Single cell type - HOOK2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HOOK2
Gene descriptionⁱ Full gene name according to HGNC.	Hook microtubule tethering protein 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Enterocytes - Digestion (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Proximal enterocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (MCF7, RT4)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Proximal enterocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

HOOK2 is part of cluster 45 Enterocytes - Digestion with confidenceⁱ 1
268 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
FUT2	Fucosyltransferase 2	0.6047	26
CNKSR1	Connector enhancer of kinase suppressor of Ras 1	0.5929	26
OAT	Ornithine aminotransferase	0.5884	45
ACADVL	Acyl-CoA dehydrogenase very long chain	0.5294	53
CD82	CD82 molecule	0.5252	26
RABGGTA	Rab geranylgeranyltransferase subunit alpha	0.5176	26
KRT19	Keratin 19	0.5116	26
ZC3H12A	Zinc finger CCCH-type containing 12A	0.5095	7
TMC4	Transmembrane channel like 4	0.5089	26
LGALS3BP	Galectin 3 binding protein	0.5056	53
ELMO3	Engulfment and cell motility 3	0.5001	53
CLDN15	Claudin 15	0.4982	45
EDN2	Endothelin 2	0.4965	26
SLC9A1	Solute carrier family 9 member A1	0.4931	53
RBP2	Retinol binding protein 2	0.4907	45

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	14.8 nTPM
Breast	18.8 nTPM
Adipose tissue	10.8 nTPM

Alveolar cells type 1	19.2 nTPM
Lung	19.2 nTPM

Alveolar cells type 2	38.0 nTPM
Lung	38.0 nTPM

Astrocytes	25.1 nTPM
Brain	25.1 nTPM

B-cells	34.4 nTPM
Lymph node	78.7 nTPM
Stomach	66.8 nTPM
Spleen	57.5 nTPM
Colon	36.7 nTPM
Breast	29.4 nTPM
Kidney	19.0 nTPM
Bone marrow	18.8 nTPM
PBMC	14.3 nTPM
Liver	13.4 nTPM
Adipose tissue	9.0 nTPM

Basal squamous epithelial cells	158.8 nTPM
Esophagus	158.8 nTPM

Dendritic cells	11.9 nTPM
Breast	25.2 nTPM
Adipose tissue	6.4 nTPM
PBMC	4.0 nTPM

Endothelial cells	18.6 nTPM
Esophagus	49.5 nTPM
Testis	27.5 nTPM
Breast	23.7 nTPM
Eye	20.3 nTPM
Prostate	19.8 nTPM
Ovary	19.1 nTPM
Skin	16.0 nTPM
Placenta	13.7 nTPM
Skeletal muscle	13.7 nTPM
Liver	12.8 nTPM
Endometrium	12.8 nTPM
Pancreas	11.6 nTPM
Heart muscle	10.7 nTPM
Lung	9.3 nTPM

Fibroblasts	24.2 nTPM
Stomach	53.4 nTPM
Esophagus	44.6 nTPM
Ovary	30.7 nTPM
Prostate	30.6 nTPM
Breast	25.3 nTPM
Placenta	25.0 nTPM
Skin	17.6 nTPM
Skeletal muscle	14.3 nTPM
Lung	10.1 nTPM
Adipose tissue	8.9 nTPM
Heart muscle	5.3 nTPM

Intestinal goblet cells	93.9 nTPM
Colon	143.7 nTPM
Small intestine	89.6 nTPM
Rectum	48.5 nTPM

Macrophages	20.4 nTPM
Esophagus	66.1 nTPM
Breast	37.7 nTPM
Spleen	32.1 nTPM
Stomach	26.4 nTPM
Bone marrow	23.7 nTPM
Prostate	21.8 nTPM
Skeletal muscle	19.6 nTPM
Testis	18.0 nTPM
Kidney	15.2 nTPM
Ovary	13.8 nTPM
Endometrium	11.6 nTPM
Adipose tissue	9.7 nTPM
Lung	7.8 nTPM
Pancreas	2.5 nTPM
PBMC	0.0 nTPM

Paneth cells	98.0 nTPM
Colon	118.6 nTPM
Small intestine	108.8 nTPM
Rectum	66.5 nTPM

Plasma cells	30.1 nTPM
Esophagus	67.8 nTPM
Stomach	39.2 nTPM
Spleen	16.6 nTPM
Bone marrow	16.5 nTPM
Adipose tissue	10.3 nTPM

Respiratory ciliated cells	49.3 nTPM
Bronchus	81.2 nTPM
Lung	17.5 nTPM

Smooth muscle cells	25.4 nTPM
Esophagus	85.3 nTPM
Bronchus	32.6 nTPM
Ovary	25.8 nTPM
Breast	23.3 nTPM
Skin	22.7 nTPM
Endometrium	20.3 nTPM
Skeletal muscle	19.6 nTPM
Prostate	18.7 nTPM
Pancreas	13.2 nTPM
Adipose tissue	11.0 nTPM
Heart muscle	7.0 nTPM

Cholangiocytes	75.8 nTPM
Liver	75.8 nTPM

Collecting duct cells	82.8 nTPM
Kidney	82.8 nTPM

Cone photoreceptor cells	100.1 nTPM
Eye	100.1 nTPM

Cytotrophoblasts	85.0 nTPM
Placenta	85.0 nTPM

T-cells	27.9 nTPM
Lymph node	88.7 nTPM
Spleen	69.8 nTPM
Stomach	38.4 nTPM
Breast	36.5 nTPM
Prostate	33.1 nTPM
Skin	30.4 nTPM
Esophagus	26.2 nTPM
PBMC	20.5 nTPM
Colon	20.0 nTPM
Kidney	19.1 nTPM
Lung	16.7 nTPM
Bone marrow	16.2 nTPM
Skeletal muscle	14.4 nTPM
Liver	13.5 nTPM
Endometrium	12.5 nTPM
Adipose tissue	9.8 nTPM
Ovary	8.9 nTPM

Undifferentiated cells	95.6 nTPM
Colon	130.3 nTPM
Small intestine	87.2 nTPM
Rectum	69.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC