Single cell type - NDE1 - The Human Protein Atlas

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NDE1

SUMMARY

TISSUE

BRAIN

SINGLE CELL

TISSUE CELL

PATHOLOGY

IMMUNE

BLOOD

SUBCELL

CELL LINE

METABOLIC

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NDE1
Gene descriptionⁱ Full gene name according to HGNC.	NudE neurodevelopment protein 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	11

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	NK-cells & T-cells - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Oligodendrocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Oligodendrocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

NDE1 is part of cluster 63 NK-cells & T-cells - Immune response with confidenceⁱ 1
362 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PHF11	PHD finger protein 11	0.4691	63
NCAPD2	Non-SMC condensin I complex subunit D2	0.4537	12
DDB2	Damage specific DNA binding protein 2	0.4430	3
ASCC2	Activating signal cointegrator 1 complex subunit 2	0.4196	34
CCR9	C-C motif chemokine receptor 9	0.4194	58
ALKBH6	AlkB homolog 6	0.4131	58
GRK6	G protein-coupled receptor kinase 6	0.4118	55
ARHGAP11B	Rho GTPase activating protein 11B	0.4108	12
TRIM59	Tripartite motif containing 59	0.4106	42
DEFA4	Defensin alpha 4	0.4018	58
SIT1	Signaling threshold regulating transmembrane adaptor 1	0.3978	63
GCSAM	Germinal center associated signaling and motility	0.3975	3
SUN2	Sad1 and UNC84 domain containing 2	0.3945	63
GATA1	GATA binding protein 1	0.3867	6
DENND2D	DENN domain containing 2D	0.3862	63

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	11.7 nTPM
Breast	12.2 nTPM
Adipose tissue	11.1 nTPM

Alveolar cells type 1	3.2 nTPM
Lung	3.2 nTPM

Alveolar cells type 2	4.4 nTPM
Lung	4.4 nTPM

Astrocytes	11.1 nTPM
Brain	11.1 nTPM

B-cells	36.1 nTPM
PBMC	64.2 nTPM
Lymph node	45.2 nTPM
Spleen	45.0 nTPM
Bone marrow	44.2 nTPM
Stomach	39.5 nTPM
Colon	35.1 nTPM
Adipose tissue	31.1 nTPM
Kidney	23.8 nTPM
Breast	21.3 nTPM
Liver	11.8 nTPM

Basal keratinocytes	26.0 nTPM
Skin	26.0 nTPM

Basal prostatic cells	32.7 nTPM
Prostate	32.7 nTPM

Basal respiratory cells	19.0 nTPM
Bronchus	19.0 nTPM

Basal squamous epithelial cells	24.5 nTPM
Esophagus	24.5 nTPM

Bipolar cells	7.0 nTPM
Eye	7.0 nTPM

Breast glandular cells	9.5 nTPM
Breast	9.5 nTPM

Breast myoepithelial cells	10.4 nTPM
Breast	10.4 nTPM

Cardiomyocytes	2.0 nTPM
Heart muscle	2.0 nTPM

Cholangiocytes	4.3 nTPM
Liver	4.3 nTPM

Club cells	8.9 nTPM
Bronchus	11.6 nTPM
Lung	6.2 nTPM

Collecting duct cells	5.5 nTPM
Kidney	5.5 nTPM

Cone photoreceptor cells	6.2 nTPM
Eye	6.2 nTPM

Cytotrophoblasts	3.9 nTPM
Placenta	3.9 nTPM

Dendritic cells	25.0 nTPM
Adipose tissue	30.3 nTPM
Breast	28.8 nTPM
PBMC	16.0 nTPM

Distal enterocytes	9.6 nTPM
Colon	15.5 nTPM
Rectum	3.8 nTPM

Distal tubular cells	0.0 nTPM
Kidney	0.0 nTPM

Ductal cells	4.5 nTPM
Pancreas	4.5 nTPM

Early spermatids	46.9 nTPM
Testis	46.9 nTPM

Endometrial ciliated cells	17.1 nTPM
Endometrium	17.1 nTPM

Endometrial stromal cells	23.1 nTPM
Endometrium	23.1 nTPM

Endothelial cells	11.6 nTPM
Eye	23.5 nTPM
Endometrium	19.2 nTPM
Ovary	19.0 nTPM
Skeletal muscle	16.7 nTPM
Esophagus	16.4 nTPM
Placenta	13.1 nTPM
Prostate	11.6 nTPM
Breast	10.4 nTPM
Testis	8.9 nTPM
Liver	8.2 nTPM
Skin	8.2 nTPM
Heart muscle	3.6 nTPM
Lung	3.1 nTPM
Pancreas	0.0 nTPM

Enteroendocrine cells	4.2 nTPM
Rectum	4.8 nTPM
Colon	3.6 nTPM

Erythroid cells	49.0 nTPM
Liver	69.5 nTPM
Bone marrow	28.6 nTPM

Excitatory neurons	2.1 nTPM
Brain	2.1 nTPM

Exocrine glandular cells	5.3 nTPM
Pancreas	5.3 nTPM

Extravillous trophoblasts	5.3 nTPM
Placenta	5.3 nTPM

Fibroblasts	11.8 nTPM
Esophagus	20.8 nTPM
Stomach	19.3 nTPM
Ovary	13.7 nTPM
Adipose tissue	13.1 nTPM
Skeletal muscle	12.7 nTPM
Prostate	11.0 nTPM
Skin	10.5 nTPM
Breast	10.5 nTPM
Placenta	9.1 nTPM
Lung	6.7 nTPM
Heart muscle	2.7 nTPM

Gastric mucus-secreting cells	19.4 nTPM
Stomach	19.4 nTPM

Glandular and luminal cells	15.0 nTPM
Endometrium	15.0 nTPM

Granulocytes	10.8 nTPM
Lung	12.6 nTPM
Colon	8.9 nTPM

Granulosa cells	15.5 nTPM
Ovary	15.5 nTPM

Hepatic stellate cells	8.6 nTPM
Liver	8.6 nTPM

Hepatocytes	1.7 nTPM
Liver	1.7 nTPM

Hofbauer cells	10.1 nTPM
Placenta	10.1 nTPM

Horizontal cells	3.3 nTPM
Eye	3.3 nTPM

Inhibitory neurons	2.4 nTPM
Brain	2.4 nTPM

Intestinal goblet cells	7.4 nTPM
Colon	10.0 nTPM
Small intestine	6.2 nTPM
Rectum	5.9 nTPM

Ionocytes	2.0 nTPM
Bronchus	2.0 nTPM

Kupffer cells	15.8 nTPM
Liver	15.8 nTPM

Langerhans cells	11.0 nTPM
Skin	11.0 nTPM

Late spermatids	58.5 nTPM
Testis	58.5 nTPM

Leydig cells	15.8 nTPM
Testis	15.8 nTPM

Macrophages	19.3 nTPM
Endometrium	38.2 nTPM
Breast	30.5 nTPM
Testis	26.7 nTPM
Stomach	26.4 nTPM
Adipose tissue	24.2 nTPM
Prostate	24.1 nTPM
Esophagus	22.0 nTPM
Spleen	18.6 nTPM
Skeletal muscle	17.6 nTPM
Bone marrow	15.0 nTPM
Kidney	13.7 nTPM
Ovary	13.7 nTPM
Pancreas	10.2 nTPM
Lung	8.6 nTPM
PBMC	0.0 nTPM

Melanocytes	12.4 nTPM
Skin	12.4 nTPM

Microglial cells	22.5 nTPM
Brain	22.5 nTPM

Monocytes	53.0 nTPM
Pancreas	73.3 nTPM
PBMC	32.7 nTPM

Muller glia cells	7.4 nTPM
Eye	7.4 nTPM

Nk-cells	50.4 nTPM
PBMC	50.4 nTPM

Oligodendrocyte precursor cells	9.5 nTPM
Brain	9.5 nTPM

Oligodendrocytes	105.5 nTPM
Brain	105.5 nTPM

Pancreatic endocrine cells	7.1 nTPM
Pancreas	7.1 nTPM

Paneth cells	4.2 nTPM
Colon	6.5 nTPM
Rectum	6.1 nTPM
Small intestine	0.0 nTPM

Peritubular cells	6.0 nTPM
Testis	6.0 nTPM

Plasma cells	16.6 nTPM
Spleen	28.3 nTPM
Bone marrow	19.8 nTPM
Adipose tissue	19.4 nTPM
Stomach	9.1 nTPM
Esophagus	6.1 nTPM

Prostatic glandular cells	26.3 nTPM
Prostate	26.3 nTPM

Proximal enterocytes	4.6 nTPM
Small intestine	4.6 nTPM

Proximal tubular cells	1.9 nTPM
Kidney	1.9 nTPM

Respiratory ciliated cells	13.3 nTPM
Bronchus	13.5 nTPM
Lung	13.1 nTPM

Rod photoreceptor cells	6.5 nTPM
Eye	6.5 nTPM

Sertoli cells	6.6 nTPM
Testis	6.6 nTPM

Skeletal myocytes	6.9 nTPM
Skeletal muscle	6.9 nTPM

Smooth muscle cells	9.5 nTPM
Endometrium	19.6 nTPM
Esophagus	18.6 nTPM
Breast	10.7 nTPM
Prostate	10.1 nTPM
Ovary	10.0 nTPM
Skeletal muscle	8.4 nTPM
Adipose tissue	7.9 nTPM
Heart muscle	7.4 nTPM
Pancreas	7.0 nTPM
Skin	3.5 nTPM
Bronchus	1.8 nTPM

Spermatocytes	13.8 nTPM
Testis	13.8 nTPM

Spermatogonia	10.0 nTPM
Testis	10.0 nTPM

Squamous epithelial cells	18.8 nTPM
Esophagus	18.8 nTPM

Suprabasal keratinocytes	30.7 nTPM
Skin	30.7 nTPM

Syncytiotrophoblasts	2.5 nTPM
Placenta	2.5 nTPM

T-cells	28.3 nTPM
PBMC	50.0 nTPM
Spleen	43.2 nTPM
Bone marrow	42.3 nTPM
Lymph node	40.3 nTPM
Endometrium	30.9 nTPM
Liver	30.1 nTPM
Adipose tissue	28.8 nTPM
Breast	27.8 nTPM
Stomach	27.0 nTPM
Kidney	26.7 nTPM
Ovary	24.5 nTPM
Skeletal muscle	24.4 nTPM
Colon	21.4 nTPM
Esophagus	19.7 nTPM
Skin	18.0 nTPM
Lung	16.7 nTPM
Prostate	9.5 nTPM

Theca cells	9.8 nTPM
Ovary	9.8 nTPM

Undifferentiated cells	10.2 nTPM
Colon	12.9 nTPM
Small intestine	9.4 nTPM
Rectum	8.2 nTPM

Urothelial cells	21.6 nTPM
Prostate	21.6 nTPM

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.