Single cell type - RASGRP2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RASGRP2
Gene descriptionⁱ Full gene name according to HGNC.	RAS guanyl releasing protein 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes Plasma proteins RAS pathway related proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	14

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	B-cells - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Sertoli cells, B-cells, NK-cells, dendritic cells, Kupffer cells, Macrophages)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HEL, HL-60, NB-4, REH, THP-1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Sertoli cells, B-cells, NK-cells, dendritic cells, Kupffer cells, Macrophages)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

RASGRP2 is part of cluster 57 B-cells - Immune response with confidenceⁱ 1
204 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
LIMD2	LIM domain containing 2	0.6856	63
SELL	Selectin L	0.6466	63
CSK	C-terminal Src kinase	0.6459	57
GPSM3	G protein signaling modulator 3	0.6321	63
PADI4	Peptidyl arginine deiminase 4	0.6208	19
RCSD1	RCSD domain containing 1	0.6102	57
CD52	CD52 molecule	0.6042	57
MAP3K7CL	MAP3K7 C-terminal like	0.5993	51
CDKN2D	Cyclin dependent kinase inhibitor 2D	0.5865	51
LTB	Lymphotoxin beta	0.5781	63
LBH	LBH regulator of WNT signaling pathway	0.5702	48
POU2F2	POU class 2 homeobox 2	0.5678	57
CCND3	Cyclin D3	0.5650	51
LPAR5	Lysophosphatidic acid receptor 5	0.5630	51
HACD4	3-hydroxyacyl-CoA dehydratase 4	0.5622	51

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	27.4 nTPM
Breast	33.1 nTPM
Adipose tissue	21.7 nTPM

Alveolar cells type 1	3.2 nTPM
Lung	3.2 nTPM

Alveolar cells type 2	1.8 nTPM
Lung	1.8 nTPM

Astrocytes	2.6 nTPM
Brain	2.6 nTPM

Basal keratinocytes	2.3 nTPM
Skin	2.3 nTPM

B-cells	125.5 nTPM
PBMC	181.3 nTPM
Adipose tissue	142.3 nTPM
Kidney	138.0 nTPM
Stomach	137.1 nTPM
Lymph node	129.7 nTPM
Bone marrow	123.4 nTPM
Spleen	115.6 nTPM
Colon	115.0 nTPM
Breast	104.3 nTPM
Liver	68.5 nTPM

Dendritic cells	86.1 nTPM
Breast	116.6 nTPM
Adipose tissue	74.0 nTPM
PBMC	67.8 nTPM

Endothelial cells	13.5 nTPM
Eye	53.4 nTPM
Heart muscle	26.5 nTPM
Skeletal muscle	25.8 nTPM
Breast	21.2 nTPM
Placenta	12.5 nTPM
Ovary	8.8 nTPM
Liver	8.2 nTPM
Skin	7.5 nTPM
Testis	7.4 nTPM
Lung	6.2 nTPM
Esophagus	4.6 nTPM
Endometrium	3.8 nTPM
Prostate	2.6 nTPM
Pancreas	0.0 nTPM

Fibroblasts	6.6 nTPM
Heart muscle	19.7 nTPM
Stomach	13.4 nTPM
Placenta	8.6 nTPM
Ovary	7.9 nTPM
Breast	7.3 nTPM
Prostate	5.7 nTPM
Skin	3.5 nTPM
Esophagus	3.2 nTPM
Lung	2.2 nTPM
Skeletal muscle	1.2 nTPM
Adipose tissue	0.2 nTPM

Intestinal goblet cells	0.1 nTPM
Small intestine	0.4 nTPM
Colon	0.0 nTPM
Rectum	0.0 nTPM

Macrophages	72.2 nTPM
PBMC	409.2 nTPM
Stomach	108.4 nTPM
Bone marrow	105.0 nTPM
Kidney	90.0 nTPM
Spleen	67.4 nTPM
Adipose tissue	52.5 nTPM
Skeletal muscle	48.0 nTPM
Testis	44.7 nTPM
Prostate	40.1 nTPM
Breast	32.9 nTPM
Esophagus	26.8 nTPM
Lung	24.1 nTPM
Endometrium	22.5 nTPM
Ovary	6.4 nTPM
Pancreas	5.1 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Plasma cells	28.6 nTPM
Bone marrow	61.0 nTPM
Adipose tissue	53.5 nTPM
Spleen	17.9 nTPM
Esophagus	6.1 nTPM
Stomach	4.4 nTPM

Respiratory ciliated cells	0.7 nTPM
Lung	1.5 nTPM
Bronchus	0.0 nTPM

Smooth muscle cells	56.8 nTPM
Breast	105.2 nTPM
Prostate	88.5 nTPM
Esophagus	85.3 nTPM
Skin	82.7 nTPM
Heart muscle	79.1 nTPM
Skeletal muscle	68.9 nTPM
Endometrium	46.8 nTPM
Ovary	35.9 nTPM
Adipose tissue	29.0 nTPM
Pancreas	3.3 nTPM
Bronchus	0.0 nTPM

Cholangiocytes	2.8 nTPM
Liver	2.8 nTPM

Cytotrophoblasts	1.7 nTPM
Placenta	1.7 nTPM

Endometrial stromal cells	27.1 nTPM
Endometrium	27.1 nTPM

Excitatory neurons	6.0 nTPM
Brain	6.0 nTPM

T-cells	61.0 nTPM
PBMC	125.0 nTPM
Ovary	115.7 nTPM
Lymph node	107.9 nTPM
Kidney	89.0 nTPM
Adipose tissue	81.3 nTPM
Liver	75.2 nTPM
Spleen	74.8 nTPM
Bone marrow	71.1 nTPM
Skeletal muscle	61.5 nTPM
Breast	50.9 nTPM
Prostate	42.6 nTPM
Skin	33.7 nTPM
Stomach	33.1 nTPM
Lung	22.8 nTPM
Esophagus	19.7 nTPM
Colon	18.1 nTPM
Endometrium	14.6 nTPM

Undifferentiated cells	0.3 nTPM
Small intestine	0.4 nTPM
Colon	0.3 nTPM
Rectum	0.2 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC