Single cell type - TMED2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TMED2
Gene descriptionⁱ Full gene name according to HGNC.	Transmembrane p24 trafficking protein 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Plasma cells - Humoral immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TMED2 is part of cluster 55 Plasma cells - Humoral immune response with confidenceⁱ 0.93
379 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
NUS1	NUS1 dehydrodolichyl diphosphate synthase subunit	0.6346	55
KDELR2	KDEL endoplasmic reticulum protein retention receptor 2	0.6313	55
SSR1	Signal sequence receptor subunit 1	0.6186	55
JTB	Jumping translocation breakpoint	0.6002	55
SLC33A1	Solute carrier family 33 member 1	0.5980	55
SLC30A5	Solute carrier family 30 member 5	0.5938	38
GOLPH3	Golgi phosphoprotein 3	0.5719	55
MANF	Mesencephalic astrocyte derived neurotrophic factor	0.5708	55
SAR1A	Secretion associated Ras related GTPase 1A	0.5700	10
PDIA5	Protein disulfide isomerase family A member 5	0.5690	38
CALU	Calumenin	0.5675	38
DPAGT1	Dolichyl-phosphate N-acetylglucosaminephosphotransferase 1	0.5640	55
MORF4L2	Mortality factor 4 like 2	0.5615	38
TMED10	Transmembrane p24 trafficking protein 10	0.5441	55
OSTC	Oligosaccharyltransferase complex non-catalytic subunit	0.5441	55

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	97.1 nTPM
Adipose tissue	119.9 nTPM
Breast	74.3 nTPM

Alveolar cells type 1	48.1 nTPM
Lung	48.1 nTPM

Alveolar cells type 2	71.5 nTPM
Lung	71.5 nTPM

Astrocytes	9.1 nTPM
Brain	9.1 nTPM

B-cells	148.8 nTPM
Liver	410.1 nTPM
Breast	176.5 nTPM
Colon	135.8 nTPM
Spleen	126.6 nTPM
Stomach	122.1 nTPM
Kidney	114.3 nTPM
PBMC	114.3 nTPM
Lymph node	109.2 nTPM
Bone marrow	105.5 nTPM
Adipose tissue	73.1 nTPM

Basal squamous epithelial cells	207.1 nTPM
Esophagus	207.1 nTPM

Dendritic cells	166.9 nTPM
PBMC	223.2 nTPM
Breast	145.0 nTPM
Adipose tissue	132.4 nTPM

Endothelial cells	142.0 nTPM
Skin	295.2 nTPM
Prostate	251.3 nTPM
Pancreas	223.9 nTPM
Breast	167.0 nTPM
Esophagus	165.5 nTPM
Placenta	134.7 nTPM
Liver	127.5 nTPM
Ovary	96.1 nTPM
Skeletal muscle	95.6 nTPM
Testis	94.2 nTPM
Heart muscle	94.1 nTPM
Lung	84.2 nTPM
Eye	80.1 nTPM
Endometrium	78.2 nTPM

Enteroendocrine cells	170.7 nTPM
Colon	181.2 nTPM
Rectum	160.1 nTPM

Fibroblasts	242.7 nTPM
Skin	496.8 nTPM
Placenta	399.3 nTPM
Prostate	335.4 nTPM
Esophagus	303.0 nTPM
Adipose tissue	233.6 nTPM
Breast	219.8 nTPM
Stomach	185.6 nTPM
Heart muscle	166.3 nTPM
Ovary	136.4 nTPM
Skeletal muscle	121.0 nTPM
Lung	72.6 nTPM

Intestinal goblet cells	352.4 nTPM
Colon	559.6 nTPM
Rectum	274.6 nTPM
Small intestine	222.9 nTPM

Macrophages	128.5 nTPM
Prostate	227.0 nTPM
Pancreas	206.7 nTPM
Esophagus	201.5 nTPM
Spleen	136.9 nTPM
Adipose tissue	135.9 nTPM
Kidney	134.7 nTPM
Bone marrow	133.7 nTPM
Testis	133.6 nTPM
Stomach	131.9 nTPM
Ovary	112.2 nTPM
Endometrium	107.3 nTPM
Breast	100.4 nTPM
Skeletal muscle	68.7 nTPM
Lung	55.4 nTPM
PBMC	40.9 nTPM

Paneth cells	158.5 nTPM
Rectum	203.7 nTPM
Small intestine	172.8 nTPM
Colon	98.9 nTPM

Plasma cells	521.0 nTPM
Stomach	780.0 nTPM
Spleen	653.4 nTPM
Esophagus	572.8 nTPM
Bone marrow	459.8 nTPM
Adipose tissue	139.3 nTPM

Respiratory ciliated cells	142.1 nTPM
Bronchus	214.3 nTPM
Lung	69.9 nTPM

Cholangiocytes	213.1 nTPM
Liver	213.1 nTPM

Collecting duct cells	154.5 nTPM
Kidney	154.5 nTPM

Cone photoreceptor cells	20.9 nTPM
Eye	20.9 nTPM

Cytotrophoblasts	281.5 nTPM
Placenta	281.5 nTPM

Smooth muscle cells	193.5 nTPM
Pancreas	447.6 nTPM
Skin	262.9 nTPM
Prostate	253.5 nTPM
Esophagus	234.2 nTPM
Bronchus	180.5 nTPM
Heart muscle	171.8 nTPM
Ovary	128.8 nTPM
Adipose tissue	125.2 nTPM
Breast	113.0 nTPM
Skeletal muscle	111.7 nTPM
Endometrium	99.0 nTPM

T-cells	154.3 nTPM
Skin	305.3 nTPM
Prostate	293.5 nTPM
Stomach	192.9 nTPM
Colon	188.6 nTPM
Kidney	183.4 nTPM
Spleen	165.2 nTPM
Liver	159.8 nTPM
Bone marrow	153.0 nTPM
Breast	140.0 nTPM
Lymph node	128.4 nTPM
PBMC	123.4 nTPM
Adipose tissue	120.0 nTPM
Ovary	106.8 nTPM
Skeletal muscle	102.4 nTPM
Esophagus	98.3 nTPM
Endometrium	91.0 nTPM
Lung	71.4 nTPM

Undifferentiated cells	263.9 nTPM
Colon	353.0 nTPM
Rectum	222.7 nTPM
Small intestine	215.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC