Single cell type - ATXN3 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ATXN3
Gene descriptionⁱ Full gene name according to HGNC.	Ataxin 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	19

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ATXN3 is part of cluster 52 Non-specific - Transcription with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CEP68	Centrosomal protein 68	0.5649	14
ZBTB8A	Zinc finger and BTB domain containing 8A	0.5331	36
PPM1F	Protein phosphatase, Mg2+/Mn2+ dependent 1F	0.5213	14
MAP3K3	Mitogen-activated protein kinase kinase kinase 3	0.5138	19
ZNF559	Zinc finger protein 559	0.5105	52
ZNF502	Zinc finger protein 502	0.4954	20
MPHOSPH8	M-phase phosphoprotein 8	0.4751	52
RBMX2	RNA binding motif protein X-linked 2	0.4714	32
POLR2J3	RNA polymerase II subunit J3	0.4618	52
ZNF557	Zinc finger protein 557	0.4509	52
NRDE2	NRDE-2, necessary for RNA interference, domain containing	0.4471	52
BBS10	Bardet-Biedl syndrome 10	0.4468	50
ZNF333	Zinc finger protein 333	0.4459	52
GIMAP8	GTPase, IMAP family member 8	0.4451	14
INMT	Indolethylamine N-methyltransferase	0.4336	14

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	55.0 nTPM
Adipose tissue	57.1 nTPM
Breast	53.0 nTPM

Alveolar cells type 1	16.0 nTPM
Lung	16.0 nTPM

Alveolar cells type 2	12.4 nTPM
Lung	12.4 nTPM

Astrocytes	33.6 nTPM
Brain	33.6 nTPM

B-cells	27.6 nTPM
PBMC	42.8 nTPM
Colon	39.9 nTPM
Bone marrow	29.4 nTPM
Lymph node	29.2 nTPM
Spleen	27.6 nTPM
Stomach	25.5 nTPM
Adipose tissue	25.1 nTPM
Liver	23.1 nTPM
Breast	18.7 nTPM
Kidney	14.3 nTPM

Dendritic cells	31.5 nTPM
PBMC	35.8 nTPM
Adipose tissue	31.4 nTPM
Breast	27.4 nTPM

Endothelial cells	53.0 nTPM
Testis	110.0 nTPM
Liver	77.1 nTPM
Skeletal muscle	61.6 nTPM
Placenta	60.3 nTPM
Heart muscle	57.7 nTPM
Prostate	50.2 nTPM
Ovary	48.2 nTPM
Endometrium	47.7 nTPM
Skin	47.0 nTPM
Esophagus	43.4 nTPM
Eye	37.2 nTPM
Breast	36.4 nTPM
Pancreas	34.7 nTPM
Lung	31.2 nTPM

Fibroblasts	34.6 nTPM
Skeletal muscle	56.9 nTPM
Adipose tissue	47.5 nTPM
Heart muscle	43.7 nTPM
Esophagus	35.1 nTPM
Breast	35.1 nTPM
Prostate	31.8 nTPM
Placenta	28.6 nTPM
Lung	26.8 nTPM
Skin	26.5 nTPM
Ovary	24.4 nTPM
Stomach	23.7 nTPM

Intestinal goblet cells	16.4 nTPM
Rectum	21.2 nTPM
Small intestine	16.5 nTPM
Colon	11.4 nTPM

Macrophages	30.0 nTPM
Testis	44.7 nTPM
Adipose tissue	42.4 nTPM
Lung	41.7 nTPM
Skeletal muscle	37.5 nTPM
Ovary	36.6 nTPM
Kidney	35.6 nTPM
Prostate	34.4 nTPM
Breast	34.4 nTPM
Endometrium	33.8 nTPM
Bone marrow	28.7 nTPM
Stomach	23.5 nTPM
Pancreas	20.4 nTPM
Esophagus	18.9 nTPM
Spleen	17.6 nTPM
PBMC	0.0 nTPM

Paneth cells	16.1 nTPM
Rectum	26.2 nTPM
Small intestine	18.8 nTPM
Colon	3.3 nTPM

Plasma cells	20.1 nTPM
Esophagus	24.6 nTPM
Adipose tissue	22.5 nTPM
Spleen	20.5 nTPM
Bone marrow	18.2 nTPM
Stomach	14.7 nTPM

Respiratory ciliated cells	16.0 nTPM
Bronchus	18.9 nTPM
Lung	13.1 nTPM

Smooth muscle cells	38.2 nTPM
Skeletal muscle	61.8 nTPM
Heart muscle	54.0 nTPM
Adipose tissue	49.8 nTPM
Endometrium	41.6 nTPM
Breast	41.0 nTPM
Skin	39.7 nTPM
Prostate	34.4 nTPM
Esophagus	32.5 nTPM
Ovary	31.8 nTPM
Pancreas	22.8 nTPM
Bronchus	11.2 nTPM

T-cells	28.8 nTPM
Skeletal muscle	47.8 nTPM
PBMC	46.6 nTPM
Colon	42.3 nTPM
Adipose tissue	33.0 nTPM
Breast	32.5 nTPM
Lymph node	32.3 nTPM
Liver	32.0 nTPM
Ovary	31.1 nTPM
Skin	30.9 nTPM
Lung	25.8 nTPM
Kidney	24.7 nTPM
Prostate	23.6 nTPM
Endometrium	23.4 nTPM
Bone marrow	21.6 nTPM
Stomach	18.2 nTPM
Spleen	17.6 nTPM
Esophagus	6.6 nTPM

Basal keratinocytes	25.4 nTPM
Skin	25.4 nTPM

Basal respiratory cells	29.8 nTPM
Bronchus	29.8 nTPM

Basal squamous epithelial cells	19.4 nTPM
Esophagus	19.4 nTPM

Cholangiocytes	15.7 nTPM
Liver	15.7 nTPM

Undifferentiated cells	18.9 nTPM
Rectum	22.9 nTPM
Small intestine	17.9 nTPM
Colon	16.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC