Single cell type - WDR1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	WDR1
Gene descriptionⁱ Full gene name according to HGNC.	WD repeat domain 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatids - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

WDR1 is part of cluster 34 Spermatids - Unknown function with confidenceⁱ 1
366 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CAP1	Cyclase associated actin cytoskeleton regulatory protein 1	0.5884	16
CALM3	Calmodulin 3	0.5279	34
SERPINB6	Serpin family B member 6	0.5162	31
CFL1	Cofilin 1	0.5162	16
EIF5A2	Eukaryotic translation initiation factor 5A2	0.5157	34
SBDS	SBDS ribosome maturation factor	0.5115	31
C6orf89	Chromosome 6 open reading frame 89	0.5093	34
MEA1	Male-enhanced antigen 1	0.5015	31
COX8C	Cytochrome c oxidase subunit 8C	0.5012	34
RHOC	Ras homolog family member C	0.4921	16
C2orf88	Chromosome 2 open reading frame 88	0.4891	34
TNIP1	TNFAIP3 interacting protein 1	0.4888	53
SMIM6	Small integral membrane protein 6	0.4866	34
HMOX2	Heme oxygenase 2	0.4863	31
POLR3C	RNA polymerase III subunit C	0.4852	34

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	66.5 nTPM
Adipose tissue	69.9 nTPM
Breast	63.1 nTPM

Alveolar cells type 1	35.3 nTPM
Lung	35.3 nTPM

Alveolar cells type 2	52.9 nTPM
Lung	52.9 nTPM

Astrocytes	10.1 nTPM
Brain	10.1 nTPM

B-cells	77.0 nTPM
Stomach	103.1 nTPM
Spleen	91.3 nTPM
Liver	90.1 nTPM
Lymph node	89.7 nTPM
Bone marrow	81.7 nTPM
Colon	78.3 nTPM
Kidney	71.4 nTPM
PBMC	67.1 nTPM
Breast	53.6 nTPM
Adipose tissue	43.1 nTPM

Dendritic cells	126.7 nTPM
PBMC	167.4 nTPM
Breast	115.1 nTPM
Adipose tissue	97.6 nTPM

Endothelial cells	103.6 nTPM
Pancreas	289.5 nTPM
Ovary	191.6 nTPM
Placenta	131.9 nTPM
Prostate	116.5 nTPM
Esophagus	88.6 nTPM
Skin	88.3 nTPM
Skeletal muscle	80.7 nTPM
Testis	77.9 nTPM
Endometrium	74.2 nTPM
Lung	68.6 nTPM
Breast	63.8 nTPM
Liver	61.4 nTPM
Eye	59.9 nTPM
Heart muscle	57.0 nTPM

Enteroendocrine cells	109.2 nTPM
Colon	152.8 nTPM
Rectum	65.6 nTPM

Fibroblasts	68.7 nTPM
Stomach	126.2 nTPM
Ovary	102.5 nTPM
Lung	93.8 nTPM
Placenta	80.3 nTPM
Prostate	69.4 nTPM
Skin	68.2 nTPM
Skeletal muscle	52.0 nTPM
Adipose tissue	49.9 nTPM
Esophagus	49.9 nTPM
Breast	34.2 nTPM
Heart muscle	29.2 nTPM

Intestinal goblet cells	152.6 nTPM
Colon	220.2 nTPM
Rectum	120.2 nTPM
Small intestine	117.3 nTPM

Macrophages	174.9 nTPM
PBMC	491.1 nTPM
Pancreas	303.7 nTPM
Stomach	231.5 nTPM
Bone marrow	191.2 nTPM
Kidney	177.0 nTPM
Spleen	160.7 nTPM
Adipose tissue	156.7 nTPM
Prostate	133.0 nTPM
Lung	130.6 nTPM
Testis	127.3 nTPM
Esophagus	119.6 nTPM
Skeletal muscle	109.5 nTPM
Ovary	108.3 nTPM
Endometrium	98.8 nTPM
Breast	85.2 nTPM

Paneth cells	244.4 nTPM
Colon	457.8 nTPM
Rectum	151.5 nTPM
Small intestine	123.9 nTPM

Plasma cells	78.3 nTPM
Spleen	135.2 nTPM
Bone marrow	102.1 nTPM
Stomach	61.3 nTPM
Adipose tissue	49.7 nTPM
Esophagus	43.0 nTPM

Respiratory ciliated cells	73.5 nTPM
Bronchus	78.5 nTPM
Lung	68.5 nTPM

Smooth muscle cells	168.1 nTPM
Pancreas	390.5 nTPM
Esophagus	243.4 nTPM
Prostate	191.6 nTPM
Ovary	191.0 nTPM
Bronchus	164.8 nTPM
Skin	160.2 nTPM
Breast	149.9 nTPM
Heart muscle	103.7 nTPM
Skeletal muscle	92.8 nTPM
Endometrium	88.4 nTPM
Adipose tissue	73.0 nTPM

Basal keratinocytes	145.3 nTPM
Skin	145.3 nTPM

Basal prostatic cells	204.6 nTPM
Prostate	204.6 nTPM

Basal respiratory cells	103.5 nTPM
Bronchus	103.5 nTPM

Basal squamous epithelial cells	46.7 nTPM
Esophagus	46.7 nTPM

T-cells	132.2 nTPM
Stomach	260.7 nTPM
Bone marrow	219.8 nTPM
Spleen	179.3 nTPM
Kidney	156.7 nTPM
Liver	151.7 nTPM
Ovary	151.2 nTPM
Lymph node	149.2 nTPM
Colon	135.9 nTPM
Skin	134.5 nTPM
PBMC	122.1 nTPM
Skeletal muscle	113.4 nTPM
Prostate	89.9 nTPM
Esophagus	85.2 nTPM
Breast	80.0 nTPM
Adipose tissue	76.2 nTPM
Endometrium	75.5 nTPM
Lung	66.8 nTPM

Undifferentiated cells	172.8 nTPM
Colon	269.5 nTPM
Rectum	125.8 nTPM
Small intestine	123.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC