Single cell type - ACADVL - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ACADVL
Gene descriptionⁱ Full gene name according to HGNC.	Acyl-CoA dehydrogenase very long chain
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Intestinal epithelial cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ACADVL is part of cluster 53 Intestinal epithelial cells - Unknown function with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
GPN2	GPN-loop GTPase 2	0.5357	53
SLC9A1	Solute carrier family 9 member A1	0.5301	53
HOOK2	Hook microtubule tethering protein 2	0.5294	45
DEDD2	Death effector domain containing 2	0.5245	53
TICAM1	Toll like receptor adaptor molecule 1	0.5223	53
ABHD11	Abhydrolase domain containing 11	0.5180	53
CLPTM1	CLPTM1 regulator of GABA type A receptor forward trafficking	0.5100	55
MED16	Mediator complex subunit 16	0.5096	53
SPINT1	Serine peptidase inhibitor, Kunitz type 1	0.5073	47
RDH13	Retinol dehydrogenase 13	0.5057	18
PKP3	Plakophilin 3	0.5036	53
ARL14	ADP ribosylation factor like GTPase 14	0.5031	53
UGT2B17	UDP glucuronosyltransferase family 2 member B17	0.5012	53
AKT1S1	AKT1 substrate 1	0.4992	53
TMEM184A	Transmembrane protein 184A	0.4989	53

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	109.9 nTPM
Breast	124.1 nTPM
Adipose tissue	95.8 nTPM

Alveolar cells type 1	60.9 nTPM
Lung	60.9 nTPM

Alveolar cells type 2	81.9 nTPM
Lung	81.9 nTPM

Astrocytes	143.3 nTPM
Brain	143.3 nTPM

B-cells	72.3 nTPM
Breast	159.2 nTPM
Liver	117.3 nTPM
Stomach	69.5 nTPM
Spleen	63.7 nTPM
Bone marrow	62.1 nTPM
Kidney	61.9 nTPM
Colon	59.1 nTPM
PBMC	47.1 nTPM
Adipose tissue	42.6 nTPM
Lymph node	40.7 nTPM

Dendritic cells	87.7 nTPM
Breast	123.2 nTPM
PBMC	71.8 nTPM
Adipose tissue	68.1 nTPM

Endothelial cells	77.4 nTPM
Prostate	183.9 nTPM
Heart muscle	109.5 nTPM
Ovary	90.8 nTPM
Breast	90.5 nTPM
Pancreas	81.1 nTPM
Skin	80.0 nTPM
Placenta	77.9 nTPM
Skeletal muscle	68.1 nTPM
Testis	66.0 nTPM
Esophagus	61.2 nTPM
Eye	51.0 nTPM
Endometrium	49.1 nTPM
Liver	45.8 nTPM
Lung	28.1 nTPM

Enteroendocrine cells	179.3 nTPM
Rectum	184.5 nTPM
Colon	174.1 nTPM

Fibroblasts	118.6 nTPM
Prostate	220.3 nTPM
Adipose tissue	144.1 nTPM
Heart muscle	131.6 nTPM
Breast	129.9 nTPM
Placenta	122.2 nTPM
Ovary	115.2 nTPM
Skin	111.6 nTPM
Lung	91.6 nTPM
Esophagus	84.3 nTPM
Skeletal muscle	78.2 nTPM
Stomach	75.7 nTPM

Intestinal goblet cells	251.8 nTPM
Colon	447.4 nTPM
Small intestine	159.1 nTPM
Rectum	148.8 nTPM

Macrophages	101.5 nTPM
Pancreas	186.4 nTPM
Prostate	168.5 nTPM
Adipose tissue	135.5 nTPM
Stomach	123.1 nTPM
Kidney	109.6 nTPM
Ovary	104.0 nTPM
Bone marrow	102.5 nTPM
Breast	100.0 nTPM
Lung	97.4 nTPM
Spleen	94.3 nTPM
Esophagus	83.4 nTPM
Skeletal muscle	68.9 nTPM
Endometrium	68.0 nTPM
Testis	53.5 nTPM
PBMC	27.3 nTPM

Paneth cells	388.9 nTPM
Colon	744.4 nTPM
Rectum	211.9 nTPM
Small intestine	210.2 nTPM

Plasma cells	172.3 nTPM
Stomach	325.1 nTPM
Spleen	171.7 nTPM
Esophagus	135.4 nTPM
Bone marrow	115.3 nTPM
Adipose tissue	114.1 nTPM

Respiratory ciliated cells	144.1 nTPM
Bronchus	269.3 nTPM
Lung	19.0 nTPM

Smooth muscle cells	147.4 nTPM
Prostate	241.3 nTPM
Ovary	196.1 nTPM
Bronchus	187.7 nTPM
Pancreas	182.2 nTPM
Breast	178.3 nTPM
Adipose tissue	166.4 nTPM
Skeletal muscle	112.7 nTPM
Skin	101.1 nTPM
Heart muscle	95.3 nTPM
Esophagus	93.1 nTPM
Endometrium	67.2 nTPM

Basal keratinocytes	87.3 nTPM
Skin	87.3 nTPM

Basal prostatic cells	336.0 nTPM
Prostate	336.0 nTPM

Basal respiratory cells	322.4 nTPM
Bronchus	322.4 nTPM

Cholangiocytes	138.7 nTPM
Liver	138.7 nTPM

T-cells	75.5 nTPM
Prostate	194.1 nTPM
Ovary	120.1 nTPM
Colon	94.6 nTPM
Kidney	93.1 nTPM
Breast	92.4 nTPM
Spleen	78.2 nTPM
Skin	76.0 nTPM
Stomach	71.6 nTPM
Bone marrow	71.3 nTPM
Adipose tissue	70.2 nTPM
Liver	60.2 nTPM
Skeletal muscle	59.2 nTPM
Lymph node	50.1 nTPM
Endometrium	49.6 nTPM
PBMC	42.9 nTPM
Lung	39.5 nTPM
Esophagus	19.7 nTPM

Undifferentiated cells	316.8 nTPM
Colon	484.1 nTPM
Small intestine	236.4 nTPM
Rectum	229.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC