Single cell type - MED17 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MED17
Gene descriptionⁱ Full gene name according to HGNC.	Mediator complex subunit 17
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MED17 is part of cluster 52 Non-specific - Transcription with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
NUP160	Nucleoporin 160	0.6492	52
FNBP4	Formin binding protein 4	0.5892	52
DCP1A	Decapping mRNA 1A	0.5850	22
UBA6	Ubiquitin like modifier activating enzyme 6	0.5399	22
RBM14	RNA binding motif protein 14	0.5208	39
SCAF4	SR-related CTD associated factor 4	0.5081	59
ZNF121	Zinc finger protein 121	0.5057	22
CCDC12	Coiled-coil domain containing 12	0.4946	39
SF1	Splicing factor 1	0.4916	57
TAF1D	TATA-box binding protein associated factor, RNA polymerase I subunit D	0.4901	52
EBLN2	Endogenous Bornavirus like nucleoprotein 2	0.4894	52
NGDN	Neuroguidin	0.4874	39
HNRNPA0	Heterogeneous nuclear ribonucleoprotein A0	0.4839	48
CHD2	Chromodomain helicase DNA binding protein 2	0.4789	44
PGAP1	Post-GPI attachment to proteins inositol deacylase 1	0.4711	8

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	7.7 nTPM
Adipose tissue	11.2 nTPM
Breast	4.3 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	9.3 nTPM
Lung	9.3 nTPM

Astrocytes	16.3 nTPM
Brain	16.3 nTPM

B-cells	32.1 nTPM
Stomach	47.7 nTPM
Colon	46.4 nTPM
PBMC	38.6 nTPM
Lymph node	35.7 nTPM
Adipose tissue	34.1 nTPM
Spleen	33.6 nTPM
Kidney	28.5 nTPM
Liver	26.7 nTPM
Bone marrow	24.5 nTPM
Breast	5.3 nTPM

Dendritic cells	25.5 nTPM
Adipose tissue	35.0 nTPM
PBMC	23.9 nTPM
Breast	17.5 nTPM

Endothelial cells	14.2 nTPM
Prostate	30.1 nTPM
Skin	19.2 nTPM
Skeletal muscle	17.7 nTPM
Esophagus	17.5 nTPM
Endometrium	16.4 nTPM
Heart muscle	14.9 nTPM
Testis	14.5 nTPM
Placenta	12.5 nTPM
Eye	12.2 nTPM
Liver	11.9 nTPM
Pancreas	11.6 nTPM
Ovary	8.9 nTPM
Lung	6.2 nTPM
Breast	5.2 nTPM

Fibroblasts	17.2 nTPM
Prostate	35.0 nTPM
Lung	22.4 nTPM
Skin	19.5 nTPM
Skeletal muscle	19.3 nTPM
Heart muscle	18.2 nTPM
Stomach	17.8 nTPM
Placenta	17.1 nTPM
Esophagus	13.2 nTPM
Ovary	11.9 nTPM
Adipose tissue	8.7 nTPM
Breast	6.0 nTPM

Intestinal goblet cells	13.4 nTPM
Colon	17.2 nTPM
Rectum	11.9 nTPM
Small intestine	11.1 nTPM

Macrophages	12.8 nTPM
Prostate	29.8 nTPM
Skeletal muscle	22.4 nTPM
Adipose tissue	21.6 nTPM
Stomach	20.5 nTPM
Testis	19.2 nTPM
Spleen	14.5 nTPM
Endometrium	13.0 nTPM
Esophagus	11.0 nTPM
Bone marrow	10.0 nTPM
Breast	7.5 nTPM
Ovary	7.1 nTPM
Kidney	6.8 nTPM
Lung	6.8 nTPM
Pancreas	2.5 nTPM
PBMC	0.0 nTPM

Paneth cells	14.8 nTPM
Small intestine	18.8 nTPM
Rectum	15.5 nTPM
Colon	9.9 nTPM

Plasma cells	25.6 nTPM
Adipose tissue	45.8 nTPM
Stomach	25.4 nTPM
Bone marrow	19.8 nTPM
Spleen	18.5 nTPM
Esophagus	18.4 nTPM

Respiratory ciliated cells	19.4 nTPM
Lung	20.4 nTPM
Bronchus	18.3 nTPM

Smooth muscle cells	16.4 nTPM
Prostate	29.7 nTPM
Skin	22.0 nTPM
Heart muscle	20.5 nTPM
Esophagus	18.6 nTPM
Endometrium	18.5 nTPM
Skeletal muscle	16.9 nTPM
Ovary	14.6 nTPM
Pancreas	14.0 nTPM
Adipose tissue	12.5 nTPM
Bronchus	8.4 nTPM
Breast	4.1 nTPM

T-cells	28.1 nTPM
Colon	58.5 nTPM
Adipose tissue	41.3 nTPM
Esophagus	39.3 nTPM
Lymph node	32.0 nTPM
Skeletal muscle	31.6 nTPM
Skin	31.3 nTPM
Stomach	31.2 nTPM
PBMC	31.1 nTPM
Liver	30.2 nTPM
Spleen	27.8 nTPM
Endometrium	25.1 nTPM
Bone marrow	22.3 nTPM
Breast	19.3 nTPM
Kidney	16.4 nTPM
Lung	15.2 nTPM
Prostate	14.2 nTPM
Ovary	11.1 nTPM

Basal prostatic cells	39.6 nTPM
Prostate	39.6 nTPM

Cholangiocytes	14.3 nTPM
Liver	14.3 nTPM

Collecting duct cells	7.3 nTPM
Kidney	7.3 nTPM

Cone photoreceptor cells	16.7 nTPM
Eye	16.7 nTPM

Undifferentiated cells	17.6 nTPM
Colon	23.2 nTPM
Small intestine	15.1 nTPM
Rectum	14.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC