Single cell type - PIK3CB - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PIK3CB
Gene descriptionⁱ Full gene name according to HGNC.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Enzymes Metabolic proteins Plasma proteins RAS pathway related proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Extravillous trophoblasts - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Excitatory neurons, Inhibitory neurons, Oligodendrocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HEL, HMC-1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Excitatory neurons, Inhibitory neurons, Oligodendrocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PIK3CB is part of cluster 38 Extravillous trophoblasts - Unknown function with confidenceⁱ 1
176 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ARFGEF2	ADP ribosylation factor guanine nucleotide exchange factor 2	0.5279	21
PCTP	Phosphatidylcholine transfer protein	0.4985	67
RAB15	RAB15, member RAS oncogene family	0.4977	21
SYNJ1	Synaptojanin 1	0.4728	21
ANKRD24	Ankyrin repeat domain 24	0.4712	21
CMIP	C-Maf inducing protein	0.4672	51
UBQLN1	Ubiquilin 1	0.4645	10
XAGE2	X antigen family member 2	0.4604	38
FAM89A	Family with sequence similarity 89 member A	0.4587	38
MAPK9	Mitogen-activated protein kinase 9	0.4581	8
EZHIP	EZH inhibitory protein	0.4547	38
SLC25A16	Solute carrier family 25 member 16	0.4544	8
PRKAG2	Protein kinase AMP-activated non-catalytic subunit gamma 2	0.4451	21
UBAC2	UBA domain containing 2	0.4433	51
ARHGAP26	Rho GTPase activating protein 26	0.4413	21

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	19.7 nTPM
Adipose tissue	23.2 nTPM
Breast	16.1 nTPM

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	21.3 nTPM
Lung	21.3 nTPM

Astrocytes	40.1 nTPM
Brain	40.1 nTPM

B-cells	12.1 nTPM
Bone marrow	19.6 nTPM
Colon	19.2 nTPM
Stomach	17.2 nTPM
Lymph node	13.4 nTPM
PBMC	11.5 nTPM
Spleen	11.4 nTPM
Adipose tissue	9.6 nTPM
Breast	9.4 nTPM
Liver	5.0 nTPM
Kidney	4.8 nTPM

Dendritic cells	6.9 nTPM
PBMC	8.0 nTPM
Adipose tissue	6.6 nTPM
Breast	6.2 nTPM

Endothelial cells	13.9 nTPM
Heart muscle	46.1 nTPM
Skeletal muscle	22.8 nTPM
Esophagus	14.8 nTPM
Ovary	14.6 nTPM
Breast	13.8 nTPM
Prostate	13.5 nTPM
Lung	12.5 nTPM
Skin	10.3 nTPM
Endometrium	9.7 nTPM
Testis	9.2 nTPM
Eye	8.1 nTPM
Pancreas	7.7 nTPM
Liver	6.4 nTPM
Placenta	5.1 nTPM

Fibroblasts	7.3 nTPM
Lung	14.5 nTPM
Heart muscle	10.2 nTPM
Esophagus	8.4 nTPM
Skeletal muscle	7.5 nTPM
Prostate	7.4 nTPM
Skin	7.2 nTPM
Stomach	6.0 nTPM
Breast	6.0 nTPM
Ovary	4.7 nTPM
Placenta	4.6 nTPM
Adipose tissue	4.3 nTPM

Intestinal goblet cells	17.1 nTPM
Small intestine	18.4 nTPM
Colon	16.5 nTPM
Rectum	16.4 nTPM

Macrophages	28.1 nTPM
PBMC	68.2 nTPM
Prostate	40.1 nTPM
Adipose tissue	32.4 nTPM
Bone marrow	31.2 nTPM
Spleen	30.0 nTPM
Lung	29.3 nTPM
Kidney	28.7 nTPM
Skeletal muscle	28.4 nTPM
Endometrium	27.0 nTPM
Stomach	26.4 nTPM
Ovary	21.1 nTPM
Testis	19.2 nTPM
Breast	18.2 nTPM
Esophagus	11.0 nTPM
Pancreas	10.2 nTPM

Paneth cells	25.9 nTPM
Small intestine	33.8 nTPM
Rectum	24.1 nTPM
Colon	19.7 nTPM

Plasma cells	10.2 nTPM
Adipose tissue	13.6 nTPM
Bone marrow	13.2 nTPM
Stomach	12.3 nTPM
Spleen	12.0 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	17.4 nTPM
Bronchus	18.8 nTPM
Lung	16.0 nTPM

Smooth muscle cells	5.9 nTPM
Heart muscle	9.1 nTPM
Skin	7.0 nTPM
Prostate	6.9 nTPM
Breast	6.7 nTPM
Endometrium	6.4 nTPM
Adipose tissue	6.2 nTPM
Esophagus	6.2 nTPM
Ovary	4.6 nTPM
Skeletal muscle	4.1 nTPM
Bronchus	3.8 nTPM
Pancreas	3.6 nTPM

T-cells	11.6 nTPM
Lymph node	21.0 nTPM
Bone marrow	16.8 nTPM
Breast	16.6 nTPM
Endometrium	15.2 nTPM
Spleen	15.0 nTPM
Adipose tissue	14.3 nTPM
Skeletal muscle	12.2 nTPM
Kidney	11.6 nTPM
PBMC	11.3 nTPM
Ovary	11.1 nTPM
Stomach	10.3 nTPM
Prostate	9.5 nTPM
Lung	9.1 nTPM
Colon	6.6 nTPM
Esophagus	6.6 nTPM
Liver	5.2 nTPM
Skin	5.0 nTPM

Basal keratinocytes	19.1 nTPM
Skin	19.1 nTPM

Basal prostatic cells	18.7 nTPM
Prostate	18.7 nTPM

Basal squamous epithelial cells	14.2 nTPM
Esophagus	14.2 nTPM

Cholangiocytes	12.8 nTPM
Liver	12.8 nTPM

Undifferentiated cells	15.1 nTPM
Rectum	18.0 nTPM
Small intestine	15.2 nTPM
Colon	12.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC