Single cell type - CSRP1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CSRP1
Gene descriptionⁱ Full gene name according to HGNC.	Cysteine and glycine rich protein 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Smooth muscle cells - ECM organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Breast myoepithelial cells, Smooth muscle cells, Extravillous trophoblasts, Basal prostatic cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Breast myoepithelial cells, Smooth muscle cells, Extravillous trophoblasts, Basal prostatic cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CSRP1 is part of cluster 48 Smooth muscle cells - ECM organization with confidenceⁱ 1
270 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TAGLN	Transgelin	0.7902	48
RERGL	RERG like	0.7158	48
FOXL1	Forkhead box L1	0.7092	48
CALD1	Caldesmon 1	0.7083	48
MYL9	Myosin light chain 9	0.7021	48
GPR20	G protein-coupled receptor 20	0.6929	48
SMTN	Smoothelin	0.6899	48
GJA4	Gap junction protein alpha 4	0.6785	48
MYLK	Myosin light chain kinase	0.6756	48
RGS5	Regulator of G protein signaling 5	0.6750	48
NDUFA4L2	NDUFA4 mitochondrial complex associated like 2	0.6742	48
MCAM	Melanoma cell adhesion molecule	0.6722	48
FOXC2	Forkhead box C2	0.6721	48
COX4I2	Cytochrome c oxidase subunit 4I2	0.6700	48
REM1	RRAD and GEM like GTPase 1	0.6640	48

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	151.8 nTPM
Breast	190.1 nTPM
Adipose tissue	113.6 nTPM

Alveolar cells type 1	38.5 nTPM
Lung	38.5 nTPM

Alveolar cells type 2	47.8 nTPM
Lung	47.8 nTPM

Astrocytes	86.5 nTPM
Brain	86.5 nTPM

B-cells	21.8 nTPM
Liver	58.9 nTPM
Breast	48.1 nTPM
Stomach	19.1 nTPM
PBMC	17.1 nTPM
Spleen	14.2 nTPM
Lymph node	14.0 nTPM
Bone marrow	13.1 nTPM
Adipose tissue	13.0 nTPM
Colon	11.2 nTPM
Kidney	9.5 nTPM

Basal squamous epithelial cells	207.7 nTPM
Esophagus	207.7 nTPM

Dendritic cells	23.3 nTPM
Breast	40.9 nTPM
Adipose tissue	21.0 nTPM
PBMC	8.0 nTPM

Endothelial cells	86.9 nTPM
Ovary	218.6 nTPM
Pancreas	139.0 nTPM
Placenta	114.2 nTPM
Endometrium	103.3 nTPM
Liver	102.8 nTPM
Breast	98.0 nTPM
Skeletal muscle	87.8 nTPM
Testis	87.7 nTPM
Esophagus	82.6 nTPM
Heart muscle	62.9 nTPM
Skin	58.0 nTPM
Prostate	33.0 nTPM
Lung	18.7 nTPM
Eye	10.5 nTPM

Fibroblasts	86.7 nTPM
Stomach	144.0 nTPM
Prostate	138.0 nTPM
Breast	109.4 nTPM
Lung	89.4 nTPM
Ovary	79.2 nTPM
Adipose tissue	73.6 nTPM
Esophagus	70.8 nTPM
Placenta	68.8 nTPM
Heart muscle	64.3 nTPM
Skin	61.5 nTPM
Skeletal muscle	54.8 nTPM

Intestinal goblet cells	80.0 nTPM
Colon	125.0 nTPM
Small intestine	58.9 nTPM
Rectum	56.1 nTPM

Macrophages	37.0 nTPM
Pancreas	94.4 nTPM
Breast	57.3 nTPM
Prostate	53.9 nTPM
Endometrium	44.4 nTPM
Lung	35.8 nTPM
Stomach	35.1 nTPM
Kidney	34.8 nTPM
Testis	33.7 nTPM
Adipose tissue	29.5 nTPM
Esophagus	28.3 nTPM
Skeletal muscle	27.8 nTPM
Ovary	26.4 nTPM
Bone marrow	25.0 nTPM
Spleen	14.5 nTPM
PBMC	13.6 nTPM

Paneth cells	71.4 nTPM
Colon	85.7 nTPM
Small intestine	67.5 nTPM
Rectum	61.0 nTPM

Plasma cells	61.5 nTPM
Spleen	105.6 nTPM
Bone marrow	85.7 nTPM
Stomach	68.4 nTPM
Esophagus	24.6 nTPM
Adipose tissue	23.3 nTPM

Respiratory ciliated cells	25.2 nTPM
Lung	37.9 nTPM
Bronchus	12.5 nTPM

Smooth muscle cells	419.9 nTPM
Breast	1132.5 nTPM
Esophagus	672.9 nTPM
Pancreas	509.9 nTPM
Skin	490.0 nTPM
Prostate	414.8 nTPM
Adipose tissue	377.2 nTPM
Skeletal muscle	314.0 nTPM
Heart muscle	308.7 nTPM
Ovary	211.0 nTPM
Endometrium	180.6 nTPM
Bronchus	7.5 nTPM

Cholangiocytes	21.5 nTPM
Liver	21.5 nTPM

Cone photoreceptor cells	0.0 nTPM
Eye	0.0 nTPM

Cytotrophoblasts	88.8 nTPM
Placenta	88.8 nTPM

Distal enterocytes	96.6 nTPM
Colon	110.9 nTPM
Rectum	82.3 nTPM

T-cells	31.2 nTPM
Breast	51.4 nTPM
Ovary	48.9 nTPM
Skin	48.8 nTPM
Prostate	47.3 nTPM
Stomach	35.5 nTPM
Colon	32.8 nTPM
Bone marrow	31.8 nTPM
Adipose tissue	30.9 nTPM
Esophagus	26.2 nTPM
Lung	25.8 nTPM
Spleen	25.2 nTPM
Liver	24.1 nTPM
Endometrium	23.2 nTPM
Skeletal muscle	22.6 nTPM
PBMC	21.3 nTPM
Lymph node	18.6 nTPM
Kidney	16.4 nTPM

Undifferentiated cells	69.7 nTPM
Colon	99.5 nTPM
Rectum	57.7 nTPM
Small intestine	51.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC