Single cell type - ASCC2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ASCC2
Gene descriptionⁱ Full gene name according to HGNC.	Activating signal cointegrator 1 complex subunit 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatids - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ASCC2 is part of cluster 34 Spermatids - Unknown function with confidenceⁱ 1
366 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
HEMGN	Hemogen	0.7644	6
HARBI1	Harbinger transposase derived 1	0.6864	34
SLC25A37	Solute carrier family 25 member 37	0.6513	6
NATD1	N-acetyltransferase domain containing 1	0.6338	6
ISCA1	Iron-sulfur cluster assembly 1	0.6293	34
TUBG1	Tubulin gamma 1	0.6073	34
FAM104A	Family with sequence similarity 104 member A	0.5808	34
CARD18	Caspase recruitment domain family member 18	0.5652	34
ACP1	Acid phosphatase 1	0.5639	34
TEX35	Testis expressed 35	0.5468	34
E2F4	E2F transcription factor 4	0.5417	6
FBXO39	F-box protein 39	0.5389	34
SIRPD	Signal regulatory protein delta	0.5386	34
FHL5	Four and a half LIM domains 5	0.5378	34
OR11A1	Olfactory receptor family 11 subfamily A member 1	0.5356	34

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	27.7 nTPM
Adipose tissue	29.3 nTPM
Breast	26.1 nTPM

Alveolar cells type 1	19.2 nTPM
Lung	19.2 nTPM

Alveolar cells type 2	14.7 nTPM
Lung	14.7 nTPM

Astrocytes	18.6 nTPM
Brain	18.6 nTPM

B-cells	35.8 nTPM
PBMC	67.1 nTPM
Stomach	43.6 nTPM
Bone marrow	38.5 nTPM
Liver	37.3 nTPM
Spleen	36.0 nTPM
Lymph node	35.7 nTPM
Colon	25.5 nTPM
Adipose tissue	25.5 nTPM
Breast	25.5 nTPM
Kidney	23.8 nTPM

Dendritic cells	40.5 nTPM
PBMC	55.8 nTPM
Adipose tissue	37.9 nTPM
Breast	27.7 nTPM

Endothelial cells	20.7 nTPM
Pancreas	30.9 nTPM
Heart muscle	25.9 nTPM
Ovary	25.6 nTPM
Skeletal muscle	24.2 nTPM
Skin	23.9 nTPM
Placenta	22.1 nTPM
Liver	22.0 nTPM
Testis	21.4 nTPM
Breast	21.4 nTPM
Esophagus	20.6 nTPM
Prostate	17.8 nTPM
Endometrium	16.9 nTPM
Eye	11.3 nTPM
Lung	6.2 nTPM

Erythroid cells	116.0 nTPM
Liver	203.4 nTPM
Bone marrow	28.6 nTPM

Fibroblasts	22.9 nTPM
Placenta	29.9 nTPM
Adipose tissue	29.9 nTPM
Skin	28.6 nTPM
Stomach	26.7 nTPM
Skeletal muscle	24.1 nTPM
Esophagus	23.4 nTPM
Ovary	21.5 nTPM
Heart muscle	19.1 nTPM
Lung	19.0 nTPM
Breast	18.4 nTPM
Prostate	11.7 nTPM

Intestinal goblet cells	23.2 nTPM
Colon	31.5 nTPM
Small intestine	20.8 nTPM
Rectum	17.2 nTPM

Macrophages	29.1 nTPM
Kidney	47.6 nTPM
Testis	43.0 nTPM
Pancreas	35.7 nTPM
Prostate	33.2 nTPM
Adipose tissue	32.4 nTPM
Stomach	32.2 nTPM
Breast	31.0 nTPM
Ovary	30.1 nTPM
Skeletal muscle	28.1 nTPM
Lung	26.2 nTPM
Bone marrow	26.2 nTPM
Spleen	26.0 nTPM
Endometrium	22.2 nTPM
Esophagus	22.0 nTPM
PBMC	0.0 nTPM

Paneth cells	34.0 nTPM
Colon	52.6 nTPM
Small intestine	26.3 nTPM
Rectum	23.1 nTPM

Plasma cells	32.4 nTPM
Spleen	41.6 nTPM
Stomach	40.6 nTPM
Bone marrow	28.0 nTPM
Adipose tissue	27.1 nTPM
Esophagus	24.6 nTPM

Respiratory ciliated cells	24.4 nTPM
Bronchus	28.4 nTPM
Lung	20.4 nTPM

Smooth muscle cells	19.7 nTPM
Pancreas	40.5 nTPM
Bronchus	25.4 nTPM
Ovary	20.4 nTPM
Skin	19.2 nTPM
Skeletal muscle	18.8 nTPM
Breast	17.5 nTPM
Prostate	16.2 nTPM
Heart muscle	16.1 nTPM
Esophagus	15.5 nTPM
Endometrium	14.2 nTPM
Adipose tissue	12.5 nTPM

Basal keratinocytes	30.0 nTPM
Skin	30.0 nTPM

Basal prostatic cells	25.2 nTPM
Prostate	25.2 nTPM

Basal respiratory cells	38.1 nTPM
Bronchus	38.1 nTPM

Basal squamous epithelial cells	13.1 nTPM
Esophagus	13.1 nTPM

T-cells	34.9 nTPM
PBMC	63.7 nTPM
Liver	62.3 nTPM
Stomach	47.0 nTPM
Kidney	45.2 nTPM
Bone marrow	39.2 nTPM
Lung	38.0 nTPM
Lymph node	36.3 nTPM
Colon	36.1 nTPM
Adipose tissue	34.5 nTPM
Skin	32.3 nTPM
Spleen	31.3 nTPM
Breast	27.9 nTPM
Endometrium	25.5 nTPM
Skeletal muscle	23.6 nTPM
Prostate	19.0 nTPM
Ovary	17.8 nTPM
Esophagus	13.1 nTPM

Undifferentiated cells	23.9 nTPM
Colon	29.3 nTPM
Small intestine	22.5 nTPM
Rectum	19.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC