Single cell type - TEAD2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TEAD2
Gene descriptionⁱ Full gene name according to HGNC.	TEA domain transcription factor 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Pancreatic cells - Digestion (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Early spermatids, Ductal cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (naive B-cell, memory B-cell)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (AF22, AN3-CA)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Early spermatids, Ductal cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TEAD2 is part of cluster 1 Pancreatic cells - Digestion with confidenceⁱ 1
148 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TUBB6	Tubulin beta 6 class V	0.5720	38
TRIM47	Tripartite motif containing 47	0.5384	1
TNFAIP1	TNF alpha induced protein 1	0.5279	1
SPRR5	Small proline rich protein 5	0.5177	1
CD151	CD151 molecule (Raph blood group)	0.5121	1
CCDC192	Coiled-coil domain containing 192	0.5100	1
CCL2	C-C motif chemokine ligand 2	0.5084	48
GPRC5B	G protein-coupled receptor class C group 5 member B	0.5051	34
TAGLN	Transgelin	0.5020	48
IAPP	Islet amyloid polypeptide	0.4854	23
CSRP1	Cysteine and glycine rich protein 1	0.4839	48
MFSD6L	Major facilitator superfamily domain containing 6 like	0.4807	66
ZNF263	Zinc finger protein 263	0.4801	23
REG3A	Regenerating family member 3 alpha	0.4800	1
CDC42EP1	CDC42 effector protein 1	0.4771	1

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	26.1 nTPM
Adipose tissue	31.6 nTPM
Breast	20.6 nTPM

Alveolar cells type 1	3.2 nTPM
Lung	3.2 nTPM

Alveolar cells type 2	3.2 nTPM
Lung	3.2 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	3.8 nTPM
Bone marrow	15.5 nTPM
Lymph node	6.5 nTPM
Colon	4.8 nTPM
Stomach	4.1 nTPM
Spleen	3.1 nTPM
PBMC	2.8 nTPM
Adipose tissue	1.0 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
Breast	0.0 nTPM

Dendritic cells	0.4 nTPM
Breast	1.1 nTPM
Adipose tissue	0.1 nTPM
PBMC	0.0 nTPM

Endothelial cells	29.5 nTPM
Pancreas	54.0 nTPM
Liver	42.2 nTPM
Placenta	40.9 nTPM
Prostate	36.6 nTPM
Esophagus	36.6 nTPM
Skeletal muscle	34.5 nTPM
Testis	34.0 nTPM
Skin	28.2 nTPM
Breast	27.0 nTPM
Ovary	26.9 nTPM
Endometrium	26.0 nTPM
Lung	15.6 nTPM
Eye	8.9 nTPM
Heart muscle	1.5 nTPM

Fibroblasts	15.0 nTPM
Ovary	26.0 nTPM
Placenta	21.8 nTPM
Stomach	20.8 nTPM
Breast	18.4 nTPM
Prostate	18.2 nTPM
Esophagus	18.1 nTPM
Adipose tissue	14.6 nTPM
Skin	14.2 nTPM
Skeletal muscle	11.3 nTPM
Lung	1.2 nTPM
Heart muscle	1.1 nTPM

Intestinal goblet cells	6.6 nTPM
Rectum	11.5 nTPM
Colon	5.0 nTPM
Small intestine	3.2 nTPM

Macrophages	0.7 nTPM
Endometrium	2.4 nTPM
Testis	2.3 nTPM
Skeletal muscle	1.9 nTPM
Prostate	1.2 nTPM
Ovary	0.9 nTPM
Breast	0.7 nTPM
Lung	0.4 nTPM
Adipose tissue	0.2 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Pancreas	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	4.9 nTPM
Rectum	11.1 nTPM
Small intestine	3.7 nTPM
Colon	0.0 nTPM

Plasma cells	0.1 nTPM
Adipose tissue	0.6 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Respiratory ciliated cells	1.2 nTPM
Lung	1.5 nTPM
Bronchus	1.0 nTPM

Smooth muscle cells	28.7 nTPM
Ovary	47.6 nTPM
Skeletal muscle	45.8 nTPM
Esophagus	41.9 nTPM
Prostate	33.8 nTPM
Endometrium	32.5 nTPM
Pancreas	32.4 nTPM
Adipose tissue	28.2 nTPM
Skin	25.5 nTPM
Breast	24.1 nTPM
Heart muscle	1.8 nTPM
Bronchus	1.8 nTPM

T-cells	0.5 nTPM
Endometrium	3.3 nTPM
Liver	1.1 nTPM
Breast	1.1 nTPM
Skin	0.9 nTPM
Skeletal muscle	0.5 nTPM
Lymph node	0.4 nTPM
Bone marrow	0.4 nTPM
Spleen	0.2 nTPM
PBMC	0.1 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Ovary	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Stomach	0.0 nTPM

Basal prostatic cells	6.9 nTPM
Prostate	6.9 nTPM

Basal respiratory cells	5.9 nTPM
Bronchus	5.9 nTPM

Basal squamous epithelial cells	8.6 nTPM
Esophagus	8.6 nTPM

Cholangiocytes	8.6 nTPM
Liver	8.6 nTPM

Undifferentiated cells	6.8 nTPM
Rectum	10.3 nTPM
Small intestine	5.8 nTPM
Colon	4.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC