPM
Breast	23.0 nTPM
Skeletal muscle	22.4 nTPM
Esophagus	20.1 nTPM
Ovary	19.9 nTPM
Skin	14.3 nTPM
Placenta	13.0 nTPM

Intestinal goblet cells	16.4 nTPM
Colon	19.3 nTPM
Rectum	16.0 nTPM
Small intestine	14.0 nTPM

Macrophages	25.2 nTPM
Adipose tissue	45.1 nTPM
Bone marrow	41.2 nTPM
Endometrium	37.9 nTPM
Stomach	32.2 nTPM
Lung	31.1 nTPM
Spleen	30.0 nTPM
Prostate	27.5 nTPM
Breast	25.9 nTPM
Ovary	23.5 nTPM
Testis	23.2 nTPM
Skeletal muscle	22.8 nTPM
Kidney	15.8 nTPM
Esophagus	11.0 nTPM
Pancreas	10.2 nTPM
PBMC	0.0 nTPM

Paneth cells	19.0 nTPM
Colon	26.4 nTPM
Rectum	19.3 nTPM
Small intestine	11.3 nTPM

Plasma cells	26.5 nTPM
Adipose tissue	49.1 nTPM
Stomach	40.8 nTPM
Spleen	18.9 nTPM
Esophagus	12.3 nTPM
Bone marrow	11.5 nTPM

Respiratory ciliated cells	12.4 nTPM
Bronchus	14.7 nTPM
Lung	10.2 nTPM

Smooth muscle cells	24.2 nTPM
Heart muscle	60.6 nTPM
Adipose tissue	33.5 nTPM
Endometrium	29.1 nTPM
Prostate	23.7 nTPM
Esophagus	23.3 nTPM
Breast	21.6 nTPM
Ovary	21.3 nTPM
Skeletal muscle	18.8 nTPM
Bronchus	12.3 nTPM
Pancreas	11.6 nTPM
Skin	10.4 nTPM

T-cells	29.0 nTPM
Adipose tissue	52.6 nTPM
Endometrium	43.4 nTPM
Stomach	41.8 nTPM
Bone marrow	40.1 nTPM
Lung	39.5 nTPM
Breast	35.1 nTPM
Spleen	34.2 nTPM
Colon	30.4 nTPM
Ovary	26.7 nTPM
Lymph node	24.0 nTPM
Skin	22.1 nTPM
PBMC	21.7 nTPM
Liver	20.7 nTPM
Skeletal muscle	18.5 nTPM
Kidney	14.4 nTPM
Prostate	14.2 nTPM
Esophagus	13.1 nTPM

Basal keratinocytes	15.0 nTPM
Skin	15.0 nTPM

Basal prostatic cells	28.8 nTPM
Prostate	28.8 nTPM

Basal respiratory cells	17.9 nTPM
Bronchus	17.9 nTPM

Cone photoreceptor cells	33.3 nTPM
Eye	33.3 nTPM

Undifferentiated cells	17.1 nTPM
Colon	18.7 nTPM
Rectum	17.6 nTPM
Small intestine	15.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC