Single cell type - SLC25A43 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SLC25A43
Gene descriptionⁱ Full gene name according to HGNC.	Solute carrier family 25 member 43
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Intestinal epithelial cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Oligodendrocyte precursor cells, Astrocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Oligodendrocyte precursor cells, Astrocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

SLC25A43 is part of cluster 53 Intestinal epithelial cells - Unknown function with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
B3GALT5	Beta-1,3-galactosyltransferase 5	0.5188	53
EPCAM	Epithelial cell adhesion molecule	0.5095	53
LMO3	LIM domain only 3	0.5026	21
LGALS3	Galectin 3	0.5008	53
ZBTB7C	Zinc finger and BTB domain containing 7C	0.4890	61
POF1B	POF1B actin binding protein	0.4815	53
S100A10	S100 calcium binding protein A10	0.4801	16
ACVR2A	Activin A receptor type 2A	0.4789	8
HEPH	Hephaestin	0.4668	53
DAGLA	Diacylglycerol lipase alpha	0.4639	21
CDX2	Caudal type homeobox 2	0.4607	53
NIPAL2	NIPA like domain containing 2	0.4605	21
LGALS4	Galectin 4	0.4582	53
PRR15L	Proline rich 15 like	0.4563	45
TTC22	Tetratricopeptide repeat domain 22	0.4550	53

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	8.3 nTPM
Breast	9.1 nTPM
Adipose tissue	7.5 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	9.7 nTPM
Lung	9.7 nTPM

B-cells	8.0 nTPM
PBMC	12.9 nTPM
Spleen	12.5 nTPM
Lymph node	10.0 nTPM
Stomach	9.6 nTPM
Adipose tissue	8.1 nTPM
Colon	8.0 nTPM
Bone marrow	7.4 nTPM
Kidney	4.8 nTPM
Breast	4.0 nTPM
Liver	3.3 nTPM

Basal keratinocytes	7.8 nTPM
Skin	7.8 nTPM

Dendritic cells	9.1 nTPM
PBMC	16.0 nTPM
Breast	7.2 nTPM
Adipose tissue	4.0 nTPM

Endothelial cells	6.9 nTPM
Lung	12.5 nTPM
Skin	11.4 nTPM
Skeletal muscle	8.8 nTPM
Testis	8.0 nTPM
Esophagus	7.8 nTPM
Breast	7.7 nTPM
Heart muscle	7.3 nTPM
Ovary	6.8 nTPM
Liver	6.4 nTPM
Prostate	4.8 nTPM
Endometrium	4.2 nTPM
Placenta	4.0 nTPM
Pancreas	3.9 nTPM
Eye	3.3 nTPM

Fibroblasts	11.8 nTPM
Adipose tissue	21.0 nTPM
Skeletal muscle	18.4 nTPM
Esophagus	17.0 nTPM
Skin	14.1 nTPM
Breast	12.2 nTPM
Placenta	11.3 nTPM
Stomach	10.4 nTPM
Prostate	7.2 nTPM
Ovary	6.8 nTPM
Heart muscle	6.0 nTPM
Lung	5.6 nTPM

Intestinal goblet cells	9.6 nTPM
Rectum	18.5 nTPM
Small intestine	7.5 nTPM
Colon	2.9 nTPM

Macrophages	7.5 nTPM
Pancreas	12.8 nTPM
Ovary	12.7 nTPM
Adipose tissue	10.1 nTPM
Lung	9.4 nTPM
Breast	9.2 nTPM
Testis	8.8 nTPM
Skeletal muscle	8.2 nTPM
Prostate	8.1 nTPM
Spleen	7.2 nTPM
Kidney	6.1 nTPM
Stomach	5.9 nTPM
Endometrium	5.4 nTPM
Bone marrow	5.0 nTPM
Esophagus	3.1 nTPM
PBMC	0.0 nTPM

Paneth cells	11.4 nTPM
Rectum	20.5 nTPM
Colon	9.9 nTPM
Small intestine	3.7 nTPM

Plasma cells	2.8 nTPM
Stomach	5.8 nTPM
Bone marrow	5.0 nTPM
Spleen	2.6 nTPM
Adipose tissue	0.6 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	2.0 nTPM
Bronchus	2.5 nTPM
Lung	1.5 nTPM

Smooth muscle cells	9.2 nTPM
Pancreas	21.3 nTPM
Heart muscle	20.0 nTPM
Bronchus	11.5 nTPM
Adipose tissue	9.7 nTPM
Skin	8.0 nTPM
Breast	7.9 nTPM
Endometrium	6.2 nTPM
Skeletal muscle	6.2 nTPM
Ovary	4.0 nTPM
Prostate	3.7 nTPM
Esophagus	3.1 nTPM

T-cells	6.8 nTPM
Skin	12.9 nTPM
Prostate	9.5 nTPM
Bone marrow	9.3 nTPM
Skeletal muscle	8.2 nTPM
Stomach	8.1 nTPM
Lung	7.6 nTPM
Breast	7.3 nTPM
Colon	7.1 nTPM
Esophagus	6.6 nTPM
Liver	6.1 nTPM
Spleen	5.7 nTPM
Kidney	5.5 nTPM
Ovary	4.5 nTPM
Adipose tissue	4.5 nTPM
PBMC	4.4 nTPM
Lymph node	4.2 nTPM
Endometrium	3.9 nTPM

Astrocytes	30.7 nTPM
Brain	30.7 nTPM

Cytotrophoblasts	11.9 nTPM
Placenta	11.9 nTPM

Distal tubular cells	9.8 nTPM
Kidney	9.8 nTPM

Excitatory neurons	10.3 nTPM
Brain	10.3 nTPM

Undifferentiated cells	12.2 nTPM
Rectum	16.5 nTPM
Small intestine	10.3 nTPM
Colon	9.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC