Single cell type - FDFT1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FDFT1
Gene descriptionⁱ Full gene name according to HGNC.	Farnesyl-diphosphate farnesyltransferase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	14

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Respiratory epithelial cells - Mucosal defense (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Basal respiratory cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Group enriched (Daudi, RPMI-8226)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Basal respiratory cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

FDFT1 is part of cluster 26 Respiratory epithelial cells - Mucosal defense with confidenceⁱ 1
293 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PGLYRP4	Peptidoglycan recognition protein 4	0.7731	26
SERPINB3	Serpin family B member 3	0.7688	26
ATP12A	ATPase H+/K+ transporting non-gastric alpha2 subunit	0.7432	26
FAM83A	Family with sequence similarity 83 member A	0.7429	26
CXCL1	C-X-C motif chemokine ligand 1	0.7389	26
BPIFA2	BPI fold containing family A member 2	0.7360	26
TMEM45A	Transmembrane protein 45A	0.7352	26
ACAT2	Acetyl-CoA acetyltransferase 2	0.7339	26
PI3	Peptidase inhibitor 3	0.7301	26
SLPI	Secretory leukocyte peptidase inhibitor	0.7236	26
MED24	Mediator complex subunit 24	0.7217	26
SERPINB4	Serpin family B member 4	0.7201	26
CCL20	C-C motif chemokine ligand 20	0.7179	26
BPIFB1	BPI fold containing family B member 1	0.7153	26
IL17C	Interleukin 17C	0.7153	26

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	31.1 nTPM
Adipose tissue	33.4 nTPM
Breast	28.6 nTPM

Alveolar cells type 1	54.5 nTPM
Lung	54.5 nTPM

Alveolar cells type 2	164.1 nTPM
Lung	164.1 nTPM

Astrocytes	67.6 nTPM
Brain	67.6 nTPM

B-cells	78.0 nTPM
Spleen	128.0 nTPM
PBMC	97.1 nTPM
Bone marrow	88.3 nTPM
Kidney	85.7 nTPM
Lymph node	82.0 nTPM
Liver	81.0 nTPM
Stomach	76.7 nTPM
Colon	55.9 nTPM
Adipose tissue	49.7 nTPM
Breast	36.0 nTPM

Dendritic cells	49.4 nTPM
PBMC	67.8 nTPM
Adipose tissue	44.6 nTPM
Breast	35.7 nTPM

Endothelial cells	45.2 nTPM
Placenta	96.7 nTPM
Heart muscle	81.7 nTPM
Ovary	67.0 nTPM
Prostate	58.7 nTPM
Esophagus	44.4 nTPM
Breast	39.5 nTPM
Testis	39.1 nTPM
Eye	38.8 nTPM
Lung	37.4 nTPM
Skin	31.7 nTPM
Pancreas	30.9 nTPM
Skeletal muscle	27.4 nTPM
Liver	21.1 nTPM
Endometrium	18.6 nTPM

Erythroid cells	113.2 nTPM
Liver	155.0 nTPM
Bone marrow	71.4 nTPM

Fibroblasts	37.1 nTPM
Placenta	71.3 nTPM
Esophagus	50.6 nTPM
Prostate	50.5 nTPM
Heart muscle	46.1 nTPM
Ovary	38.6 nTPM
Stomach	38.6 nTPM
Adipose tissue	30.0 nTPM
Skin	21.8 nTPM
Breast	21.4 nTPM
Skeletal muscle	19.6 nTPM
Lung	19.0 nTPM

Intestinal goblet cells	117.4 nTPM
Colon	149.4 nTPM
Rectum	115.3 nTPM
Small intestine	87.5 nTPM

Macrophages	54.3 nTPM
Ovary	119.4 nTPM
Lung	95.5 nTPM
Prostate	74.5 nTPM
Spleen	66.4 nTPM
Esophagus	58.3 nTPM
Kidney	56.0 nTPM
Testis	51.7 nTPM
Stomach	46.9 nTPM
Bone marrow	42.5 nTPM
Adipose tissue	41.5 nTPM
PBMC	40.9 nTPM
Endometrium	35.2 nTPM
Skeletal muscle	32.4 nTPM
Breast	28.6 nTPM
Pancreas	25.5 nTPM

Paneth cells	108.4 nTPM
Colon	187.7 nTPM
Rectum	69.9 nTPM
Small intestine	67.5 nTPM

Plasma cells	50.0 nTPM
Spleen	78.4 nTPM
Esophagus	55.5 nTPM
Bone marrow	51.1 nTPM
Stomach	42.3 nTPM
Adipose tissue	22.5 nTPM

Respiratory ciliated cells	142.6 nTPM
Bronchus	187.6 nTPM
Lung	97.7 nTPM

Smooth muscle cells	74.4 nTPM
Bronchus	196.7 nTPM
Ovary	103.2 nTPM
Esophagus	100.8 nTPM
Pancreas	90.5 nTPM
Prostate	69.7 nTPM
Heart muscle	65.2 nTPM
Skin	62.4 nTPM
Breast	42.6 nTPM
Adipose tissue	36.0 nTPM
Skeletal muscle	26.0 nTPM
Endometrium	25.3 nTPM

Basal keratinocytes	52.5 nTPM
Skin	52.5 nTPM

Basal prostatic cells	94.0 nTPM
Prostate	94.0 nTPM

Cholangiocytes	101.5 nTPM
Liver	101.5 nTPM

Collecting duct cells	79.1 nTPM
Kidney	79.1 nTPM

T-cells	55.7 nTPM
Stomach	100.7 nTPM
Kidney	79.4 nTPM
Spleen	72.0 nTPM
Bone marrow	70.9 nTPM
Lymph node	70.7 nTPM
Lung	62.3 nTPM
Esophagus	58.9 nTPM
Skin	56.1 nTPM
Prostate	52.1 nTPM
PBMC	49.2 nTPM
Liver	48.8 nTPM
Colon	44.7 nTPM
Ovary	42.2 nTPM
Adipose tissue	40.1 nTPM
Endometrium	34.8 nTPM
Breast	32.2 nTPM
Skeletal muscle	31.9 nTPM

Undifferentiated cells	100.4 nTPM
Colon	133.1 nTPM
Rectum	84.9 nTPM
Small intestine	83.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC