Single cell type - ABCC9 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ABCC9
Gene descriptionⁱ Full gene name according to HGNC.	ATP binding cassette subfamily C member 9
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes FDA approved drug targets Human disease related genes Metabolic proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Smooth muscle cells - ECM organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Smooth muscle cells, Sertoli cells, Hepatocytes, Astrocytes, Alveolar cells type 2)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Not detected in immune cells
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Not detected
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (ASC diff, BJ hTERT+, CACO-2, HSkMC, U-138 MG)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Smooth muscle cells, Sertoli cells, Hepatocytes, Astrocytes, Alveolar cells type 2)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ABCC9 is part of cluster 48 Smooth muscle cells - ECM organization with confidenceⁱ 1
270 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
KCNJ8	Potassium inwardly rectifying channel subfamily J member 8	0.8177	48
AVPR1A	Arginine vasopressin receptor 1A	0.7746	48
SCN4B	Sodium voltage-gated channel beta subunit 4	0.7528	48
REM1	RRAD and GEM like GTPase 1	0.7398	48
MYLK	Myosin light chain kinase	0.7157	48
NOTCH3	Notch receptor 3	0.7096	48
LMOD1	Leiomodin 1	0.7030	48
GJC1	Gap junction protein gamma 1	0.7010	48
RERGL	RERG like	0.6920	48
KCNE4	Potassium voltage-gated channel subfamily E regulatory subunit 4	0.6818	48
ITGA7	Integrin subunit alpha 7	0.6716	48
LGI4	Leucine rich repeat LGI family member 4	0.6701	48
MYH11	Myosin heavy chain 11	0.6700	48
AOC3	Amine oxidase copper containing 3	0.6700	48
ARHGEF17	Rho guanine nucleotide exchange factor 17	0.6626	48

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	33.8 nTPM
Breast	59.5 nTPM
Adipose tissue	8.0 nTPM

Alveolar cells type 1	35.3 nTPM
Lung	35.3 nTPM

B-cells	0.2 nTPM
Liver	1.3 nTPM
Bone marrow	0.8 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM
Lymph node	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Breast	0.0 nTPM

Basal keratinocytes	3.4 nTPM
Skin	3.4 nTPM

Basal prostatic cells	1.5 nTPM
Prostate	1.5 nTPM

Dendritic cells	0.0 nTPM
Adipose tissue	0.1 nTPM
PBMC	0.0 nTPM
Breast	0.0 nTPM

Endothelial cells	19.7 nTPM
Eye	123.8 nTPM
Heart muscle	41.3 nTPM
Breast	27.5 nTPM
Skeletal muscle	26.5 nTPM
Lung	24.9 nTPM
Skin	19.0 nTPM
Prostate	5.6 nTPM
Testis	3.3 nTPM
Endometrium	3.3 nTPM
Ovary	0.7 nTPM
Esophagus	0.6 nTPM
Liver	0.0 nTPM
Placenta	0.0 nTPM
Pancreas	0.0 nTPM

Fibroblasts	26.2 nTPM
Adipose tissue	54.0 nTPM
Esophagus	39.3 nTPM
Lung	38.0 nTPM
Skeletal muscle	37.2 nTPM
Heart muscle	36.7 nTPM
Stomach	26.7 nTPM
Skin	25.6 nTPM
Prostate	16.5 nTPM
Breast	11.5 nTPM
Placenta	2.4 nTPM
Ovary	0.7 nTPM

Intestinal goblet cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Macrophages	2.5 nTPM
Lung	24.7 nTPM
Skeletal muscle	8.3 nTPM
Testis	2.9 nTPM
Endometrium	1.4 nTPM
Breast	0.4 nTPM
Adipose tissue	0.2 nTPM
Kidney	0.0 nTPM
Prostate	0.0 nTPM
PBMC	0.0 nTPM
Pancreas	0.0 nTPM
Ovary	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Plasma cells	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Respiratory ciliated cells	20.4 nTPM
Lung	39.4 nTPM
Bronchus	1.5 nTPM

Smooth muscle cells	140.7 nTPM
Adipose tissue	421.8 nTPM
Heart muscle	383.5 nTPM
Skeletal muscle	323.8 nTPM
Breast	108.0 nTPM
Endometrium	92.3 nTPM
Skin	84.3 nTPM
Esophagus	55.8 nTPM
Prostate	53.2 nTPM
Ovary	19.7 nTPM
Pancreas	5.0 nTPM
Bronchus	0.0 nTPM

T-cells	2.5 nTPM
Lung	34.9 nTPM
Skin	2.3 nTPM
Skeletal muscle	2.3 nTPM
Endometrium	1.2 nTPM
Liver	0.7 nTPM
Bone marrow	0.4 nTPM
Stomach	0.4 nTPM
Breast	0.4 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
Prostate	0.0 nTPM
PBMC	0.0 nTPM
Ovary	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Spleen	0.0 nTPM

Astrocytes	72.1 nTPM
Brain	72.1 nTPM

Cytotrophoblasts	0.3 nTPM
Placenta	0.3 nTPM

Endometrial stromal cells	20.6 nTPM
Endometrium	20.6 nTPM

Excitatory neurons	17.2 nTPM
Brain	17.2 nTPM

Undifferentiated cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC