Single cell type - PDIA5 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PDIA5
Gene descriptionⁱ Full gene name according to HGNC.	Protein disulfide isomerase family A member 5
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Extravillous trophoblasts - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Extravillous trophoblasts)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (plasmacytoid DC)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Extravillous trophoblasts)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PDIA5 is part of cluster 38 Extravillous trophoblasts - Unknown function with confidenceⁱ 1
176 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CNPY2	Canopy FGF signaling regulator 2	0.6623	38
QSOX1	Quiescin sulfhydryl oxidase 1	0.6603	38
C1QTNF6	C1q and TNF related 6	0.6405	38
HLA-G	Major histocompatibility complex, class I, G	0.6392	38
B4GALT7	Beta-1,4-galactosyltransferase 7	0.6374	38
AC004556.3	39S ribosomal protein L23, mitochondrial	0.6372	38
FN1	Fibronectin 1	0.6347	38
KRT33B	Keratin 33B	0.6296	38
ITGA5	Integrin subunit alpha 5	0.6294	38
FSTL3	Follistatin like 3	0.6291	38
ADAM12	ADAM metallopeptidase domain 12	0.6283	38
TFPI	Tissue factor pathway inhibitor	0.6269	38
OXGR1	Oxoglutarate receptor 1	0.6257	38
PRG2	Proteoglycan 2, pro eosinophil major basic protein	0.6256	38
GPR78	G protein-coupled receptor 78	0.6237	38

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	17.2 nTPM
Adipose tissue	24.2 nTPM
Breast	10.2 nTPM

Alveolar cells type 1	19.2 nTPM
Lung	19.2 nTPM

Alveolar cells type 2	30.7 nTPM
Lung	30.7 nTPM

Astrocytes	2.6 nTPM
Brain	2.6 nTPM

B-cells	5.6 nTPM
Liver	28.8 nTPM
Breast	10.7 nTPM
Bone marrow	4.1 nTPM
Colon	3.2 nTPM
Spleen	2.8 nTPM
Stomach	2.2 nTPM
Lymph node	1.6 nTPM
PBMC	1.4 nTPM
Adipose tissue	1.0 nTPM
Kidney	0.0 nTPM

Dendritic cells	3.1 nTPM
PBMC	8.0 nTPM
Adipose tissue	0.9 nTPM
Breast	0.4 nTPM

Endothelial cells	24.3 nTPM
Skin	43.3 nTPM
Lung	37.4 nTPM
Heart muscle	36.4 nTPM
Esophagus	34.5 nTPM
Pancreas	30.9 nTPM
Skeletal muscle	29.1 nTPM
Breast	29.1 nTPM
Placenta	25.6 nTPM
Liver	22.9 nTPM
Prostate	18.4 nTPM
Endometrium	11.8 nTPM
Ovary	8.5 nTPM
Testis	7.4 nTPM
Eye	4.8 nTPM

Fibroblasts	20.7 nTPM
Placenta	51.3 nTPM
Stomach	31.2 nTPM
Lung	25.7 nTPM
Ovary	23.5 nTPM
Skin	18.6 nTPM
Esophagus	15.7 nTPM
Prostate	15.4 nTPM
Breast	14.1 nTPM
Adipose tissue	12.6 nTPM
Skeletal muscle	11.6 nTPM
Heart muscle	7.9 nTPM

Intestinal goblet cells	36.9 nTPM
Colon	52.1 nTPM
Rectum	41.2 nTPM
Small intestine	17.3 nTPM

Macrophages	4.4 nTPM
PBMC	13.6 nTPM
Lung	8.6 nTPM
Endometrium	6.2 nTPM
Skeletal muscle	5.3 nTPM
Pancreas	5.1 nTPM
Ovary	4.6 nTPM
Breast	4.1 nTPM
Bone marrow	3.7 nTPM
Testis	3.5 nTPM
Adipose tissue	3.1 nTPM
Spleen	3.1 nTPM
Prostate	2.2 nTPM
Esophagus	1.6 nTPM
Kidney	1.5 nTPM
Stomach	0.0 nTPM

Paneth cells	7.6 nTPM
Rectum	19.0 nTPM
Small intestine	3.7 nTPM
Colon	0.0 nTPM

Plasma cells	40.1 nTPM
Stomach	67.3 nTPM
Spleen	51.0 nTPM
Bone marrow	41.2 nTPM
Esophagus	30.7 nTPM
Adipose tissue	10.3 nTPM

Respiratory ciliated cells	6.4 nTPM
Lung	8.7 nTPM
Bronchus	4.0 nTPM

Smooth muscle cells	17.6 nTPM
Heart muscle	43.5 nTPM
Pancreas	40.0 nTPM
Bronchus	30.2 nTPM
Endometrium	16.2 nTPM
Ovary	16.0 nTPM
Breast	10.7 nTPM
Esophagus	9.3 nTPM
Prostate	8.2 nTPM
Skin	7.3 nTPM
Adipose tissue	6.4 nTPM
Skeletal muscle	5.5 nTPM

T-cells	3.1 nTPM
Prostate	14.2 nTPM
Lung	7.6 nTPM
Skin	4.6 nTPM
Ovary	4.5 nTPM
Endometrium	4.4 nTPM
Liver	2.9 nTPM
Lymph node	2.1 nTPM
Kidney	2.0 nTPM
Spleen	2.0 nTPM
Breast	1.8 nTPM
PBMC	1.5 nTPM
Skeletal muscle	1.5 nTPM
Colon	1.4 nTPM
Bone marrow	1.0 nTPM
Adipose tissue	0.9 nTPM
Stomach	0.6 nTPM
Esophagus	0.0 nTPM

Basal keratinocytes	5.0 nTPM
Skin	5.0 nTPM

Basal prostatic cells	6.0 nTPM
Prostate	6.0 nTPM

Basal squamous epithelial cells	3.4 nTPM
Esophagus	3.4 nTPM

Cholangiocytes	35.8 nTPM
Liver	35.8 nTPM

Undifferentiated cells	15.1 nTPM
Rectum	21.0 nTPM
Colon	12.5 nTPM
Small intestine	11.8 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC