Single cell type - ZNF502 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ZNF502
Gene descriptionⁱ Full gene name according to HGNC.	Zinc finger protein 502
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatogonia & Spermatocytes - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Spermatogonia, Rod photoreceptor cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Spermatogonia, Rod photoreceptor cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ZNF502 is part of cluster 20 Spermatogonia & Spermatocytes - Spermatogenesis with confidenceⁱ 1
181 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ZNF559	Zinc finger protein 559	0.5901	52
HPS4	HPS4 biogenesis of lysosomal organelles complex 3 subunit 2	0.5357	52
ZNF665	Zinc finger protein 665	0.5203	11
PALB2	Partner and localizer of BRCA2	0.5193	13
PHF24	PHD finger protein 24	0.5084	5
YY2	YY2 transcription factor	0.5054	20
GAGE12F	G antigen 12F	0.4979	20
DOC2B	Double C2 domain beta	0.4969	5
PNMA5	PNMA family member 5	0.4957	20
ATXN3	Ataxin 3	0.4954	52
POLR2J3	RNA polymerase II subunit J3	0.4935	52
KLHL35	Kelch like family member 35	0.4902	20
ZIC3	Zic family member 3	0.4898	5
TMEM221	Transmembrane protein 221	0.4884	5
SSX3	SSX family member 3	0.4883	20

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	4.0 nTPM
Breast	4.1 nTPM
Adipose tissue	3.9 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	5.1 nTPM
Lung	5.1 nTPM

Astrocytes	3.3 nTPM
Brain	3.3 nTPM

B-cells	3.9 nTPM
Spleen	6.5 nTPM
PBMC	5.7 nTPM
Kidney	4.8 nTPM
Stomach	4.1 nTPM
Liver	3.5 nTPM
Lymph node	3.3 nTPM
Colon	3.2 nTPM
Bone marrow	3.2 nTPM
Breast	2.6 nTPM
Adipose tissue	2.0 nTPM

Dendritic cells	3.3 nTPM
PBMC	4.0 nTPM
Adipose tissue	3.0 nTPM
Breast	2.9 nTPM

Endothelial cells	5.4 nTPM
Pancreas	11.6 nTPM
Testis	9.5 nTPM
Liver	9.2 nTPM
Heart muscle	8.4 nTPM
Lung	6.2 nTPM
Esophagus	6.2 nTPM
Skeletal muscle	4.9 nTPM
Breast	4.2 nTPM
Ovary	3.4 nTPM
Endometrium	2.8 nTPM
Eye	2.4 nTPM
Skin	2.4 nTPM
Placenta	2.2 nTPM
Prostate	2.2 nTPM

Fibroblasts	3.2 nTPM
Stomach	6.0 nTPM
Skeletal muscle	4.6 nTPM
Ovary	4.4 nTPM
Esophagus	4.1 nTPM
Adipose tissue	3.8 nTPM
Breast	3.6 nTPM
Placenta	3.2 nTPM
Prostate	1.9 nTPM
Skin	1.6 nTPM
Heart muscle	1.2 nTPM
Lung	1.2 nTPM

Intestinal goblet cells	1.6 nTPM
Rectum	2.6 nTPM
Small intestine	1.4 nTPM
Colon	0.7 nTPM

Macrophages	1.0 nTPM
Lung	3.2 nTPM
Bone marrow	2.5 nTPM
Skeletal muscle	1.9 nTPM
Breast	1.8 nTPM
Prostate	1.2 nTPM
Spleen	1.0 nTPM
Ovary	0.9 nTPM
Adipose tissue	0.9 nTPM
Kidney	0.8 nTPM
Testis	0.6 nTPM
Endometrium	0.6 nTPM
PBMC	0.0 nTPM
Pancreas	0.0 nTPM
Esophagus	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	1.1 nTPM
Rectum	3.4 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Plasma cells	0.5 nTPM
Adipose tissue	1.3 nTPM
Spleen	0.6 nTPM
Stomach	0.4 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM

Respiratory ciliated cells	3.1 nTPM
Lung	4.4 nTPM
Bronchus	1.8 nTPM

Smooth muscle cells	2.8 nTPM
Adipose tissue	6.2 nTPM
Skeletal muscle	4.8 nTPM
Ovary	3.3 nTPM
Endometrium	3.2 nTPM
Breast	3.2 nTPM
Esophagus	3.1 nTPM
Pancreas	2.5 nTPM
Skin	2.4 nTPM
Prostate	1.3 nTPM
Heart muscle	1.2 nTPM
Bronchus	0.0 nTPM

T-cells	1.9 nTPM
Esophagus	6.6 nTPM
PBMC	6.4 nTPM
Bone marrow	2.6 nTPM
Skin	1.9 nTPM
Liver	1.8 nTPM
Skeletal muscle	1.8 nTPM
Lymph node	1.7 nTPM
Stomach	1.7 nTPM
Spleen	1.5 nTPM
Breast	1.5 nTPM
Kidney	1.4 nTPM
Endometrium	1.4 nTPM
Adipose tissue	1.1 nTPM
Colon	1.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Ovary	0.0 nTPM

Collecting duct cells	3.7 nTPM
Kidney	3.7 nTPM

Undifferentiated cells	3.0 nTPM
Rectum	4.1 nTPM
Small intestine	3.6 nTPM
Colon	1.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC