Single cell type - MTIF2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MTIF2
Gene descriptionⁱ Full gene name according to HGNC.	Mitochondrial translational initiation factor 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cardiomyocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cardiomyocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MTIF2 is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 1
586 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
IMMT	Inner membrane mitochondrial protein	0.6298	39
MT-ND1	Mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1	0.5363	54
UQCRHL	Ubiquinol-cytochrome c reductase hinge protein like	0.5359	54
GRSF1	G-rich RNA sequence binding factor 1	0.5297	3
DLAT	Dihydrolipoamide S-acetyltransferase	0.5297	39
RMDN1	Regulator of microtubule dynamics 1	0.5269	39
MRPL35	Mitochondrial ribosomal protein L35	0.5259	39
NDUFAB1	NADH:ubiquinone oxidoreductase subunit AB1	0.5227	39
FITM2	Fat storage inducing transmembrane protein 2	0.5224	54
UQCRB	Ubiquinol-cytochrome c reductase binding protein	0.5209	39
IARS2	Isoleucyl-tRNA synthetase 2, mitochondrial	0.5133	54
MRPS5	Mitochondrial ribosomal protein S5	0.5116	39
PLAAT1	Phospholipase A and acyltransferase 1	0.5113	54
ZNF106	Zinc finger protein 106	0.5109	54
TIMM21	Translocase of inner mitochondrial membrane 21	0.5090	54

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	10.9 nTPM
Breast	13.4 nTPM
Adipose tissue	8.4 nTPM

Alveolar cells type 1	22.4 nTPM
Lung	22.4 nTPM

Alveolar cells type 2	23.6 nTPM
Lung	23.6 nTPM

Astrocytes	9.8 nTPM
Brain	9.8 nTPM

B-cells	16.6 nTPM
Liver	33.8 nTPM
PBMC	24.3 nTPM
Spleen	16.9 nTPM
Adipose tissue	16.1 nTPM
Lymph node	15.0 nTPM
Kidney	14.3 nTPM
Breast	12.1 nTPM
Bone marrow	11.5 nTPM
Colon	11.2 nTPM
Stomach	10.9 nTPM

Dendritic cells	22.2 nTPM
PBMC	39.8 nTPM
Breast	14.9 nTPM
Adipose tissue	12.0 nTPM

Endothelial cells	13.5 nTPM
Heart muscle	36.5 nTPM
Pancreas	27.0 nTPM
Lung	18.7 nTPM
Placenta	17.6 nTPM
Endometrium	15.5 nTPM
Ovary	15.3 nTPM
Skeletal muscle	12.0 nTPM
Breast	10.7 nTPM
Liver	10.1 nTPM
Testis	8.6 nTPM
Esophagus	6.8 nTPM
Skin	6.2 nTPM
Prostate	4.2 nTPM
Eye	0.0 nTPM

Fibroblasts	14.0 nTPM
Heart muscle	36.8 nTPM
Lung	17.9 nTPM
Ovary	16.5 nTPM
Stomach	16.3 nTPM
Skeletal muscle	13.7 nTPM
Placenta	13.2 nTPM
Breast	10.9 nTPM
Adipose tissue	10.8 nTPM
Prostate	6.2 nTPM
Skin	6.0 nTPM
Esophagus	5.9 nTPM

Intestinal goblet cells	19.3 nTPM
Rectum	23.4 nTPM
Small intestine	17.3 nTPM
Colon	17.2 nTPM

Macrophages	19.0 nTPM
Lung	44.9 nTPM
Skeletal muscle	28.2 nTPM
Ovary	28.2 nTPM
Pancreas	25.5 nTPM
Breast	20.4 nTPM
Testis	19.2 nTPM
Adipose tissue	19.0 nTPM
Bone marrow	18.8 nTPM
Spleen	17.6 nTPM
Endometrium	16.7 nTPM
Prostate	15.0 nTPM
Kidney	12.0 nTPM
Stomach	11.7 nTPM
Esophagus	7.9 nTPM
PBMC	0.0 nTPM

Paneth cells	15.3 nTPM
Rectum	27.2 nTPM
Small intestine	18.8 nTPM
Colon	0.0 nTPM

Plasma cells	21.5 nTPM
Spleen	30.9 nTPM
Esophagus	24.6 nTPM
Stomach	23.4 nTPM
Bone marrow	18.2 nTPM
Adipose tissue	10.3 nTPM

Respiratory ciliated cells	22.5 nTPM
Lung	33.5 nTPM
Bronchus	11.5 nTPM

Smooth muscle cells	20.6 nTPM
Heart muscle	55.2 nTPM
Pancreas	34.4 nTPM
Bronchus	31.9 nTPM
Ovary	16.6 nTPM
Endometrium	14.6 nTPM
Esophagus	14.0 nTPM
Breast	13.8 nTPM
Prostate	13.1 nTPM
Adipose tissue	12.7 nTPM
Skeletal muscle	10.8 nTPM
Skin	9.1 nTPM

T-cells	13.3 nTPM
Lung	24.3 nTPM
PBMC	22.6 nTPM
Liver	16.5 nTPM
Lymph node	14.8 nTPM
Prostate	14.2 nTPM
Endometrium	13.4 nTPM
Ovary	13.4 nTPM
Esophagus	13.1 nTPM
Skeletal muscle	12.7 nTPM
Stomach	11.8 nTPM
Breast	11.1 nTPM
Adipose tissue	10.8 nTPM
Bone marrow	10.0 nTPM
Spleen	10.0 nTPM
Kidney	9.6 nTPM
Colon	9.0 nTPM
Skin	8.8 nTPM

Basal keratinocytes	7.6 nTPM
Skin	7.6 nTPM

Basal prostatic cells	19.1 nTPM
Prostate	19.1 nTPM

Basal squamous epithelial cells	13.6 nTPM
Esophagus	13.6 nTPM

Cholangiocytes	22.8 nTPM
Liver	22.8 nTPM

Undifferentiated cells	33.3 nTPM
Rectum	38.0 nTPM
Small intestine	34.3 nTPM
Colon	27.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC