Single cell type - RELT - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RELT
Gene descriptionⁱ Full gene name according to HGNC.	RELT TNF receptor
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Macrophages - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Macrophages, Langerhans cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Macrophages, Langerhans cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

RELT is part of cluster 41 Macrophages - Immune response with confidenceⁱ 1
307 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TREML4	Triggering receptor expressed on myeloid cells like 4	0.6416	41
BCL2A1	BCL2 related protein A1	0.6340	41
CASP9	Caspase 9	0.6011	41
SERPINB9	Serpin family B member 9	0.5958	41
PTPN1	Protein tyrosine phosphatase non-receptor type 1	0.5951	65
RILPL2	Rab interacting lysosomal protein like 2	0.5912	41
G0S2	G0/G1 switch 2	0.5850	41
THBS1	Thrombospondin 1	0.5848	41
IL1B	Interleukin 1 beta	0.5846	41
THEMIS2	Thymocyte selection associated family member 2	0.5843	65
REL	REL proto-oncogene, NF-kB subunit	0.5821	41
STX11	Syntaxin 11	0.5756	41
NINJ1	Ninjurin 1	0.5748	41
AREG	Amphiregulin	0.5744	41
KDM6B	Lysine demethylase 6B	0.5716	41

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	5.7 nTPM
Adipose tissue	7.5 nTPM
Breast	3.9 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	2.2 nTPM
Lung	2.2 nTPM

Astrocytes	3.6 nTPM
Brain	3.6 nTPM

B-cells	24.2 nTPM
Colon	46.4 nTPM
Adipose tissue	37.5 nTPM
Bone marrow	29.4 nTPM
Breast	26.8 nTPM
Spleen	23.9 nTPM
Stomach	22.7 nTPM
Kidney	19.0 nTPM
Lymph node	16.3 nTPM
PBMC	9.9 nTPM
Liver	9.7 nTPM

Dendritic cells	33.0 nTPM
PBMC	47.8 nTPM
Adipose tissue	30.7 nTPM
Breast	20.4 nTPM

Endothelial cells	7.2 nTPM
Prostate	31.4 nTPM
Pancreas	15.5 nTPM
Skin	12.8 nTPM
Ovary	11.7 nTPM
Endometrium	9.2 nTPM
Skeletal muscle	4.2 nTPM
Breast	3.5 nTPM
Lung	3.1 nTPM
Eye	2.4 nTPM
Esophagus	2.1 nTPM
Testis	1.8 nTPM
Placenta	1.7 nTPM
Heart muscle	0.9 nTPM
Liver	0.0 nTPM

Fibroblasts	10.1 nTPM
Prostate	66.3 nTPM
Lung	13.4 nTPM
Skin	10.3 nTPM
Stomach	4.4 nTPM
Skeletal muscle	4.1 nTPM
Placenta	3.9 nTPM
Ovary	3.0 nTPM
Breast	1.9 nTPM
Adipose tissue	1.6 nTPM
Heart muscle	1.3 nTPM
Esophagus	0.4 nTPM

Intestinal goblet cells	2.8 nTPM
Colon	7.2 nTPM
Rectum	0.8 nTPM
Small intestine	0.4 nTPM

Macrophages	43.9 nTPM
Prostate	80.2 nTPM
Adipose tissue	72.8 nTPM
Bone marrow	61.2 nTPM
Endometrium	60.1 nTPM
Skeletal muscle	53.3 nTPM
Kidney	48.5 nTPM
Breast	48.0 nTPM
Pancreas	46.0 nTPM
Spleen	41.4 nTPM
Stomach	38.1 nTPM
Esophagus	29.9 nTPM
Ovary	29.1 nTPM
Lung	26.7 nTPM
Testis	22.6 nTPM
PBMC	0.0 nTPM

Paneth cells	2.4 nTPM
Colon	6.5 nTPM
Rectum	0.6 nTPM
Small intestine	0.0 nTPM

Plasma cells	19.2 nTPM
Adipose tissue	30.3 nTPM
Stomach	26.4 nTPM
Spleen	16.9 nTPM
Esophagus	12.3 nTPM
Bone marrow	9.9 nTPM

Respiratory ciliated cells	1.4 nTPM
Lung	1.5 nTPM
Bronchus	1.4 nTPM

Smooth muscle cells	14.5 nTPM
Prostate	63.8 nTPM
Skin	44.4 nTPM
Adipose tissue	9.7 nTPM
Pancreas	9.1 nTPM
Ovary	7.7 nTPM
Endometrium	7.5 nTPM
Breast	6.5 nTPM
Skeletal muscle	5.7 nTPM
Heart muscle	3.3 nTPM
Esophagus	1.5 nTPM
Bronchus	0.0 nTPM

T-cells	16.1 nTPM
Prostate	37.9 nTPM
Colon	34.2 nTPM
Adipose tissue	30.7 nTPM
Endometrium	27.4 nTPM
Breast	22.1 nTPM
Esophagus	19.7 nTPM
Skin	19.3 nTPM
Stomach	15.3 nTPM
Skeletal muscle	13.7 nTPM
Spleen	9.9 nTPM
Ovary	8.9 nTPM
Liver	8.6 nTPM
Bone marrow	7.5 nTPM
Lung	6.1 nTPM
PBMC	5.6 nTPM
Lymph node	4.0 nTPM
Kidney	2.7 nTPM

Basal keratinocytes	26.5 nTPM
Skin	26.5 nTPM

Basal prostatic cells	15.4 nTPM
Prostate	15.4 nTPM

Cone photoreceptor cells	12.5 nTPM
Eye	12.5 nTPM

Endometrial stromal cells	5.2 nTPM
Endometrium	5.2 nTPM

Undifferentiated cells	3.1 nTPM
Colon	6.8 nTPM
Small intestine	1.5 nTPM
Rectum	0.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC