Cell line - EIF2B3 - The Human Protein Atlas

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EIF2B3

SUMMARY

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BRAIN

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METABOLIC

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	EIF2B3
Gene descriptionⁱ Full gene name according to HGNC.	Eukaryotic translation initiation factor 2B subunit gamma
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Cell cycle regulation (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

CELL LINESⁱ

Organ

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

EIF2B3 is part of cluster 26 Non-specific - Cell cycle regulation with confidenceⁱ 1
1622 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
NUP153	Nucleoporin 153	0.7706	26
PA2G4	Proliferation-associated 2G4	0.7532	26
GEMIN5	Gem nuclear organelle associated protein 5	0.6706	26
NOL11	Nucleolar protein 11	0.6660	26
GSPT1	G1 to S phase transition 1	0.6573	26
SSX2IP	SSX family member 2 interacting protein	0.6569	26
C1orf109	Chromosome 1 open reading frame 109	0.6532	26
NAT10	N-acetyltransferase 10	0.6510	26
FARSB	Phenylalanyl-tRNA synthetase subunit beta	0.6478	26
RBBP5	RB binding protein 5, histone lysine methyltransferase complex subunit	0.6468	26
SLC25A17	Solute carrier family 25 member 17	0.6443	26
TIMM17A	Translocase of inner mitochondrial membrane 17A	0.6417	26
PPAT	Phosphoribosyl pyrophosphate amidotransferase	0.6320	26
NVL	Nuclear VCP like	0.6289	26
RBM28	RNA binding motif protein 28	0.6259	26

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.