Single cell type - TOLLIP - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TOLLIP
Gene descriptionⁱ Full gene name according to HGNC.	Toll interacting protein
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatids - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TOLLIP is part of cluster 31 Spermatids - Spermatogenesis with confidenceⁱ 1
413 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PAOX	Polyamine oxidase	0.6418	31
PIAS4	Protein inhibitor of activated STAT 4	0.6368	31
TUSC2	Tumor suppressor 2, mitochondrial calcium regulator	0.6232	31
KLK13	Kallikrein related peptidase 13	0.6203	31
DCAF10	DDB1 and CUL4 associated factor 10	0.6079	31
MRGBP	MRG domain binding protein	0.6073	31
ELOF1	Elongation factor 1 homolog	0.6046	25
GPX4	Glutathione peroxidase 4	0.6010	31
OSGIN1	Oxidative stress induced growth inhibitor 1	0.6006	25
MTFR1L	Mitochondrial fission regulator 1 like	0.5927	31
PAQR9	Progestin and adipoQ receptor family member 9	0.5912	31
EXOSC4	Exosome component 4	0.5906	31
MAD1L1	Mitotic arrest deficient 1 like 1	0.5903	31
POMC	Proopiomelanocortin	0.5889	25
ZNF213	Zinc finger protein 213	0.5852	31

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	19.5 nTPM
Breast	21.6 nTPM
Adipose tissue	17.4 nTPM

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	19.3 nTPM
Lung	19.3 nTPM

Astrocytes	15.0 nTPM
Brain	15.0 nTPM

B-cells	27.8 nTPM
Colon	43.2 nTPM
Liver	36.6 nTPM
Stomach	32.7 nTPM
Spleen	31.1 nTPM
Kidney	28.5 nTPM
PBMC	24.3 nTPM
Bone marrow	23.7 nTPM
Lymph node	20.8 nTPM
Adipose tissue	20.1 nTPM
Breast	17.3 nTPM

Dendritic cells	28.0 nTPM
PBMC	31.8 nTPM
Adipose tissue	26.1 nTPM
Breast	25.9 nTPM

Endothelial cells	24.9 nTPM
Liver	40.3 nTPM
Prostate	35.0 nTPM
Ovary	33.0 nTPM
Testis	32.6 nTPM
Pancreas	30.9 nTPM
Eye	30.7 nTPM
Placenta	26.1 nTPM
Skin	26.0 nTPM
Breast	20.6 nTPM
Esophagus	18.1 nTPM
Endometrium	16.0 nTPM
Skeletal muscle	15.3 nTPM
Heart muscle	14.1 nTPM
Lung	9.3 nTPM

Fibroblasts	27.6 nTPM
Prostate	40.5 nTPM
Stomach	35.6 nTPM
Skin	32.9 nTPM
Placenta	30.5 nTPM
Breast	30.1 nTPM
Heart muscle	29.6 nTPM
Adipose tissue	28.4 nTPM
Esophagus	27.6 nTPM
Skeletal muscle	22.1 nTPM
Ovary	21.1 nTPM
Lung	5.6 nTPM

Intestinal goblet cells	30.8 nTPM
Small intestine	36.7 nTPM
Rectum	30.7 nTPM
Colon	25.0 nTPM

Macrophages	48.3 nTPM
Pancreas	114.9 nTPM
PBMC	95.5 nTPM
Stomach	70.3 nTPM
Kidney	60.5 nTPM
Ovary	52.4 nTPM
Bone marrow	46.2 nTPM
Spleen	44.6 nTPM
Skeletal muscle	40.3 nTPM
Prostate	38.9 nTPM
Adipose tissue	33.3 nTPM
Lung	29.8 nTPM
Breast	28.0 nTPM
Testis	27.8 nTPM
Endometrium	25.6 nTPM
Esophagus	15.8 nTPM

Paneth cells	53.7 nTPM
Colon	79.0 nTPM
Small intestine	41.3 nTPM
Rectum	40.9 nTPM

Plasma cells	33.4 nTPM
Esophagus	43.0 nTPM
Stomach	37.6 nTPM
Bone marrow	36.2 nTPM
Spleen	31.2 nTPM
Adipose tissue	18.8 nTPM

Respiratory ciliated cells	15.4 nTPM
Bronchus	22.1 nTPM
Lung	8.7 nTPM

Smooth muscle cells	24.5 nTPM
Pancreas	63.3 nTPM
Heart muscle	34.1 nTPM
Ovary	31.8 nTPM
Skin	27.3 nTPM
Prostate	26.5 nTPM
Breast	18.2 nTPM
Adipose tissue	17.4 nTPM
Skeletal muscle	16.1 nTPM
Endometrium	13.3 nTPM
Bronchus	12.1 nTPM
Esophagus	9.3 nTPM

T-cells	22.0 nTPM
Colon	34.7 nTPM
Kidney	33.6 nTPM
Skin	28.5 nTPM
Liver	27.6 nTPM
Stomach	27.2 nTPM
Spleen	25.5 nTPM
Breast	25.4 nTPM
Adipose tissue	23.5 nTPM
Ovary	22.3 nTPM
Bone marrow	21.9 nTPM
PBMC	20.7 nTPM
Prostate	19.0 nTPM
Lymph node	16.8 nTPM
Skeletal muscle	14.7 nTPM
Endometrium	14.5 nTPM
Lung	12.2 nTPM
Esophagus	6.6 nTPM

Basal keratinocytes	66.9 nTPM
Skin	66.9 nTPM

Basal prostatic cells	43.9 nTPM
Prostate	43.9 nTPM

Basal respiratory cells	71.7 nTPM
Bronchus	71.7 nTPM

Basal squamous epithelial cells	23.3 nTPM
Esophagus	23.3 nTPM

Undifferentiated cells	29.3 nTPM
Rectum	34.0 nTPM
Small intestine	29.6 nTPM
Colon	24.2 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC