Single cell type - ISOC1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ISOC1
Gene descriptionⁱ Full gene name according to HGNC.	Isochorismatase domain containing 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Basal keratinocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (SH-SY5Y)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Basal keratinocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ISOC1 is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 1
586 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PEBP1	Phosphatidylethanolamine binding protein 1	0.5816	67
TFB2M	Transcription factor B2, mitochondrial	0.5251	67
NUDT7	Nudix hydrolase 7	0.5208	39
GRPEL1	GrpE like 1, mitochondrial	0.5201	39
MRPS26	Mitochondrial ribosomal protein S26	0.5074	39
NDUFAF4	NADH:ubiquinone oxidoreductase complex assembly factor 4	0.5019	39
ECHDC3	Enoyl-CoA hydratase domain containing 3	0.5009	67
HNRNPDL	Heterogeneous nuclear ribonucleoprotein D like	0.4982	39
LCE1C	Late cornified envelope 1C	0.4967	28
COA4	Cytochrome c oxidase assembly factor 4 homolog	0.4943	39
ADI1	Acireductone dioxygenase 1	0.4909	67
PMVK	Phosphomevalonate kinase	0.4857	47
ECI2	Enoyl-CoA delta isomerase 2	0.4805	67
MOCS2	Molybdenum cofactor synthesis 2	0.4750	39
NIPSNAP1	Nipsnap homolog 1	0.4722	67

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	58.1 nTPM
Adipose tissue	64.1 nTPM
Breast	52.1 nTPM

Alveolar cells type 1	12.8 nTPM
Lung	12.8 nTPM

Alveolar cells type 2	17.2 nTPM
Lung	17.2 nTPM

Astrocytes	6.5 nTPM
Brain	6.5 nTPM

B-cells	18.9 nTPM
Liver	34.0 nTPM
Breast	22.8 nTPM
Stomach	22.7 nTPM
Colon	22.3 nTPM
Bone marrow	21.3 nTPM
Spleen	21.1 nTPM
Lymph node	20.5 nTPM
Adipose tissue	13.5 nTPM
PBMC	5.7 nTPM
Kidney	4.8 nTPM

Dendritic cells	26.3 nTPM
Breast	39.3 nTPM
Adipose tissue	27.7 nTPM
PBMC	12.0 nTPM

Endothelial cells	16.9 nTPM
Skeletal muscle	60.1 nTPM
Breast	30.6 nTPM
Heart muscle	24.9 nTPM
Placenta	24.5 nTPM
Ovary	22.3 nTPM
Skin	20.9 nTPM
Prostate	11.3 nTPM
Liver	10.1 nTPM
Esophagus	8.3 nTPM
Endometrium	7.9 nTPM
Testis	6.5 nTPM
Eye	4.8 nTPM
Pancreas	3.9 nTPM
Lung	0.0 nTPM

Fibroblasts	33.9 nTPM
Ovary	76.2 nTPM
Prostate	53.6 nTPM
Heart muscle	47.0 nTPM
Placenta	36.2 nTPM
Stomach	35.6 nTPM
Esophagus	35.4 nTPM
Skin	27.0 nTPM
Lung	21.2 nTPM
Breast	18.7 nTPM
Adipose tissue	12.1 nTPM
Skeletal muscle	10.2 nTPM

Intestinal goblet cells	26.6 nTPM
Small intestine	35.0 nTPM
Rectum	25.6 nTPM
Colon	19.3 nTPM

Macrophages	14.3 nTPM
Kidney	24.9 nTPM
Pancreas	23.0 nTPM
Stomach	20.5 nTPM
Breast	19.2 nTPM
Spleen	15.6 nTPM
Adipose tissue	15.3 nTPM
Ovary	14.1 nTPM
Prostate	13.8 nTPM
PBMC	13.6 nTPM
Endometrium	12.3 nTPM
Skeletal muscle	10.4 nTPM
Bone marrow	10.0 nTPM
Esophagus	9.4 nTPM
Lung	7.3 nTPM
Testis	5.2 nTPM

Paneth cells	29.8 nTPM
Rectum	36.3 nTPM
Small intestine	30.0 nTPM
Colon	23.1 nTPM

Plasma cells	36.9 nTPM
Esophagus	61.7 nTPM
Stomach	49.7 nTPM
Spleen	36.3 nTPM
Bone marrow	24.7 nTPM
Adipose tissue	12.2 nTPM

Respiratory ciliated cells	10.6 nTPM
Bronchus	14.0 nTPM
Lung	7.3 nTPM

Smooth muscle cells	15.9 nTPM
Ovary	29.3 nTPM
Endometrium	24.0 nTPM
Skin	22.3 nTPM
Prostate	19.6 nTPM
Heart muscle	16.7 nTPM
Breast	14.8 nTPM
Pancreas	12.8 nTPM
Skeletal muscle	11.3 nTPM
Adipose tissue	10.6 nTPM
Esophagus	9.3 nTPM
Bronchus	3.9 nTPM

T-cells	26.4 nTPM
Ovary	40.0 nTPM
Skin	39.6 nTPM
Breast	39.0 nTPM
Kidney	32.9 nTPM
Esophagus	32.8 nTPM
Adipose tissue	31.9 nTPM
Stomach	29.3 nTPM
Spleen	26.6 nTPM
Colon	23.3 nTPM
Liver	22.7 nTPM
Bone marrow	22.5 nTPM
Lymph node	22.1 nTPM
Endometrium	20.6 nTPM
Skeletal muscle	19.1 nTPM
Lung	18.2 nTPM
PBMC	14.3 nTPM
Prostate	14.2 nTPM

Basal keratinocytes	131.8 nTPM
Skin	131.8 nTPM

Basal prostatic cells	42.4 nTPM
Prostate	42.4 nTPM

Basal respiratory cells	28.5 nTPM
Bronchus	28.5 nTPM

Basal squamous epithelial cells	88.2 nTPM
Esophagus	88.2 nTPM

Undifferentiated cells	32.8 nTPM
Small intestine	39.1 nTPM
Rectum	32.6 nTPM
Colon	26.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC