Single cell type - ELOVL1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ELOVL1
Gene descriptionⁱ Full gene name according to HGNC.	ELOVL fatty acid elongase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Mammary glandular cells - Lactation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ELOVL1 is part of cluster 30 Mammary glandular cells - Lactation with confidenceⁱ 1
85 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SERINC2	Serine incorporator 2	0.6337	53
PLIN3	Perilipin 3	0.6275	53
UGP2	UDP-glucose pyrophosphorylase 2	0.6092	30
XDH	Xanthine dehydrogenase	0.6027	30
GIPC1	GIPC PDZ domain containing family member 1	0.5934	53
CCL28	C-C motif chemokine ligand 28	0.5521	30
LYPLA2	Lysophospholipase 2	0.5479	53
GTF3C5	General transcription factor IIIC subunit 5	0.5383	52
ODAM	Odontogenic, ameloblast associated	0.5347	30
CORO1B	Coronin 1B	0.5282	53
CEL	Carboxyl ester lipase	0.5145	30
C6orf15	Chromosome 6 open reading frame 15	0.5120	30
CD24	CD24 molecule	0.5096	30
JOSD2	Josephin domain containing 2	0.5057	53
KLK6	Kallikrein related peptidase 6	0.5047	30

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	44.0 nTPM
Breast	50.6 nTPM
Adipose tissue	37.4 nTPM

Alveolar cells type 1	19.2 nTPM
Lung	19.2 nTPM

Alveolar cells type 2	12.5 nTPM
Lung	12.5 nTPM

Astrocytes	7.5 nTPM
Brain	7.5 nTPM

B-cells	28.1 nTPM
Spleen	37.7 nTPM
Stomach	37.3 nTPM
Adipose tissue	32.1 nTPM
Colon	30.3 nTPM
Breast	28.1 nTPM
Bone marrow	27.8 nTPM
PBMC	27.1 nTPM
Lymph node	24.4 nTPM
Liver	21.3 nTPM
Kidney	14.3 nTPM

Dendritic cells	36.0 nTPM
Breast	44.8 nTPM
Adipose tissue	39.3 nTPM
PBMC	23.9 nTPM

Endothelial cells	43.6 nTPM
Pancreas	96.5 nTPM
Ovary	69.6 nTPM
Esophagus	68.8 nTPM
Placenta	64.8 nTPM
Prostate	52.6 nTPM
Breast	50.8 nTPM
Liver	40.3 nTPM
Endometrium	37.8 nTPM
Testis	34.4 nTPM
Skin	29.6 nTPM
Skeletal muscle	25.1 nTPM
Eye	20.3 nTPM
Heart muscle	13.8 nTPM
Lung	6.2 nTPM

Fibroblasts	26.1 nTPM
Placenta	55.9 nTPM
Adipose tissue	42.5 nTPM
Breast	29.0 nTPM
Ovary	28.2 nTPM
Stomach	28.2 nTPM
Esophagus	24.0 nTPM
Skeletal muscle	22.9 nTPM
Skin	21.9 nTPM
Prostate	20.5 nTPM
Heart muscle	6.9 nTPM
Lung	6.7 nTPM

Intestinal goblet cells	33.8 nTPM
Colon	38.6 nTPM
Small intestine	33.3 nTPM
Rectum	29.6 nTPM

Macrophages	41.5 nTPM
Pancreas	76.5 nTPM
Ovary	56.9 nTPM
Breast	55.5 nTPM
Stomach	49.8 nTPM
Adipose tissue	48.8 nTPM
Testis	47.7 nTPM
Kidney	47.6 nTPM
Esophagus	37.7 nTPM
Skeletal muscle	34.5 nTPM
Spleen	34.2 nTPM
Endometrium	33.4 nTPM
Prostate	29.8 nTPM
PBMC	27.3 nTPM
Bone marrow	25.0 nTPM
Lung	17.1 nTPM

Paneth cells	63.9 nTPM
Colon	105.4 nTPM
Rectum	44.9 nTPM
Small intestine	41.3 nTPM

Plasma cells	19.0 nTPM
Bone marrow	26.4 nTPM
Spleen	21.1 nTPM
Stomach	20.8 nTPM
Adipose tissue	20.6 nTPM
Esophagus	6.1 nTPM

Respiratory ciliated cells	14.5 nTPM
Bronchus	23.2 nTPM
Lung	5.8 nTPM

Smooth muscle cells	39.7 nTPM
Pancreas	126.2 nTPM
Bronchus	89.9 nTPM
Ovary	62.9 nTPM
Breast	28.9 nTPM
Adipose tissue	28.4 nTPM
Esophagus	23.3 nTPM
Endometrium	22.1 nTPM
Prostate	17.2 nTPM
Skin	15.3 nTPM
Skeletal muscle	12.0 nTPM
Heart muscle	10.4 nTPM

T-cells	31.5 nTPM
Stomach	49.1 nTPM
Esophagus	45.9 nTPM
Bone marrow	42.5 nTPM
Ovary	40.0 nTPM
Colon	37.6 nTPM
Kidney	36.9 nTPM
Adipose tissue	34.6 nTPM
Spleen	34.4 nTPM
Breast	33.5 nTPM
Lung	30.4 nTPM
Skin	27.1 nTPM
Liver	26.5 nTPM
Skeletal muscle	22.9 nTPM
Endometrium	20.8 nTPM
Prostate	19.0 nTPM
Lymph node	17.8 nTPM
PBMC	16.7 nTPM

Basal keratinocytes	15.6 nTPM
Skin	15.6 nTPM

Basal prostatic cells	25.9 nTPM
Prostate	25.9 nTPM

Basal respiratory cells	61.1 nTPM
Bronchus	61.1 nTPM

Cholangiocytes	34.3 nTPM
Liver	34.3 nTPM

Undifferentiated cells	47.2 nTPM
Colon	64.9 nTPM
Small intestine	38.7 nTPM
Rectum	38.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC