Single cell type - STX7 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	STX7
Gene descriptionⁱ Full gene name according to HGNC.	Syntaxin 7
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	B-cells - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (naive B-cell, memory B-cell, neutrophil, plasmacytoid DC, non-classical monocyte, myeloid DC, intermediate monocyte, basophil, classical monocyte, eosinophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

STX7 is part of cluster 57 B-cells - Immune response with confidenceⁱ 1
204 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TLR6	Toll like receptor 6	0.7077	57
FGD2	FYVE, RhoGEF and PH domain containing 2	0.7015	57
SYK	Spleen associated tyrosine kinase	0.6801	57
TLR7	Toll like receptor 7	0.6795	57
DRAM2	DNA damage regulated autophagy modulator 2	0.6721	57
RNASE6	Ribonuclease A family member k6	0.6692	41
LY86	Lymphocyte antigen 86	0.6678	57
CD180	CD180 molecule	0.6666	57
CLECL1	C-type lectin like 1	0.6509	57
ARL11	ADP ribosylation factor like GTPase 11	0.6471	57
NRROS	Negative regulator of reactive oxygen species	0.6397	57
HLA-DMB	Major histocompatibility complex, class II, DM beta	0.6331	41
HLA-DOA	Major histocompatibility complex, class II, DO alpha	0.6120	41
CD72	CD72 molecule	0.6081	57
GAPT	GRB2 binding adaptor protein, transmembrane	0.6075	65

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	37.7 nTPM
Breast	41.1 nTPM
Adipose tissue	34.3 nTPM

Alveolar cells type 1	70.5 nTPM
Lung	70.5 nTPM

Alveolar cells type 2	36.5 nTPM
Lung	36.5 nTPM

Astrocytes	34.0 nTPM
Brain	34.0 nTPM

Basal keratinocytes	42.1 nTPM
Skin	42.1 nTPM

B-cells	151.6 nTPM
PBMC	376.9 nTPM
Bone marrow	237.9 nTPM
Kidney	180.9 nTPM
Lymph node	151.6 nTPM
Adipose tissue	133.9 nTPM
Spleen	129.1 nTPM
Stomach	99.5 nTPM
Colon	92.6 nTPM
Liver	59.7 nTPM
Breast	53.6 nTPM

Dendritic cells	111.5 nTPM
PBMC	263.0 nTPM
Adipose tissue	41.3 nTPM
Breast	30.3 nTPM

Endothelial cells	38.3 nTPM
Skin	56.8 nTPM
Lung	56.1 nTPM
Liver	55.0 nTPM
Heart muscle	46.6 nTPM
Breast	45.3 nTPM
Skeletal muscle	45.2 nTPM
Eye	42.9 nTPM
Testis	33.5 nTPM
Esophagus	31.6 nTPM
Placenta	27.8 nTPM
Prostate	27.7 nTPM
Ovary	27.2 nTPM
Pancreas	23.1 nTPM
Endometrium	17.6 nTPM

Fibroblasts	34.1 nTPM
Skin	49.1 nTPM
Esophagus	46.6 nTPM
Skeletal muscle	43.1 nTPM
Adipose tissue	41.5 nTPM
Heart muscle	40.6 nTPM
Breast	40.2 nTPM
Lung	30.1 nTPM
Placenta	29.8 nTPM
Stomach	20.8 nTPM
Ovary	17.0 nTPM
Prostate	15.8 nTPM

Intestinal goblet cells	39.8 nTPM
Rectum	46.6 nTPM
Small intestine	41.4 nTPM
Colon	31.5 nTPM

Macrophages	109.6 nTPM
Ovary	217.0 nTPM
PBMC	177.3 nTPM
Kidney	124.0 nTPM
Testis	123.1 nTPM
Adipose tissue	111.4 nTPM
Spleen	101.6 nTPM
Esophagus	100.7 nTPM
Pancreas	99.5 nTPM
Prostate	98.6 nTPM
Bone marrow	94.9 nTPM
Stomach	90.8 nTPM
Breast	90.5 nTPM
Skeletal muscle	89.4 nTPM
Lung	64.3 nTPM
Endometrium	60.8 nTPM

Paneth cells	63.1 nTPM
Small intestine	82.6 nTPM
Rectum	57.4 nTPM
Colon	49.4 nTPM

Plasma cells	37.3 nTPM
Adipose tissue	49.1 nTPM
Spleen	38.4 nTPM
Esophagus	36.9 nTPM
Bone marrow	34.6 nTPM
Stomach	27.8 nTPM

Respiratory ciliated cells	43.9 nTPM
Bronchus	45.5 nTPM
Lung	42.3 nTPM

Smooth muscle cells	38.6 nTPM
Heart muscle	59.4 nTPM
Adipose tissue	47.9 nTPM
Skin	47.4 nTPM
Skeletal muscle	45.6 nTPM
Breast	45.4 nTPM
Esophagus	38.8 nTPM
Prostate	36.2 nTPM
Ovary	31.7 nTPM
Pancreas	28.7 nTPM
Endometrium	23.6 nTPM
Bronchus	19.7 nTPM

Cholangiocytes	85.8 nTPM
Liver	85.8 nTPM

Cone photoreceptor cells	2.1 nTPM
Eye	2.1 nTPM

Cytotrophoblasts	85.7 nTPM
Placenta	85.7 nTPM

Distal enterocytes	50.8 nTPM
Rectum	66.6 nTPM
Colon	35.1 nTPM

T-cells	24.4 nTPM
Esophagus	45.9 nTPM
Prostate	37.9 nTPM
Kidney	36.3 nTPM
Skeletal muscle	33.4 nTPM
Adipose tissue	27.7 nTPM
PBMC	26.2 nTPM
Lung	21.3 nTPM
Bone marrow	21.2 nTPM
Skin	20.7 nTPM
Spleen	20.7 nTPM
Liver	20.2 nTPM
Ovary	20.1 nTPM
Colon	20.0 nTPM
Breast	17.9 nTPM
Endometrium	16.5 nTPM
Lymph node	15.7 nTPM
Stomach	12.4 nTPM

Undifferentiated cells	28.4 nTPM
Rectum	30.7 nTPM
Small intestine	30.3 nTPM
Colon	24.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC