Single cell type - BCS1L - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	BCS1L
Gene descriptionⁱ Full gene name according to HGNC.	BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	15

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

BCS1L is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 1
586 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
COQ3	Coenzyme Q3, methyltransferase	0.5871	39
CDC123	Cell division cycle 123	0.5613	26
TRUB2	TruB pseudouridine synthase family member 2	0.5465	39
MRPS26	Mitochondrial ribosomal protein S26	0.5441	39
MRPS18B	Mitochondrial ribosomal protein S18B	0.5347	39
SSBP1	Single stranded DNA binding protein 1	0.5301	26
POLR3K	RNA polymerase III subunit K	0.5290	39
NDUFA10	NADH:ubiquinone oxidoreductase subunit A10	0.5184	39
TRIAP1	TP53 regulated inhibitor of apoptosis 1	0.5069	47
MRPL4	Mitochondrial ribosomal protein L4	0.5056	39
MRPL32	Mitochondrial ribosomal protein L32	0.4934	39
MRPL16	Mitochondrial ribosomal protein L16	0.4874	39
STOML2	Stomatin like 2	0.4828	39
UQCRC2	Ubiquinol-cytochrome c reductase core protein 2	0.4814	39
C16orf91	Chromosome 16 open reading frame 91	0.4725	39

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	16.0 nTPM
Breast	19.5 nTPM
Adipose tissue	12.5 nTPM

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	7.5 nTPM
Lung	7.5 nTPM

Astrocytes	6.5 nTPM
Brain	6.5 nTPM

B-cells	6.4 nTPM
Liver	14.3 nTPM
Spleen	8.3 nTPM
Adipose tissue	7.0 nTPM
Bone marrow	6.6 nTPM
Stomach	5.0 nTPM
Colon	4.8 nTPM
Kidney	4.8 nTPM
Lymph node	4.6 nTPM
PBMC	4.3 nTPM
Breast	4.0 nTPM

Dendritic cells	5.4 nTPM
Breast	9.9 nTPM
Adipose tissue	6.4 nTPM
PBMC	0.0 nTPM

Endothelial cells	13.7 nTPM
Placenta	19.9 nTPM
Pancreas	19.3 nTPM
Heart muscle	17.5 nTPM
Breast	17.2 nTPM
Skin	13.4 nTPM
Testis	13.0 nTPM
Eye	12.9 nTPM
Ovary	12.9 nTPM
Esophagus	12.8 nTPM
Lung	12.5 nTPM
Skeletal muscle	12.4 nTPM
Endometrium	11.8 nTPM
Prostate	9.4 nTPM
Liver	7.3 nTPM

Fibroblasts	13.8 nTPM
Heart muscle	27.6 nTPM
Placenta	20.0 nTPM
Ovary	18.7 nTPM
Breast	15.1 nTPM
Adipose tissue	12.6 nTPM
Skin	12.1 nTPM
Esophagus	11.6 nTPM
Skeletal muscle	11.1 nTPM
Lung	8.9 nTPM
Prostate	8.2 nTPM
Stomach	6.0 nTPM

Intestinal goblet cells	11.0 nTPM
Colon	16.5 nTPM
Rectum	10.3 nTPM
Small intestine	6.1 nTPM

Macrophages	6.6 nTPM
PBMC	13.6 nTPM
Breast	11.2 nTPM
Prostate	10.3 nTPM
Ovary	9.7 nTPM
Esophagus	7.9 nTPM
Testis	7.5 nTPM
Endometrium	6.2 nTPM
Adipose tissue	6.0 nTPM
Stomach	5.9 nTPM
Lung	5.2 nTPM
Pancreas	5.1 nTPM
Skeletal muscle	4.7 nTPM
Kidney	3.8 nTPM
Bone marrow	1.2 nTPM
Spleen	1.0 nTPM

Paneth cells	12.7 nTPM
Rectum	19.9 nTPM
Small intestine	15.0 nTPM
Colon	3.3 nTPM

Plasma cells	9.8 nTPM
Bone marrow	18.2 nTPM
Spleen	12.0 nTPM
Stomach	8.3 nTPM
Esophagus	6.1 nTPM
Adipose tissue	4.5 nTPM

Respiratory ciliated cells	10.7 nTPM
Bronchus	12.6 nTPM
Lung	8.7 nTPM

Smooth muscle cells	19.4 nTPM
Pancreas	32.4 nTPM
Heart muscle	29.8 nTPM
Bronchus	25.4 nTPM
Breast	22.7 nTPM
Skin	22.3 nTPM
Prostate	14.4 nTPM
Adipose tissue	14.3 nTPM
Esophagus	14.0 nTPM
Ovary	13.8 nTPM
Endometrium	13.7 nTPM
Skeletal muscle	11.1 nTPM

T-cells	6.4 nTPM
Lung	12.2 nTPM
Breast	10.0 nTPM
Endometrium	8.9 nTPM
Liver	8.7 nTPM
PBMC	8.6 nTPM
Kidney	7.5 nTPM
Bone marrow	7.5 nTPM
Colon	7.1 nTPM
Skin	6.9 nTPM
Esophagus	6.6 nTPM
Stomach	6.2 nTPM
Adipose tissue	5.7 nTPM
Ovary	4.5 nTPM
Lymph node	4.1 nTPM
Spleen	2.9 nTPM
Skeletal muscle	2.3 nTPM
Prostate	0.0 nTPM

Basal keratinocytes	10.6 nTPM
Skin	10.6 nTPM

Basal prostatic cells	15.2 nTPM
Prostate	15.2 nTPM

Basal respiratory cells	29.9 nTPM
Bronchus	29.9 nTPM

Collecting duct cells	5.5 nTPM
Kidney	5.5 nTPM

Undifferentiated cells	17.0 nTPM
Colon	18.0 nTPM
Rectum	18.0 nTPM
Small intestine	15.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC