Single cell type - PIAS2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PIAS2
Gene descriptionⁱ Full gene name according to HGNC.	Protein inhibitor of activated STAT 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatocytes - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Early spermatids, Late spermatids, Spermatocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Early spermatids, Late spermatids, Spermatocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PIAS2 is part of cluster 66 Spermatocytes - Spermatogenesis with confidenceⁱ 1
507 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
EFCAB5	EF-hand calcium binding domain 5	0.7078	66
SPATA4	Spermatogenesis associated 4	0.6581	66
AHRR	Aryl-hydrocarbon receptor repressor	0.6069	66
C22orf23	Chromosome 22 open reading frame 23	0.5956	66
NDUFAF7	NADH:ubiquinone oxidoreductase complex assembly factor 7	0.5909	66
ZNF846	Zinc finger protein 846	0.5892	66
CDRT1	CMT1A duplicated region transcript 1	0.5715	66
BBIP1	BBSome interacting protein 1	0.5568	66
LDHAL6A	Lactate dehydrogenase A like 6A	0.5499	66
WDR53	WD repeat domain 53	0.5498	66
WDR48	WD repeat domain 48	0.5438	66
WDR88	WD repeat domain 88	0.5376	66
MFSD6L	Major facilitator superfamily domain containing 6 like	0.5293	66
SLC26A8	Solute carrier family 26 member 8	0.5259	66
ART5	ADP-ribosyltransferase 5	0.5252	66

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	26.3 nTPM
Adipose tissue	32.1 nTPM
Breast	20.4 nTPM

Alveolar cells type 1	19.2 nTPM
Lung	19.2 nTPM

Alveolar cells type 2	21.9 nTPM
Lung	21.9 nTPM

Astrocytes	60.4 nTPM
Brain	60.4 nTPM

B-cells	25.0 nTPM
Colon	36.7 nTPM
Lymph node	34.2 nTPM
Adipose tissue	33.6 nTPM
Stomach	26.3 nTPM
PBMC	25.7 nTPM
Bone marrow	22.9 nTPM
Spleen	21.1 nTPM
Breast	20.0 nTPM
Liver	15.6 nTPM
Kidney	14.3 nTPM

Dendritic cells	32.8 nTPM
Adipose tissue	41.9 nTPM
PBMC	31.8 nTPM
Breast	24.8 nTPM

Endothelial cells	26.0 nTPM
Ovary	37.9 nTPM
Endometrium	37.8 nTPM
Heart muscle	33.4 nTPM
Testis	32.9 nTPM
Skeletal muscle	31.3 nTPM
Liver	27.5 nTPM
Prostate	27.2 nTPM
Esophagus	25.8 nTPM
Placenta	24.5 nTPM
Eye	22.7 nTPM
Breast	22.3 nTPM
Skin	19.1 nTPM
Pancreas	15.5 nTPM
Lung	6.2 nTPM

Fibroblasts	20.6 nTPM
Ovary	32.7 nTPM
Skin	25.6 nTPM
Prostate	24.4 nTPM
Skeletal muscle	21.8 nTPM
Adipose tissue	21.1 nTPM
Esophagus	20.1 nTPM
Breast	20.1 nTPM
Placenta	16.9 nTPM
Heart muscle	15.2 nTPM
Stomach	14.9 nTPM
Lung	13.4 nTPM

Intestinal goblet cells	18.0 nTPM
Rectum	27.3 nTPM
Colon	15.7 nTPM
Small intestine	11.1 nTPM

Macrophages	24.2 nTPM
Adipose tissue	46.6 nTPM
Ovary	45.0 nTPM
Testis	40.1 nTPM
Skeletal muscle	37.7 nTPM
Prostate	33.2 nTPM
Esophagus	28.3 nTPM
Breast	27.5 nTPM
Spleen	21.8 nTPM
Bone marrow	17.5 nTPM
Endometrium	16.7 nTPM
Lung	16.6 nTPM
Kidney	12.9 nTPM
Stomach	11.7 nTPM
Pancreas	7.7 nTPM
PBMC	0.0 nTPM

Paneth cells	17.1 nTPM
Rectum	26.0 nTPM
Small intestine	18.8 nTPM
Colon	6.5 nTPM

Plasma cells	30.3 nTPM
Adipose tissue	52.2 nTPM
Bone marrow	31.3 nTPM
Esophagus	30.7 nTPM
Spleen	19.8 nTPM
Stomach	17.7 nTPM

Respiratory ciliated cells	13.9 nTPM
Bronchus	16.1 nTPM
Lung	11.7 nTPM

Smooth muscle cells	18.2 nTPM
Bronchus	28.5 nTPM
Heart muscle	23.9 nTPM
Endometrium	21.1 nTPM
Prostate	18.5 nTPM
Skin	17.8 nTPM
Adipose tissue	17.0 nTPM
Esophagus	17.0 nTPM
Ovary	16.9 nTPM
Breast	14.3 nTPM
Skeletal muscle	14.0 nTPM
Pancreas	11.4 nTPM

T-cells	19.2 nTPM
PBMC	33.1 nTPM
Skeletal muscle	30.4 nTPM
Adipose tissue	29.0 nTPM
Lymph node	28.6 nTPM
Breast	24.0 nTPM
Liver	22.8 nTPM
Esophagus	19.7 nTPM
Spleen	18.8 nTPM
Bone marrow	17.9 nTPM
Endometrium	17.4 nTPM
Kidney	17.1 nTPM
Skin	16.6 nTPM
Prostate	14.2 nTPM
Ovary	13.4 nTPM
Lung	12.2 nTPM
Stomach	7.9 nTPM
Colon	2.9 nTPM

Basal prostatic cells	19.9 nTPM
Prostate	19.9 nTPM

Cholangiocytes	12.8 nTPM
Liver	12.8 nTPM

Cone photoreceptor cells	89.6 nTPM
Eye	89.6 nTPM

Cytotrophoblasts	2.6 nTPM
Placenta	2.6 nTPM

Undifferentiated cells	25.5 nTPM
Rectum	37.4 nTPM
Colon	21.3 nTPM
Small intestine	17.8 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC