Single cell type - ATP6AP1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ATP6AP1
Gene descriptionⁱ Full gene name according to HGNC.	ATPase H+ transporting accessory protein 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Metabolic proteins Plasma proteins Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Macrophages - Innate immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ATP6AP1 is part of cluster 4 Macrophages - Innate immune response with confidenceⁱ 1
228 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
GRN	Granulin precursor	0.7535	4
HEXA	Hexosaminidase subunit alpha	0.7194	4
ATP6AP2	ATPase H+ transporting accessory protein 2	0.7155	4
PLD3	Phospholipase D family member 3	0.7153	4
CTSC	Cathepsin C	0.6861	26
DNASE2	Deoxyribonuclease 2, lysosomal	0.6630	4
CTSD	Cathepsin D	0.6616	4
FUCA1	Alpha-L-fucosidase 1	0.6511	4
BCAP31	B cell receptor associated protein 31	0.6422	47
GLB1	Galactosidase beta 1	0.6307	4
PSAP	Prosaposin	0.6293	4
NPC2	NPC intracellular cholesterol transporter 2	0.6238	4
CTSB	Cathepsin B	0.6211	4
TREM2	Triggering receptor expressed on myeloid cells 2	0.6063	4
CTSL	Cathepsin L	0.6021	4

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	39.4 nTPM
Adipose tissue	43.0 nTPM
Breast	35.9 nTPM

Alveolar cells type 1	38.5 nTPM
Lung	38.5 nTPM

Alveolar cells type 2	57.5 nTPM
Lung	57.5 nTPM

Astrocytes	17.0 nTPM
Brain	17.0 nTPM

B-cells	32.3 nTPM
Liver	57.3 nTPM
Kidney	57.1 nTPM
Colon	35.1 nTPM
PBMC	31.5 nTPM
Stomach	31.4 nTPM
Breast	28.1 nTPM
Spleen	25.3 nTPM
Lymph node	24.2 nTPM
Bone marrow	18.8 nTPM
Adipose tissue	14.6 nTPM

Dendritic cells	40.1 nTPM
PBMC	47.8 nTPM
Breast	36.4 nTPM
Adipose tissue	36.0 nTPM

Endothelial cells	50.1 nTPM
Placenta	87.0 nTPM
Pancreas	77.2 nTPM
Ovary	64.8 nTPM
Liver	64.2 nTPM
Eye	55.8 nTPM
Endometrium	44.2 nTPM
Lung	43.7 nTPM
Breast	43.4 nTPM
Testis	40.9 nTPM
Heart muscle	39.8 nTPM
Skeletal muscle	39.4 nTPM
Esophagus	35.5 nTPM
Skin	34.2 nTPM
Prostate	30.9 nTPM

Enteroendocrine cells	89.0 nTPM
Colon	110.1 nTPM
Rectum	67.9 nTPM

Fibroblasts	48.8 nTPM
Placenta	81.2 nTPM
Adipose tissue	64.3 nTPM
Stomach	56.4 nTPM
Esophagus	52.3 nTPM
Ovary	48.9 nTPM
Skeletal muscle	48.8 nTPM
Breast	45.1 nTPM
Heart muscle	42.4 nTPM
Skin	41.6 nTPM
Prostate	31.6 nTPM
Lung	24.6 nTPM

Intestinal goblet cells	59.0 nTPM
Rectum	68.5 nTPM
Colon	58.6 nTPM
Small intestine	50.0 nTPM

Macrophages	130.3 nTPM
Pancreas	370.1 nTPM
Ovary	274.4 nTPM
Lung	171.3 nTPM
Prostate	151.3 nTPM
Adipose tissue	130.7 nTPM
Testis	119.1 nTPM
Spleen	106.8 nTPM
Stomach	105.5 nTPM
Kidney	104.3 nTPM
Bone marrow	93.7 nTPM
Esophagus	88.1 nTPM
Breast	83.2 nTPM
Skeletal muscle	67.8 nTPM
Endometrium	61.2 nTPM
PBMC	27.3 nTPM

Paneth cells	67.5 nTPM
Colon	88.9 nTPM
Rectum	64.8 nTPM
Small intestine	48.8 nTPM

Plasma cells	61.7 nTPM
Stomach	94.4 nTPM
Spleen	65.6 nTPM
Esophagus	61.7 nTPM
Adipose tissue	47.1 nTPM
Bone marrow	39.5 nTPM

Respiratory ciliated cells	112.5 nTPM
Bronchus	150.6 nTPM
Lung	74.4 nTPM

Smooth muscle cells	45.5 nTPM
Pancreas	78.7 nTPM
Heart muscle	55.4 nTPM
Esophagus	52.7 nTPM
Ovary	45.2 nTPM
Adipose tissue	45.0 nTPM
Bronchus	43.1 nTPM
Skeletal muscle	40.6 nTPM
Breast	38.7 nTPM
Prostate	36.2 nTPM
Skin	35.5 nTPM
Endometrium	28.7 nTPM

Basal keratinocytes	30.2 nTPM
Skin	30.2 nTPM

Basal prostatic cells	42.7 nTPM
Prostate	42.7 nTPM

Basal respiratory cells	122.4 nTPM
Bronchus	122.4 nTPM

Basal squamous epithelial cells	25.6 nTPM
Esophagus	25.6 nTPM

T-cells	36.3 nTPM
Lung	60.7 nTPM
Stomach	47.5 nTPM
Ovary	46.7 nTPM
Kidney	43.8 nTPM
Skin	42.8 nTPM
Spleen	38.7 nTPM
Bone marrow	38.0 nTPM
Prostate	37.9 nTPM
Liver	36.1 nTPM
Lymph node	35.5 nTPM
Colon	35.1 nTPM
Adipose tissue	31.9 nTPM
Breast	30.3 nTPM
PBMC	27.1 nTPM
Skeletal muscle	27.1 nTPM
Endometrium	23.9 nTPM
Esophagus	13.1 nTPM

Undifferentiated cells	54.6 nTPM
Rectum	67.5 nTPM
Colon	59.6 nTPM
Small intestine	36.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC