Single cell type - CDK17 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CDK17
Gene descriptionⁱ Full gene name according to HGNC.	Cyclin dependent kinase 17
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Oligodendrocytes, Excitatory neurons)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HUVEC TERT2, TIME)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Oligodendrocytes, Excitatory neurons)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CDK17 is part of cluster 59 Non-specific - Transcription with confidenceⁱ 1
354 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PPP1R16B	Protein phosphatase 1 regulatory subunit 16B	0.7134	59
ZGPAT	Zinc finger CCCH-type and G-patch domain containing	0.6055	59
IL12RB2	Interleukin 12 receptor subunit beta 2	0.6022	58
ZNF410	Zinc finger protein 410	0.5827	59
NUP133	Nucleoporin 133	0.5805	59
SLC25A32	Solute carrier family 25 member 32	0.5763	59
GAL3ST2	Galactose-3-O-sulfotransferase 2	0.5723	58
HMGN4	High mobility group nucleosomal binding domain 4	0.5722	59
ATP8A1	ATPase phospholipid transporting 8A1	0.5700	42
MAPRE2	Microtubule associated protein RP/EB family member 2	0.5681	42
MBNL1	Muscleblind like splicing regulator 1	0.5647	59
ARHGEF18	Rho/Rac guanine nucleotide exchange factor 18	0.5581	21
IFITM1	Interferon induced transmembrane protein 1	0.5573	58
TRGV10	T cell receptor gamma variable 10 (non-functional)	0.5569	58
CBLB	Cbl proto-oncogene B	0.5472	24

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	58.1 nTPM
Adipose tissue	78.6 nTPM
Breast	37.7 nTPM

Alveolar cells type 1	16.0 nTPM
Lung	16.0 nTPM

Alveolar cells type 2	6.5 nTPM
Lung	6.5 nTPM

Astrocytes	54.5 nTPM
Brain	54.5 nTPM

B-cells	37.3 nTPM
Stomach	91.3 nTPM
Lymph node	69.7 nTPM
Spleen	66.1 nTPM
Adipose tissue	40.7 nTPM
Bone marrow	33.5 nTPM
Colon	22.3 nTPM
Liver	21.5 nTPM
Breast	14.7 nTPM
PBMC	12.9 nTPM
Kidney	0.0 nTPM

Dendritic cells	64.4 nTPM
Adipose tissue	121.5 nTPM
Breast	63.8 nTPM
PBMC	8.0 nTPM

Endothelial cells	51.7 nTPM
Esophagus	92.3 nTPM
Lung	74.8 nTPM
Prostate	69.1 nTPM
Skeletal muscle	61.3 nTPM
Skin	58.8 nTPM
Pancreas	57.9 nTPM
Heart muscle	56.1 nTPM
Ovary	52.7 nTPM
Endometrium	50.4 nTPM
Testis	41.5 nTPM
Placenta	34.7 nTPM
Breast	34.6 nTPM
Liver	25.7 nTPM
Eye	13.7 nTPM

Fibroblasts	24.0 nTPM
Stomach	87.6 nTPM
Skin	30.0 nTPM
Prostate	22.5 nTPM
Lung	21.2 nTPM
Skeletal muscle	21.2 nTPM
Esophagus	19.5 nTPM
Adipose tissue	18.6 nTPM
Heart muscle	16.4 nTPM
Breast	12.3 nTPM
Ovary	8.5 nTPM
Placenta	6.2 nTPM

Intestinal goblet cells	7.9 nTPM
Rectum	10.5 nTPM
Colon	7.8 nTPM
Small intestine	5.5 nTPM

Macrophages	16.7 nTPM
Adipose tissue	34.6 nTPM
Stomach	26.4 nTPM
Spleen	24.9 nTPM
Esophagus	22.0 nTPM
Bone marrow	17.5 nTPM
Endometrium	15.3 nTPM
Ovary	15.3 nTPM
Skeletal muscle	14.9 nTPM
PBMC	13.6 nTPM
Breast	13.4 nTPM
Lung	13.2 nTPM
Kidney	10.6 nTPM
Pancreas	10.2 nTPM
Testis	9.8 nTPM
Prostate	8.1 nTPM

Paneth cells	3.4 nTPM
Rectum	6.5 nTPM
Small intestine	3.7 nTPM
Colon	0.0 nTPM

Plasma cells	64.7 nTPM
Adipose tissue	118.7 nTPM
Spleen	64.3 nTPM
Bone marrow	59.4 nTPM
Stomach	56.7 nTPM
Esophagus	24.6 nTPM

Respiratory ciliated cells	15.4 nTPM
Bronchus	20.6 nTPM
Lung	10.2 nTPM

Smooth muscle cells	22.0 nTPM
Esophagus	43.4 nTPM
Skin	38.7 nTPM
Prostate	34.0 nTPM
Heart muscle	23.0 nTPM
Adipose tissue	19.1 nTPM
Endometrium	18.5 nTPM
Bronchus	17.9 nTPM
Skeletal muscle	15.5 nTPM
Pancreas	10.7 nTPM
Ovary	10.7 nTPM
Breast	9.9 nTPM

T-cells	63.2 nTPM
Stomach	157.2 nTPM
Spleen	149.3 nTPM
Adipose tissue	124.3 nTPM
Lymph node	119.2 nTPM
Endometrium	72.1 nTPM
Bone marrow	62.2 nTPM
Colon	59.9 nTPM
Skin	58.0 nTPM
Skeletal muscle	51.7 nTPM
Breast	47.0 nTPM
Esophagus	45.9 nTPM
Liver	33.7 nTPM
Ovary	26.7 nTPM
Prostate	19.0 nTPM
Kidney	17.8 nTPM
Lung	16.7 nTPM
PBMC	13.5 nTPM

Basal keratinocytes	26.8 nTPM
Skin	26.8 nTPM

Basal respiratory cells	8.6 nTPM
Bronchus	8.6 nTPM

Basal squamous epithelial cells	19.4 nTPM
Esophagus	19.4 nTPM

Cholangiocytes	7.2 nTPM
Liver	7.2 nTPM

Undifferentiated cells	6.0 nTPM
Rectum	7.8 nTPM
Small intestine	5.5 nTPM
Colon	4.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC