Single cell type - IARS2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	IARS2
Gene descriptionⁱ Full gene name according to HGNC.	Isoleucyl-tRNA synthetase 2, mitochondrial
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Cardiomyocytes - Muscle contraction (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

IARS2 is part of cluster 54 Cardiomyocytes - Muscle contraction with confidenceⁱ 1
250 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
NFE2L1	Nuclear factor, erythroid 2 like 1	0.5336	54
GOT2	Glutamic-oxaloacetic transaminase 2	0.5235	54
FITM2	Fat storage inducing transmembrane protein 2	0.5156	54
MTIF2	Mitochondrial translational initiation factor 2	0.5133	39
MYZAP	Myocardial zonula adherens protein	0.4978	54
PLAAT1	Phospholipase A and acyltransferase 1	0.4969	54
NDUFS1	NADH:ubiquinone oxidoreductase core subunit S1	0.4955	54
MFN2	Mitofusin 2	0.4911	54
ITGB1BP2	Integrin subunit beta 1 binding protein 2	0.4822	54
UTP14C	UTP14C small subunit processome component	0.4730	50
UQCRHL	Ubiquinol-cytochrome c reductase hinge protein like	0.4696	54
NPPA	Natriuretic peptide A	0.4695	54
CS	Citrate synthase	0.4688	54
MYOZ2	Myozenin 2	0.4683	54
CDIN1	CDAN1 interacting nuclease 1	0.4676	54

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	66.4 nTPM
Adipose tissue	76.6 nTPM
Breast	56.2 nTPM

Alveolar cells type 1	35.3 nTPM
Lung	35.3 nTPM

Alveolar cells type 2	38.0 nTPM
Lung	38.0 nTPM

Astrocytes	15.7 nTPM
Brain	15.7 nTPM

B-cells	30.7 nTPM
Liver	50.3 nTPM
PBMC	42.8 nTPM
Lymph node	40.3 nTPM
Spleen	39.8 nTPM
Bone marrow	35.1 nTPM
Adipose tissue	32.6 nTPM
Stomach	27.7 nTPM
Colon	22.3 nTPM
Breast	10.7 nTPM
Kidney	4.8 nTPM

Dendritic cells	31.5 nTPM
PBMC	39.8 nTPM
Adipose tissue	31.4 nTPM
Breast	23.3 nTPM

Endothelial cells	43.7 nTPM
Lung	77.9 nTPM
Heart muscle	64.4 nTPM
Breast	53.8 nTPM
Ovary	47.7 nTPM
Testis	47.1 nTPM
Pancreas	46.4 nTPM
Eye	43.7 nTPM
Endometrium	43.3 nTPM
Liver	36.7 nTPM
Skeletal muscle	34.8 nTPM
Esophagus	34.6 nTPM
Placenta	32.4 nTPM
Skin	29.1 nTPM
Prostate	20.7 nTPM

Fibroblasts	37.0 nTPM
Heart muscle	69.1 nTPM
Adipose tissue	49.1 nTPM
Lung	42.4 nTPM
Skeletal muscle	41.6 nTPM
Esophagus	39.0 nTPM
Ovary	38.6 nTPM
Stomach	32.7 nTPM
Placenta	29.2 nTPM
Breast	29.0 nTPM
Skin	22.3 nTPM
Prostate	13.7 nTPM

Intestinal goblet cells	55.4 nTPM
Rectum	75.0 nTPM
Colon	47.2 nTPM
Small intestine	43.9 nTPM

Macrophages	35.9 nTPM
Lung	70.4 nTPM
Spleen	60.2 nTPM
Ovary	51.0 nTPM
Esophagus	39.3 nTPM
Pancreas	38.3 nTPM
Bone marrow	37.5 nTPM
Testis	36.6 nTPM
Adipose tissue	36.4 nTPM
Stomach	35.1 nTPM
Endometrium	33.4 nTPM
Skeletal muscle	31.5 nTPM
Kidney	21.9 nTPM
Breast	21.0 nTPM
PBMC	13.6 nTPM
Prostate	11.5 nTPM

Paneth cells	44.9 nTPM
Rectum	71.7 nTPM
Colon	32.9 nTPM
Small intestine	30.0 nTPM

Plasma cells	33.1 nTPM
Spleen	60.5 nTPM
Bone marrow	49.4 nTPM
Adipose tissue	22.5 nTPM
Stomach	20.9 nTPM
Esophagus	12.3 nTPM

Respiratory ciliated cells	62.0 nTPM
Lung	64.1 nTPM
Bronchus	59.9 nTPM

Smooth muscle cells	39.0 nTPM
Heart muscle	72.6 nTPM
Adipose tissue	58.5 nTPM
Ovary	46.4 nTPM
Pancreas	45.2 nTPM
Endometrium	42.3 nTPM
Esophagus	38.8 nTPM
Skeletal muscle	37.4 nTPM
Breast	35.0 nTPM
Skin	23.4 nTPM
Prostate	18.5 nTPM
Bronchus	10.5 nTPM

T-cells	31.0 nTPM
Lymph node	51.1 nTPM
Stomach	46.6 nTPM
PBMC	42.6 nTPM
Adipose tissue	37.9 nTPM
Skeletal muscle	37.8 nTPM
Ovary	37.8 nTPM
Bone marrow	36.3 nTPM
Spleen	33.4 nTPM
Liver	30.6 nTPM
Skin	29.9 nTPM
Endometrium	29.5 nTPM
Lung	28.8 nTPM
Breast	26.1 nTPM
Colon	24.7 nTPM
Kidney	17.8 nTPM
Prostate	9.5 nTPM
Esophagus	6.6 nTPM

Basal keratinocytes	20.1 nTPM
Skin	20.1 nTPM

Basal prostatic cells	28.6 nTPM
Prostate	28.6 nTPM

Basal respiratory cells	44.1 nTPM
Bronchus	44.1 nTPM

Basal squamous epithelial cells	34.7 nTPM
Esophagus	34.7 nTPM

Undifferentiated cells	69.9 nTPM
Rectum	87.2 nTPM
Small intestine	61.3 nTPM
Colon	61.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC