Single cell type - TFB2M - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TFB2M
Gene descriptionⁱ Full gene name according to HGNC.	Transcription factor B2, mitochondrial
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Proximal tubular cells - Tubular reabsorption (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TFB2M is part of cluster 67 Proximal tubular cells - Tubular reabsorption with confidenceⁱ 1
499 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
LCE1C	Late cornified envelope 1C	0.6354	28
MT1X	Metallothionein 1X	0.6330	67
PSAT1	Phosphoserine aminotransferase 1	0.6233	67
NDUFAF4	NADH:ubiquinone oxidoreductase complex assembly factor 4	0.5817	39
SHMT1	Serine hydroxymethyltransferase 1	0.5755	67
MCAT	Malonyl-CoA-acyl carrier protein transacylase	0.5752	67
AK4	Adenylate kinase 4	0.5582	67
HOXC10	Homeobox C10	0.5513	67
HPD	4-hydroxyphenylpyruvate dioxygenase	0.5511	67
PNPLA4	Patatin like phospholipase domain containing 4	0.5501	67
ECHS1	Enoyl-CoA hydratase, short chain 1	0.5487	67
UGT2B7	UDP glucuronosyltransferase family 2 member B7	0.5426	67
SLC2A9	Solute carrier family 2 member 9	0.5417	67
GRHPR	Glyoxylate and hydroxypyruvate reductase	0.5412	67
MRPL19	Mitochondrial ribosomal protein L19	0.5366	39

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	11.9 nTPM
Adipose tissue	12.0 nTPM
Breast	11.7 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	9.4 nTPM
Lung	9.4 nTPM

Astrocytes	4.2 nTPM
Brain	4.2 nTPM

B-cells	17.2 nTPM
Lymph node	25.6 nTPM
Stomach	24.1 nTPM
Bone marrow	22.9 nTPM
Spleen	20.1 nTPM
PBMC	17.1 nTPM
Liver	15.6 nTPM
Breast	13.4 nTPM
Adipose tissue	13.0 nTPM
Colon	11.2 nTPM
Kidney	9.5 nTPM

Dendritic cells	13.1 nTPM
Breast	14.6 nTPM
Adipose tissue	12.6 nTPM
PBMC	12.0 nTPM

Endothelial cells	13.2 nTPM
Pancreas	23.1 nTPM
Endometrium	20.5 nTPM
Skin	17.9 nTPM
Prostate	17.3 nTPM
Placenta	15.3 nTPM
Esophagus	14.5 nTPM
Ovary	13.3 nTPM
Lung	12.5 nTPM
Skeletal muscle	11.7 nTPM
Breast	9.8 nTPM
Heart muscle	9.1 nTPM
Testis	7.4 nTPM
Liver	6.4 nTPM
Eye	5.7 nTPM

Fibroblasts	10.2 nTPM
Placenta	17.0 nTPM
Prostate	17.0 nTPM
Skin	11.5 nTPM
Ovary	11.1 nTPM
Adipose tissue	11.0 nTPM
Breast	10.6 nTPM
Skeletal muscle	10.3 nTPM
Esophagus	9.9 nTPM
Stomach	7.4 nTPM
Lung	3.4 nTPM
Heart muscle	2.7 nTPM

Intestinal goblet cells	14.3 nTPM
Rectum	18.2 nTPM
Colon	15.0 nTPM
Small intestine	9.7 nTPM

Macrophages	7.3 nTPM
Stomach	11.7 nTPM
Breast	11.3 nTPM
Kidney	10.6 nTPM
Prostate	9.1 nTPM
Testis	8.8 nTPM
Bone marrow	8.7 nTPM
Lung	8.1 nTPM
Spleen	7.2 nTPM
Endometrium	6.8 nTPM
Adipose tissue	6.2 nTPM
Skeletal muscle	6.0 nTPM
Ovary	5.5 nTPM
Pancreas	5.1 nTPM
Esophagus	4.8 nTPM
PBMC	0.0 nTPM

Paneth cells	10.3 nTPM
Rectum	17.4 nTPM
Colon	9.9 nTPM
Small intestine	3.7 nTPM

Plasma cells	12.7 nTPM
Stomach	21.1 nTPM
Spleen	19.5 nTPM
Bone marrow	14.8 nTPM
Esophagus	6.1 nTPM
Adipose tissue	1.9 nTPM

Respiratory ciliated cells	15.4 nTPM
Bronchus	22.1 nTPM
Lung	8.7 nTPM

Smooth muscle cells	12.2 nTPM
Prostate	21.3 nTPM
Pancreas	20.5 nTPM
Skin	17.0 nTPM
Ovary	13.5 nTPM
Esophagus	12.4 nTPM
Skeletal muscle	10.6 nTPM
Endometrium	10.3 nTPM
Heart muscle	8.4 nTPM
Breast	8.1 nTPM
Adipose tissue	7.7 nTPM
Bronchus	4.7 nTPM

T-cells	10.9 nTPM
Lymph node	16.6 nTPM
Ovary	15.6 nTPM
Liver	14.1 nTPM
Esophagus	13.1 nTPM
Stomach	13.0 nTPM
Breast	12.7 nTPM
Colon	11.9 nTPM
Endometrium	11.3 nTPM
Spleen	10.9 nTPM
PBMC	10.6 nTPM
Adipose tissue	10.5 nTPM
Bone marrow	9.6 nTPM
Prostate	9.5 nTPM
Skeletal muscle	7.7 nTPM
Skin	6.9 nTPM
Lung	6.1 nTPM
Kidney	5.5 nTPM

Basal keratinocytes	53.3 nTPM
Skin	53.3 nTPM

Basal prostatic cells	13.7 nTPM
Prostate	13.7 nTPM

Basal respiratory cells	27.9 nTPM
Bronchus	27.9 nTPM

Basal squamous epithelial cells	31.9 nTPM
Esophagus	31.9 nTPM

Undifferentiated cells	19.8 nTPM
Small intestine	21.2 nTPM
Colon	19.9 nTPM
Rectum	18.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC