Single cell type - DRAM2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DRAM2
Gene descriptionⁱ Full gene name according to HGNC.	DNA damage regulated autophagy modulator 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	B-cells - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

DRAM2 is part of cluster 57 B-cells - Immune response with confidenceⁱ 1
204 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
LY86	Lymphocyte antigen 86	0.7894	57
TLR6	Toll like receptor 6	0.7465	57
ARL11	ADP ribosylation factor like GTPase 11	0.7115	57
LAPTM5	Lysosomal protein transmembrane 5	0.7065	57
CR1	Complement C3b/C4b receptor 1 (Knops blood group)	0.6980	57
CD37	CD37 molecule	0.6894	57
CD180	CD180 molecule	0.6820	57
STX7	Syntaxin 7	0.6721	57
FGD2	FYVE, RhoGEF and PH domain containing 2	0.6683	57
ADAM28	ADAM metallopeptidase domain 28	0.6660	57
POU2F2	POU class 2 homeobox 2	0.6559	57
CD72	CD72 molecule	0.6540	57
SCIMP	SLP adaptor and CSK interacting membrane protein	0.6468	57
PTPN6	Protein tyrosine phosphatase non-receptor type 6	0.6307	57
RGS19	Regulator of G protein signaling 19	0.6289	57

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	34.5 nTPM
Breast	41.4 nTPM
Adipose tissue	27.7 nTPM

Alveolar cells type 1	12.8 nTPM
Lung	12.8 nTPM

Alveolar cells type 2	12.0 nTPM
Lung	12.0 nTPM

Astrocytes	17.3 nTPM
Brain	17.3 nTPM

Basal keratinocytes	47.0 nTPM
Skin	47.0 nTPM

B-cells	146.2 nTPM
Kidney	204.7 nTPM
Lymph node	185.1 nTPM
PBMC	174.1 nTPM
Bone marrow	156.1 nTPM
Colon	148.6 nTPM
Stomach	147.6 nTPM
Spleen	147.1 nTPM
Adipose tissue	122.3 nTPM
Liver	93.6 nTPM
Breast	83.0 nTPM

Dendritic cells	38.9 nTPM
PBMC	51.8 nTPM
Breast	39.0 nTPM
Adipose tissue	25.8 nTPM

Endothelial cells	36.4 nTPM
Liver	82.6 nTPM
Placenta	63.1 nTPM
Skin	59.6 nTPM
Breast	47.6 nTPM
Prostate	39.8 nTPM
Esophagus	34.9 nTPM
Eye	32.4 nTPM
Testis	29.9 nTPM
Skeletal muscle	27.5 nTPM
Pancreas	27.0 nTPM
Ovary	21.0 nTPM
Heart muscle	19.4 nTPM
Endometrium	18.2 nTPM
Lung	6.2 nTPM

Fibroblasts	39.2 nTPM
Placenta	118.1 nTPM
Skin	46.7 nTPM
Esophagus	42.6 nTPM
Adipose tissue	42.5 nTPM
Breast	38.9 nTPM
Skeletal muscle	35.0 nTPM
Prostate	33.5 nTPM
Stomach	29.7 nTPM
Heart muscle	17.4 nTPM
Ovary	15.9 nTPM
Lung	11.1 nTPM

Intestinal goblet cells	45.7 nTPM
Small intestine	62.6 nTPM
Rectum	43.7 nTPM
Colon	30.7 nTPM

Macrophages	110.3 nTPM
Ovary	266.4 nTPM
Prostate	221.2 nTPM
Kidney	162.5 nTPM
Spleen	143.1 nTPM
Testis	134.8 nTPM
Skeletal muscle	106.9 nTPM
Bone marrow	103.7 nTPM
Adipose tissue	101.4 nTPM
Breast	89.7 nTPM
Esophagus	88.1 nTPM
Pancreas	71.5 nTPM
Stomach	67.4 nTPM
Lung	49.2 nTPM
Endometrium	48.1 nTPM
PBMC	0.0 nTPM

Paneth cells	64.3 nTPM
Small intestine	90.1 nTPM
Rectum	53.5 nTPM
Colon	49.4 nTPM

Plasma cells	54.7 nTPM
Esophagus	104.7 nTPM
Stomach	68.8 nTPM
Spleen	40.6 nTPM
Bone marrow	33.0 nTPM
Adipose tissue	26.4 nTPM

Respiratory ciliated cells	95.8 nTPM
Bronchus	140.5 nTPM
Lung	51.0 nTPM

Smooth muscle cells	32.5 nTPM
Bronchus	62.8 nTPM
Prostate	56.0 nTPM
Pancreas	40.0 nTPM
Breast	36.8 nTPM
Skin	32.4 nTPM
Skeletal muscle	32.0 nTPM
Adipose tissue	24.7 nTPM
Esophagus	21.7 nTPM
Ovary	18.3 nTPM
Heart muscle	16.9 nTPM
Endometrium	16.4 nTPM

Cholangiocytes	32.9 nTPM
Liver	32.9 nTPM

Collecting duct cells	44.1 nTPM
Kidney	44.1 nTPM

Cone photoreceptor cells	2.1 nTPM
Eye	2.1 nTPM

Cytotrophoblasts	98.1 nTPM
Placenta	98.1 nTPM

T-cells	38.6 nTPM
Kidney	56.9 nTPM
PBMC	56.5 nTPM
Skin	53.9 nTPM
Lymph node	53.5 nTPM
Liver	49.5 nTPM
Esophagus	45.9 nTPM
Spleen	41.3 nTPM
Breast	41.3 nTPM
Colon	37.1 nTPM
Lung	34.9 nTPM
Prostate	33.1 nTPM
Bone marrow	31.6 nTPM
Stomach	27.0 nTPM
Skeletal muscle	25.7 nTPM
Adipose tissue	25.3 nTPM
Ovary	24.5 nTPM
Endometrium	18.7 nTPM

Undifferentiated cells	43.7 nTPM
Small intestine	59.5 nTPM
Rectum	41.5 nTPM
Colon	30.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC