Single cell type - GLDN - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GLDN
Gene descriptionⁱ Full gene name according to HGNC.	Gliomedin
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Oligodendrocytes - Myelin sheath organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (Oligodendrocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Not detected in immune cells
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Not detected
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HHSteC, MCF7, SuSa, U-266/70, U-266/84)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enriched (Oligodendrocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

GLDN is part of cluster 42 Oligodendrocytes - Myelin sheath organization with confidenceⁱ 1
385 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PDE8A	Phosphodiesterase 8A	0.7980	42
OR9A2	Olfactory receptor family 9 subfamily A member 2	0.7900	42
TRPV5	Transient receptor potential cation channel subfamily V member 5	0.7762	42
OPALIN	Oligodendrocytic myelin paranodal and inner loop protein	0.7761	42
MOG	Myelin oligodendrocyte glycoprotein	0.7734	42
TMEM235	Transmembrane protein 235	0.7687	42
MAP6D1	MAP6 domain containing 1	0.7681	42
CARNS1	Carnosine synthase 1	0.7666	42
PLP1	Proteolipid protein 1	0.7633	42
DNAJC6	DnaJ heat shock protein family (Hsp40) member C6	0.7617	42
ERMN	Ermin	0.7609	42
SLCO1A2	Solute carrier organic anion transporter family member 1A2	0.7580	42
ST18	ST18 C2H2C-type zinc finger transcription factor	0.7573	42
MAN2A1	Mannosidase alpha class 2A member 1	0.7522	42
SLC5A11	Solute carrier family 5 member 11	0.7484	42

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	40.1 nTPM
Breast	50.7 nTPM
Adipose tissue	29.4 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	2.6 nTPM
Lung	2.6 nTPM

Astrocytes	2.0 nTPM
Brain	2.0 nTPM

B-cells	0.0 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Breast	0.0 nTPM

Dendritic cells	0.0 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM
Breast	0.0 nTPM

Endothelial cells	3.7 nTPM
Breast	17.1 nTPM
Eye	17.0 nTPM
Skin	10.0 nTPM
Skeletal muscle	4.2 nTPM
Heart muscle	1.0 nTPM
Esophagus	1.0 nTPM
Placenta	0.6 nTPM
Prostate	0.4 nTPM
Ovary	0.2 nTPM
Liver	0.0 nTPM
Lung	0.0 nTPM
Testis	0.0 nTPM
Pancreas	0.0 nTPM
Endometrium	0.0 nTPM

Fibroblasts	7.9 nTPM
Skin	71.6 nTPM
Prostate	9.3 nTPM
Adipose tissue	1.6 nTPM
Breast	1.1 nTPM
Placenta	1.0 nTPM
Skeletal muscle	0.7 nTPM
Esophagus	0.6 nTPM
Heart muscle	0.5 nTPM
Lung	0.0 nTPM
Ovary	0.0 nTPM
Stomach	0.0 nTPM

Intestinal goblet cells	1.7 nTPM
Rectum	4.4 nTPM
Colon	0.7 nTPM
Small intestine	0.0 nTPM

Macrophages	16.1 nTPM
Ovary	117.8 nTPM
Testis	41.8 nTPM
Lung	36.9 nTPM
Prostate	26.3 nTPM
Esophagus	11.0 nTPM
Adipose tissue	3.0 nTPM
Breast	2.2 nTPM
Kidney	1.5 nTPM
Skeletal muscle	1.1 nTPM
Endometrium	0.4 nTPM
PBMC	0.0 nTPM
Pancreas	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	28.6 nTPM
Colon	52.6 nTPM
Rectum	33.1 nTPM
Small intestine	0.0 nTPM

Plasma cells	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Respiratory ciliated cells	0.9 nTPM
Lung	1.5 nTPM
Bronchus	0.4 nTPM

Smooth muscle cells	9.8 nTPM
Skin	34.9 nTPM
Breast	32.0 nTPM
Adipose tissue	16.3 nTPM
Esophagus	6.2 nTPM
Skeletal muscle	5.8 nTPM
Heart muscle	4.8 nTPM
Prostate	4.1 nTPM
Ovary	3.9 nTPM
Endometrium	0.2 nTPM
Pancreas	0.0 nTPM
Bronchus	0.0 nTPM

T-cells	0.6 nTPM
Skin	9.2 nTPM
Colon	0.5 nTPM
Breast	0.3 nTPM
Endometrium	0.2 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
PBMC	0.0 nTPM
Skeletal muscle	0.0 nTPM
Ovary	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Cytotrophoblasts	5.2 nTPM
Placenta	5.2 nTPM

Distal enterocytes	47.0 nTPM
Rectum	74.0 nTPM
Colon	20.0 nTPM

Endometrial stromal cells	0.1 nTPM
Endometrium	0.1 nTPM

Excitatory neurons	7.4 nTPM
Brain	7.4 nTPM

Undifferentiated cells	5.1 nTPM
Rectum	12.9 nTPM
Colon	2.3 nTPM
Small intestine	0.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC