Single cell type - PDE8A - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PDE8A
Gene descriptionⁱ Full gene name according to HGNC.	Phosphodiesterase 8A
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Oligodendrocytes - Myelin sheath organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (Oligodendrocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (RT4)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enriched (Oligodendrocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PDE8A is part of cluster 42 Oligodendrocytes - Myelin sheath organization with confidenceⁱ 1
385 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
OR9A2	Olfactory receptor family 9 subfamily A member 2	0.8471	42
SLC5A11	Solute carrier family 5 member 11	0.8300	42
SLCO1A2	Solute carrier organic anion transporter family member 1A2	0.8257	42
OPALIN	Oligodendrocytic myelin paranodal and inner loop protein	0.8235	42
MOG	Myelin oligodendrocyte glycoprotein	0.8233	42
TMEM235	Transmembrane protein 235	0.8182	42
RNF220	Ring finger protein 220	0.8132	42
TRPV5	Transient receptor potential cation channel subfamily V member 5	0.8127	42
ST18	ST18 C2H2C-type zinc finger transcription factor	0.8083	42
ERMN	Ermin	0.8080	42
CNDP1	Carnosine dipeptidase 1	0.8069	42
MAN2A1	Mannosidase alpha class 2A member 1	0.8005	42
SLC44A1	Solute carrier family 44 member 1	0.7998	42
UGT8	UDP glycosyltransferase 8	0.7995	42
GLDN	Gliomedin	0.7980	42

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	30.7 nTPM
Adipose tissue	32.0 nTPM
Breast	29.5 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	26.5 nTPM
Lung	26.5 nTPM

Astrocytes	83.9 nTPM
Brain	83.9 nTPM

B-cells	14.8 nTPM
Lymph node	25.4 nTPM
Spleen	19.7 nTPM
Stomach	19.5 nTPM
Adipose tissue	18.6 nTPM
Colon	17.6 nTPM
Breast	16.0 nTPM
PBMC	12.9 nTPM
Bone marrow	9.0 nTPM
Kidney	4.8 nTPM
Liver	4.6 nTPM

Dendritic cells	5.5 nTPM
Adipose tissue	10.4 nTPM
Breast	6.2 nTPM
PBMC	0.0 nTPM

Endothelial cells	24.3 nTPM
Ovary	55.8 nTPM
Endometrium	30.5 nTPM
Prostate	29.9 nTPM
Liver	29.3 nTPM
Esophagus	28.9 nTPM
Skeletal muscle	27.8 nTPM
Eye	21.0 nTPM
Breast	20.5 nTPM
Pancreas	19.3 nTPM
Heart muscle	19.2 nTPM
Placenta	15.9 nTPM
Skin	14.9 nTPM
Testis	14.2 nTPM
Lung	12.5 nTPM

Fibroblasts	16.2 nTPM
Prostate	21.8 nTPM
Adipose tissue	21.3 nTPM
Skeletal muscle	20.8 nTPM
Stomach	19.3 nTPM
Heart muscle	17.2 nTPM
Skin	16.1 nTPM
Breast	15.1 nTPM
Lung	14.5 nTPM
Ovary	14.2 nTPM
Esophagus	11.3 nTPM
Placenta	6.1 nTPM

Intestinal goblet cells	19.0 nTPM
Rectum	30.0 nTPM
Colon	15.7 nTPM
Small intestine	11.4 nTPM

Macrophages	19.2 nTPM
Prostate	43.5 nTPM
Spleen	41.4 nTPM
Adipose tissue	31.5 nTPM
Lung	28.2 nTPM
Bone marrow	20.0 nTPM
Skeletal muscle	18.4 nTPM
Breast	17.3 nTPM
Ovary	16.6 nTPM
Stomach	14.7 nTPM
Esophagus	12.6 nTPM
Endometrium	11.9 nTPM
Kidney	11.4 nTPM
Testis	11.1 nTPM
Pancreas	10.2 nTPM
PBMC	0.0 nTPM

Paneth cells	31.8 nTPM
Rectum	44.3 nTPM
Colon	36.2 nTPM
Small intestine	15.0 nTPM

Plasma cells	7.2 nTPM
Adipose tissue	13.0 nTPM
Stomach	7.4 nTPM
Bone marrow	6.6 nTPM
Esophagus	6.1 nTPM
Spleen	2.9 nTPM

Respiratory ciliated cells	10.5 nTPM
Lung	11.7 nTPM
Bronchus	9.3 nTPM

Smooth muscle cells	24.5 nTPM
Heart muscle	54.7 nTPM
Prostate	44.4 nTPM
Adipose tissue	44.0 nTPM
Skeletal muscle	38.1 nTPM
Ovary	18.0 nTPM
Endometrium	17.5 nTPM
Skin	14.3 nTPM
Breast	13.1 nTPM
Pancreas	12.9 nTPM
Esophagus	9.3 nTPM
Bronchus	2.9 nTPM

T-cells	10.8 nTPM
Skeletal muscle	21.6 nTPM
Lymph node	21.4 nTPM
Lung	16.7 nTPM
Adipose tissue	16.5 nTPM
Skin	15.2 nTPM
Spleen	14.1 nTPM
Esophagus	13.1 nTPM
Endometrium	10.7 nTPM
Bone marrow	9.0 nTPM
Breast	8.9 nTPM
Stomach	7.6 nTPM
PBMC	6.0 nTPM
Colon	5.2 nTPM
Liver	4.8 nTPM
Prostate	4.7 nTPM
Ovary	4.5 nTPM
Kidney	3.4 nTPM

Basal respiratory cells	13.9 nTPM
Bronchus	13.9 nTPM

Basal squamous epithelial cells	18.2 nTPM
Esophagus	18.2 nTPM

Cholangiocytes	41.5 nTPM
Liver	41.5 nTPM

Collecting duct cells	7.3 nTPM
Kidney	7.3 nTPM

Undifferentiated cells	28.5 nTPM
Rectum	43.8 nTPM
Small intestine	22.9 nTPM
Colon	18.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC