Single cell type - S100A10 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	S100A10
Gene descriptionⁱ Full gene name according to HGNC.	S100 calcium binding protein A10
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Pancreatic endocrine cells - Mixed function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Pancreatic endocrine cells, Langerhans cells, Distal enterocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (OE19)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Pancreatic endocrine cells, Langerhans cells, Distal enterocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

S100A10 is part of cluster 16 Pancreatic endocrine cells - Mixed function with confidenceⁱ 1
171 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
S100A6	S100 calcium binding protein A6	0.8242	16
C19orf33	Chromosome 19 open reading frame 33	0.7949	16
MMP1	Matrix metallopeptidase 1	0.7231	16
CLTB	Clathrin light chain B	0.7189	16
FAM25G	Family with sequence similarity 25 member G	0.7169	16
CBSL	Cystathionine beta-synthase like	0.7141	16
LYNX1-SLURP2	LYNX1-SLURP2 readthrough	0.7133	16
LCE3E	Late cornified envelope 3E	0.7132	16
TMSB10	Thymosin beta 10	0.7115	16
SMIM31	Small integral membrane protein 31	0.7065	16
MUCL3	Mucin like 3	0.7056	16
TFF1	Trefoil factor 1	0.7043	16
KPNA7	Karyopherin subunit alpha 7	0.6876	16
C15orf48	Chromosome 15 open reading frame 48	0.6783	16
ANXA10	Annexin A10	0.6700	16

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	1197.3 nTPM
Adipose tissue	1327.3 nTPM
Breast	1067.4 nTPM

Alveolar cells type 1	2554.5 nTPM
Lung	2554.5 nTPM

Alveolar cells type 2	537.7 nTPM
Lung	537.7 nTPM

Astrocytes	3.9 nTPM
Brain	3.9 nTPM

B-cells	244.0 nTPM
Adipose tissue	729.3 nTPM
Breast	351.7 nTPM
Colon	260.4 nTPM
Kidney	219.0 nTPM
Stomach	193.9 nTPM
Liver	193.4 nTPM
PBMC	148.5 nTPM
Bone marrow	122.6 nTPM
Spleen	118.0 nTPM
Lymph node	103.6 nTPM

Basal squamous epithelial cells	795.6 nTPM
Esophagus	795.6 nTPM

Dendritic cells	476.2 nTPM
Adipose tissue	684.9 nTPM
Breast	648.0 nTPM
PBMC	95.6 nTPM

Distal enterocytes	3820.4 nTPM
Rectum	5408.7 nTPM
Colon	2232.1 nTPM

Endothelial cells	1061.2 nTPM
Skin	1873.4 nTPM
Testis	1711.7 nTPM
Prostate	1491.0 nTPM
Lung	1391.1 nTPM
Skeletal muscle	1299.9 nTPM
Ovary	1253.3 nTPM
Placenta	1132.3 nTPM
Breast	965.1 nTPM
Liver	954.8 nTPM
Esophagus	733.9 nTPM
Endometrium	579.3 nTPM
Heart muscle	534.8 nTPM
Pancreas	528.9 nTPM
Eye	407.8 nTPM

Enteroendocrine cells	1078.1 nTPM
Rectum	1463.4 nTPM
Colon	692.8 nTPM

Erythroid cells	114.2 nTPM
Liver	144.4 nTPM
Bone marrow	84.1 nTPM

Fibroblasts	1751.3 nTPM
Adipose tissue	4653.5 nTPM
Skin	2946.0 nTPM
Placenta	2435.0 nTPM
Lung	2288.8 nTPM
Skeletal muscle	2147.2 nTPM
Breast	1431.0 nTPM
Stomach	1189.4 nTPM
Esophagus	849.3 nTPM
Prostate	617.4 nTPM
Heart muscle	539.2 nTPM
Ovary	167.4 nTPM

Glandular and luminal cells	1270.7 nTPM
Endometrium	1270.7 nTPM

Intestinal goblet cells	1723.1 nTPM
Rectum	2365.5 nTPM
Colon	1751.1 nTPM
Small intestine	1052.8 nTPM

Macrophages	1338.1 nTPM
Adipose tissue	3674.5 nTPM
Testis	2220.9 nTPM
Stomach	2174.2 nTPM
Lung	1749.0 nTPM
Skeletal muscle	1716.0 nTPM
Kidney	1504.1 nTPM
Prostate	1139.4 nTPM
Endometrium	941.3 nTPM
Pancreas	934.1 nTPM
Spleen	863.7 nTPM
Breast	844.8 nTPM
Esophagus	790.0 nTPM
Bone marrow	726.0 nTPM
Ovary	643.1 nTPM
PBMC	150.1 nTPM

Cholangiocytes	693.4 nTPM
Liver	693.4 nTPM

Collecting duct cells	950.9 nTPM
Kidney	950.9 nTPM

Cone photoreceptor cells	4.2 nTPM
Eye	4.2 nTPM

Cytotrophoblasts	1271.5 nTPM
Placenta	1271.5 nTPM

Paneth cells	3391.8 nTPM
Rectum	3976.2 nTPM
Colon	3563.8 nTPM
Small intestine	2635.6 nTPM

Plasma cells	244.5 nTPM
Adipose tissue	523.8 nTPM
Esophagus	246.5 nTPM
Bone marrow	189.5 nTPM
Stomach	149.2 nTPM
Spleen	113.7 nTPM

Respiratory ciliated cells	620.3 nTPM
Bronchus	688.2 nTPM
Lung	552.4 nTPM

Smooth muscle cells	529.5 nTPM
Bronchus	1788.7 nTPM
Ovary	1140.2 nTPM
Pancreas	769.0 nTPM
Skin	541.1 nTPM
Adipose tissue	535.5 nTPM
Skeletal muscle	324.0 nTPM
Prostate	265.7 nTPM
Breast	167.6 nTPM
Heart muscle	144.6 nTPM
Esophagus	94.6 nTPM
Endometrium	53.5 nTPM

T-cells	801.0 nTPM
Adipose tissue	2558.4 nTPM
Skin	2210.4 nTPM
Skeletal muscle	1716.8 nTPM
Breast	737.3 nTPM
Ovary	671.8 nTPM
Kidney	663.3 nTPM
Prostate	639.0 nTPM
Lung	549.8 nTPM
Spleen	515.7 nTPM
PBMC	513.3 nTPM
Esophagus	471.7 nTPM
Bone marrow	443.2 nTPM
Stomach	429.6 nTPM
Endometrium	416.4 nTPM
Liver	411.3 nTPM
Colon	404.4 nTPM
Lymph node	264.2 nTPM

Undifferentiated cells	1998.0 nTPM
Rectum	3171.8 nTPM
Colon	1768.7 nTPM
Small intestine	1053.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC