Single cell type - DPP8 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DPP8
Gene descriptionⁱ Full gene name according to HGNC.	Dipeptidyl peptidase 8
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	11

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatocytes - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

DPP8 is part of cluster 66 Spermatocytes - Spermatogenesis with confidenceⁱ 1
507 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
FAM217B	Family with sequence similarity 217 member B	0.5023	52
PCM1	Pericentriolar material 1	0.4394	66
DCAF5	DDB1 and CUL4 associated factor 5	0.4369	34
TRIP12	Thyroid hormone receptor interactor 12	0.4352	44
SPG11	SPG11 vesicle trafficking associated, spatacsin	0.4262	52
HSPBAP1	HSPB1 associated protein 1	0.4181	66
GIT2	GIT ArfGAP 2	0.4181	52
CPSF7	Cleavage and polyadenylation specific factor 7	0.4180	23
CRBN	Cereblon	0.4152	66
ZNF546	Zinc finger protein 546	0.4144	66
ZNF174	Zinc finger protein 174	0.4132	66
PDE6D	Phosphodiesterase 6D	0.4107	66
CNOT10	CCR4-NOT transcription complex subunit 10	0.4082	66
EFCAB14	EF-hand calcium binding domain 14	0.4026	14
PCYT1A	Phosphate cytidylyltransferase 1, choline, alpha	0.4024	39

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	39.1 nTPM
Adipose tissue	40.4 nTPM
Breast	37.7 nTPM

Alveolar cells type 1	35.3 nTPM
Lung	35.3 nTPM

Alveolar cells type 2	27.9 nTPM
Lung	27.9 nTPM

Astrocytes	65.6 nTPM
Brain	65.6 nTPM

B-cells	30.0 nTPM
Spleen	40.1 nTPM
Lymph node	38.3 nTPM
Bone marrow	36.8 nTPM
PBMC	34.3 nTPM
Kidney	33.4 nTPM
Adipose tissue	29.1 nTPM
Stomach	28.6 nTPM
Liver	25.8 nTPM
Colon	19.2 nTPM
Breast	14.7 nTPM

Dendritic cells	35.3 nTPM
Adipose tissue	57.0 nTPM
Breast	28.8 nTPM
PBMC	20.0 nTPM

Endothelial cells	39.5 nTPM
Testis	61.9 nTPM
Ovary	56.5 nTPM
Heart muscle	55.8 nTPM
Lung	49.9 nTPM
Skeletal muscle	48.9 nTPM
Liver	44.9 nTPM
Esophagus	38.4 nTPM
Endometrium	34.7 nTPM
Breast	34.6 nTPM
Eye	34.0 nTPM
Prostate	31.7 nTPM
Skin	26.5 nTPM
Placenta	20.5 nTPM
Pancreas	15.5 nTPM

Fibroblasts	22.3 nTPM
Heart muscle	52.1 nTPM
Ovary	26.5 nTPM
Skeletal muscle	25.6 nTPM
Esophagus	21.1 nTPM
Prostate	20.6 nTPM
Skin	19.5 nTPM
Adipose tissue	18.5 nTPM
Stomach	16.3 nTPM
Placenta	15.6 nTPM
Breast	15.2 nTPM
Lung	14.5 nTPM

Intestinal goblet cells	27.0 nTPM
Rectum	33.9 nTPM
Small intestine	29.9 nTPM
Colon	17.2 nTPM

Macrophages	31.9 nTPM
Bone marrow	48.7 nTPM
Testis	45.3 nTPM
Spleen	42.5 nTPM
Skeletal muscle	38.3 nTPM
Ovary	36.8 nTPM
Esophagus	34.6 nTPM
Lung	34.3 nTPM
Adipose tissue	32.5 nTPM
Stomach	32.2 nTPM
Kidney	28.7 nTPM
Pancreas	28.0 nTPM
Prostate	22.9 nTPM
Breast	22.8 nTPM
Endometrium	17.7 nTPM
PBMC	13.6 nTPM

Paneth cells	25.8 nTPM
Rectum	35.1 nTPM
Small intestine	22.5 nTPM
Colon	19.7 nTPM

Plasma cells	24.7 nTPM
Adipose tissue	40.0 nTPM
Spleen	24.5 nTPM
Stomach	23.6 nTPM
Bone marrow	23.0 nTPM
Esophagus	12.3 nTPM

Respiratory ciliated cells	25.9 nTPM
Bronchus	27.1 nTPM
Lung	24.8 nTPM

Smooth muscle cells	22.1 nTPM
Heart muscle	36.1 nTPM
Skeletal muscle	29.9 nTPM
Adipose tissue	24.5 nTPM
Pancreas	24.1 nTPM
Ovary	22.3 nTPM
Esophagus	20.1 nTPM
Breast	19.5 nTPM
Endometrium	19.4 nTPM
Prostate	18.1 nTPM
Skin	16.4 nTPM
Bronchus	13.0 nTPM

T-cells	28.5 nTPM
Skeletal muscle	44.5 nTPM
Liver	39.1 nTPM
Adipose tissue	35.7 nTPM
Bone marrow	34.8 nTPM
Lymph node	34.0 nTPM
Spleen	32.6 nTPM
PBMC	30.6 nTPM
Lung	28.8 nTPM
Colon	28.5 nTPM
Stomach	28.0 nTPM
Endometrium	27.4 nTPM
Breast	25.7 nTPM
Ovary	24.5 nTPM
Kidney	23.3 nTPM
Esophagus	19.7 nTPM
Skin	17.1 nTPM
Prostate	9.5 nTPM

Basal keratinocytes	13.4 nTPM
Skin	13.4 nTPM

Basal prostatic cells	15.0 nTPM
Prostate	15.0 nTPM

Basal respiratory cells	20.4 nTPM
Bronchus	20.4 nTPM

Basal squamous epithelial cells	15.9 nTPM
Esophagus	15.9 nTPM

Undifferentiated cells	26.7 nTPM
Rectum	33.8 nTPM
Small intestine	26.6 nTPM
Colon	19.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC