Single cell type - HEXB - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HEXB
Gene descriptionⁱ Full gene name according to HGNC.	Hexosaminidase subunit beta
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Metabolic proteins Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Cytotrophoblasts - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Syncytiotrophoblasts, Cytotrophoblasts, Hofbauer cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (ASC diff, GAMG)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Syncytiotrophoblasts, Cytotrophoblasts, Hofbauer cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

HEXB is part of cluster 47 Cytotrophoblasts - Unknown function with confidenceⁱ 1
226 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CTSL	Cathepsin L	0.7680	4
COMT	Catechol-O-methyltransferase	0.7371	47
LRPAP1	LDL receptor related protein associated protein 1	0.7120	47
GSDME	Gasdermin E	0.6818	47
IFI6	Interferon alpha inducible protein 6	0.6732	47
CLN3	CLN3 lysosomal/endosomal transmembrane protein, battenin	0.6655	47
HEXA	Hexosaminidase subunit alpha	0.6639	4
SLC39A1	Solute carrier family 39 member 1	0.6611	47
TRBV20OR9-2	T cell receptor beta variable 20/OR9-2 (non-functional)	0.6603	47
SLC29A3	Solute carrier family 29 member 3	0.6565	47
SMIM43	Small integral membrane protein 43	0.6563	47
SCAMP2	Secretory carrier membrane protein 2	0.6545	10
PAGE4	PAGE family member 4	0.6509	47
EFEMP1	EGF containing fibulin extracellular matrix protein 1	0.6450	47
SOX14	SRY-box transcription factor 14	0.6446	47

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	49.6 nTPM
Adipose tissue	54.3 nTPM
Breast	44.9 nTPM

Alveolar cells type 1	41.7 nTPM
Lung	41.7 nTPM

Alveolar cells type 2	38.4 nTPM
Lung	38.4 nTPM

Astrocytes	5.9 nTPM
Brain	5.9 nTPM

B-cells	31.5 nTPM
Liver	66.1 nTPM
Kidney	47.6 nTPM
Colon	36.7 nTPM
Breast	34.7 nTPM
Stomach	27.3 nTPM
Spleen	26.7 nTPM
PBMC	25.7 nTPM
Lymph node	18.3 nTPM
Bone marrow	17.2 nTPM
Adipose tissue	14.6 nTPM

Dendritic cells	32.8 nTPM
PBMC	43.8 nTPM
Breast	27.7 nTPM
Adipose tissue	26.8 nTPM

Endothelial cells	56.2 nTPM
Placenta	95.5 nTPM
Liver	77.1 nTPM
Eye	74.4 nTPM
Prostate	70.1 nTPM
Pancreas	69.5 nTPM
Skin	68.8 nTPM
Breast	48.8 nTPM
Ovary	48.2 nTPM
Skeletal muscle	47.7 nTPM
Esophagus	44.8 nTPM
Testis	43.8 nTPM
Endometrium	36.8 nTPM
Lung	31.2 nTPM
Heart muscle	30.3 nTPM

Fibroblasts	107.2 nTPM
Esophagus	183.4 nTPM
Stomach	154.4 nTPM
Skin	151.3 nTPM
Prostate	146.7 nTPM
Adipose tissue	131.7 nTPM
Placenta	112.4 nTPM
Skeletal muscle	106.9 nTPM
Breast	89.7 nTPM
Ovary	41.0 nTPM
Heart muscle	38.8 nTPM
Lung	23.4 nTPM

Intestinal goblet cells	56.7 nTPM
Colon	57.2 nTPM
Small intestine	56.8 nTPM
Rectum	56.2 nTPM

Macrophages	168.8 nTPM
Pancreas	622.8 nTPM
Prostate	231.5 nTPM
Ovary	222.7 nTPM
Lung	219.6 nTPM
Testis	186.5 nTPM
Stomach	164.1 nTPM
Kidney	145.2 nTPM
Esophagus	132.2 nTPM
Adipose tissue	128.2 nTPM
Bone marrow	97.4 nTPM
Spleen	94.3 nTPM
Skeletal muscle	88.0 nTPM
Breast	75.7 nTPM
Endometrium	69.0 nTPM
PBMC	54.6 nTPM

Paneth cells	54.8 nTPM
Rectum	71.5 nTPM
Colon	59.3 nTPM
Small intestine	33.8 nTPM

Plasma cells	71.5 nTPM
Stomach	92.0 nTPM
Esophagus	86.2 nTPM
Spleen	79.3 nTPM
Bone marrow	64.2 nTPM
Adipose tissue	35.5 nTPM

Respiratory ciliated cells	36.3 nTPM
Bronchus	50.8 nTPM
Lung	21.9 nTPM

Smooth muscle cells	49.5 nTPM
Pancreas	121.9 nTPM
Bronchus	83.1 nTPM
Prostate	61.2 nTPM
Adipose tissue	47.3 nTPM
Skin	45.0 nTPM
Skeletal muscle	40.6 nTPM
Esophagus	37.2 nTPM
Breast	33.5 nTPM
Heart muscle	29.5 nTPM
Ovary	26.2 nTPM
Endometrium	18.7 nTPM

T-cells	35.3 nTPM
Prostate	66.3 nTPM
Skin	49.2 nTPM
Kidney	48.6 nTPM
Ovary	46.7 nTPM
Lung	41.0 nTPM
Colon	39.9 nTPM
Spleen	38.1 nTPM
Bone marrow	35.8 nTPM
Liver	35.2 nTPM
PBMC	32.5 nTPM
Stomach	30.9 nTPM
Adipose tissue	26.9 nTPM
Breast	25.6 nTPM
Skeletal muscle	25.2 nTPM
Lymph node	24.6 nTPM
Esophagus	19.7 nTPM
Endometrium	14.0 nTPM

Basal keratinocytes	44.0 nTPM
Skin	44.0 nTPM

Basal prostatic cells	82.8 nTPM
Prostate	82.8 nTPM

Basal respiratory cells	103.2 nTPM
Bronchus	103.2 nTPM

Basal squamous epithelial cells	21.6 nTPM
Esophagus	21.6 nTPM

Undifferentiated cells	81.8 nTPM
Rectum	85.6 nTPM
Small intestine	82.2 nTPM
Colon	77.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC