Single cell type - UQCRC2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	UQCRC2
Gene descriptionⁱ Full gene name according to HGNC.	Ubiquinol-cytochrome c reductase core protein 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cardiomyocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cardiomyocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

UQCRC2 is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 1
586 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
NDUFA10	NADH:ubiquinone oxidoreductase subunit A10	0.7868	39
MDH2	Malate dehydrogenase 2	0.7348	39
NDUFB5	NADH:ubiquinone oxidoreductase subunit B5	0.7225	39
UQCRH	Ubiquinol-cytochrome c reductase hinge protein	0.7069	39
UQCRFS1	Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1	0.6716	39
SDHA	Succinate dehydrogenase complex flavoprotein subunit A	0.6589	39
COX7B	Cytochrome c oxidase subunit 7B	0.6400	39
COQ9	Coenzyme Q9	0.6398	39
MRPS18B	Mitochondrial ribosomal protein S18B	0.6202	39
MRPS33	Mitochondrial ribosomal protein S33	0.6123	39
DLD	Dihydrolipoamide dehydrogenase	0.6121	39
IDH3B	Isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta	0.6056	39
COX5B	Cytochrome c oxidase subunit 5B	0.5912	39
DECR1	2,4-dienoyl-CoA reductase 1	0.5835	39
SLC25A6	Solute carrier family 25 member 6	0.5748	32

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	105.5 nTPM
Adipose tissue	115.5 nTPM
Breast	95.5 nTPM

Alveolar cells type 1	64.1 nTPM
Lung	64.1 nTPM

Alveolar cells type 2	52.5 nTPM
Lung	52.5 nTPM

Astrocytes	81.9 nTPM
Brain	81.9 nTPM

B-cells	81.1 nTPM
Liver	136.1 nTPM
PBMC	117.1 nTPM
Kidney	114.3 nTPM
Colon	95.8 nTPM
Spleen	74.8 nTPM
Adipose tissue	66.7 nTPM
Bone marrow	53.2 nTPM
Stomach	52.6 nTPM
Lymph node	51.8 nTPM
Breast	48.1 nTPM

Dendritic cells	82.6 nTPM
PBMC	87.6 nTPM
Breast	82.0 nTPM
Adipose tissue	78.3 nTPM

Endothelial cells	91.3 nTPM
Pancreas	131.3 nTPM
Skeletal muscle	121.7 nTPM
Placenta	117.1 nTPM
Testis	115.2 nTPM
Breast	106.1 nTPM
Prostate	104.5 nTPM
Heart muscle	96.1 nTPM
Eye	90.6 nTPM
Skin	90.6 nTPM
Ovary	85.3 nTPM
Liver	78.0 nTPM
Esophagus	53.1 nTPM
Endometrium	47.3 nTPM
Lung	40.6 nTPM

Enteroendocrine cells	113.8 nTPM
Colon	120.8 nTPM
Rectum	106.8 nTPM

Fibroblasts	89.0 nTPM
Heart muscle	190.7 nTPM
Placenta	113.9 nTPM
Prostate	92.8 nTPM
Lung	87.1 nTPM
Ovary	85.8 nTPM
Adipose tissue	83.4 nTPM
Stomach	77.2 nTPM
Skin	66.5 nTPM
Esophagus	63.7 nTPM
Skeletal muscle	58.9 nTPM
Breast	58.8 nTPM

Intestinal goblet cells	224.4 nTPM
Colon	278.0 nTPM
Rectum	234.1 nTPM
Small intestine	160.9 nTPM

Macrophages	104.6 nTPM
Ovary	177.5 nTPM
Pancreas	173.6 nTPM
Prostate	171.9 nTPM
Kidney	145.2 nTPM
Testis	119.1 nTPM
Spleen	118.2 nTPM
Adipose tissue	107.9 nTPM
Bone marrow	85.0 nTPM
Breast	84.3 nTPM
Stomach	79.1 nTPM
Endometrium	74.8 nTPM
Skeletal muscle	69.1 nTPM
Lung	57.3 nTPM
PBMC	54.6 nTPM
Esophagus	51.9 nTPM

Paneth cells	214.0 nTPM
Rectum	268.4 nTPM
Colon	200.9 nTPM
Small intestine	172.8 nTPM

Plasma cells	72.9 nTPM
Bone marrow	103.8 nTPM
Spleen	96.0 nTPM
Stomach	88.0 nTPM
Adipose tissue	40.0 nTPM
Esophagus	36.9 nTPM

Respiratory ciliated cells	110.2 nTPM
Bronchus	141.6 nTPM
Lung	78.7 nTPM

Smooth muscle cells	109.5 nTPM
Prostate	171.0 nTPM
Pancreas	137.1 nTPM
Skin	119.7 nTPM
Heart muscle	118.8 nTPM
Skeletal muscle	117.5 nTPM
Bronchus	115.1 nTPM
Ovary	98.8 nTPM
Adipose tissue	94.0 nTPM
Breast	89.8 nTPM
Esophagus	85.3 nTPM
Endometrium	57.3 nTPM

Basal prostatic cells	190.8 nTPM
Prostate	190.8 nTPM

Basal respiratory cells	444.0 nTPM
Bronchus	444.0 nTPM

Basal squamous epithelial cells	74.6 nTPM
Esophagus	74.6 nTPM

Cholangiocytes	84.4 nTPM
Liver	84.4 nTPM

T-cells	91.3 nTPM
Colon	146.4 nTPM
PBMC	141.2 nTPM
Kidney	133.4 nTPM
Skin	117.4 nTPM
Liver	115.3 nTPM
Prostate	104.2 nTPM
Breast	87.8 nTPM
Spleen	84.9 nTPM
Lymph node	82.1 nTPM
Stomach	80.3 nTPM
Ovary	80.1 nTPM
Adipose tissue	79.4 nTPM
Skeletal muscle	75.6 nTPM
Bone marrow	65.7 nTPM
Endometrium	62.8 nTPM
Esophagus	52.4 nTPM
Lung	42.6 nTPM

Undifferentiated cells	358.7 nTPM
Colon	421.9 nTPM
Rectum	344.7 nTPM
Small intestine	309.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC