Single cell type - DNM1L - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DNM1L
Gene descriptionⁱ Full gene name according to HGNC.	Dynamin 1 like
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Metabolic proteins Plasma proteins Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	11

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Photoreceptor cells - Phototransduction (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

DNM1L is part of cluster 46 Photoreceptor cells - Phototransduction with confidenceⁱ 1
209 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MAP3K12	Mitogen-activated protein kinase kinase kinase 12	0.6122	46
YPEL2	Yippee like 2	0.5518	46
SCAPER	S-phase cyclin A associated protein in the ER	0.5407	46
MAN2A2	Mannosidase alpha class 2A member 2	0.5374	46
BOD1L1	Biorientation of chromosomes in cell division 1 like 1	0.5302	52
KLHL34	Kelch like family member 34	0.5205	46
KCTD7	Potassium channel tetramerization domain containing 7	0.5196	46
EPB41L2	Erythrocyte membrane protein band 4.1 like 2	0.5165	46
AHI1	Abelson helper integration site 1	0.5131	9
GRIPAP1	GRIP1 associated protein 1	0.5071	9
ZNF283	Zinc finger protein 283	0.5034	46
HRNR	Hornerin	0.5001	46
ULK1	Unc-51 like autophagy activating kinase 1	0.4918	46
GPATCH2L	G-patch domain containing 2 like	0.4917	52
ZNF432	Zinc finger protein 432	0.4874	46

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	42.5 nTPM
Adipose tissue	44.8 nTPM
Breast	40.1 nTPM

Alveolar cells type 1	38.5 nTPM
Lung	38.5 nTPM

Alveolar cells type 2	38.4 nTPM
Lung	38.4 nTPM

Astrocytes	82.6 nTPM
Brain	82.6 nTPM

B-cells	36.0 nTPM
Adipose tissue	72.2 nTPM
Stomach	47.2 nTPM
Lymph node	42.3 nTPM
Colon	38.3 nTPM
Spleen	36.4 nTPM
Bone marrow	31.1 nTPM
Liver	27.7 nTPM
Breast	24.1 nTPM
PBMC	21.4 nTPM
Kidney	19.0 nTPM

Dendritic cells	53.8 nTPM
Adipose tissue	81.8 nTPM
PBMC	47.8 nTPM
Breast	31.7 nTPM

Endothelial cells	42.0 nTPM
Lung	62.4 nTPM
Endometrium	53.7 nTPM
Heart muscle	53.5 nTPM
Skeletal muscle	53.0 nTPM
Eye	50.2 nTPM
Ovary	49.2 nTPM
Testis	44.5 nTPM
Prostate	42.9 nTPM
Breast	33.5 nTPM
Esophagus	31.9 nTPM
Skin	29.7 nTPM
Placenta	29.6 nTPM
Pancreas	27.0 nTPM
Liver	26.6 nTPM

Fibroblasts	41.0 nTPM
Heart muscle	75.3 nTPM
Lung	50.3 nTPM
Skeletal muscle	50.3 nTPM
Adipose tissue	44.4 nTPM
Prostate	42.2 nTPM
Stomach	41.6 nTPM
Breast	32.2 nTPM
Esophagus	30.5 nTPM
Ovary	29.3 nTPM
Skin	27.9 nTPM
Placenta	27.5 nTPM

Intestinal goblet cells	24.9 nTPM
Colon	31.5 nTPM
Small intestine	22.9 nTPM
Rectum	20.3 nTPM

Macrophages	43.3 nTPM
Adipose tissue	85.5 nTPM
Endometrium	62.5 nTPM
Lung	53.1 nTPM
Breast	48.7 nTPM
Spleen	44.6 nTPM
Stomach	43.9 nTPM
Pancreas	43.4 nTPM
Skeletal muscle	42.2 nTPM
Esophagus	40.9 nTPM
Prostate	40.1 nTPM
Bone marrow	36.3 nTPM
Ovary	36.0 nTPM
Testis	29.7 nTPM
Kidney	29.5 nTPM
PBMC	13.6 nTPM

Paneth cells	14.4 nTPM
Rectum	21.6 nTPM
Small intestine	15.0 nTPM
Colon	6.5 nTPM

Plasma cells	48.5 nTPM
Adipose tissue	92.9 nTPM
Spleen	43.5 nTPM
Bone marrow	41.2 nTPM
Esophagus	36.9 nTPM
Stomach	28.1 nTPM

Respiratory ciliated cells	22.8 nTPM
Lung	29.1 nTPM
Bronchus	16.5 nTPM

Smooth muscle cells	55.5 nTPM
Heart muscle	138.7 nTPM
Adipose tissue	66.8 nTPM
Skeletal muscle	62.9 nTPM
Endometrium	60.1 nTPM
Ovary	49.6 nTPM
Breast	44.2 nTPM
Prostate	44.1 nTPM
Pancreas	42.8 nTPM
Bronchus	38.6 nTPM
Skin	32.0 nTPM
Esophagus	31.0 nTPM

T-cells	42.2 nTPM
Adipose tissue	92.0 nTPM
Endometrium	70.7 nTPM
Skeletal muscle	69.9 nTPM
Lung	62.3 nTPM
Breast	52.7 nTPM
Stomach	44.5 nTPM
Colon	43.2 nTPM
Lymph node	38.1 nTPM
Prostate	37.9 nTPM
Spleen	32.5 nTPM
Ovary	31.1 nTPM
PBMC	28.7 nTPM
Liver	28.6 nTPM
Bone marrow	25.6 nTPM
Skin	23.0 nTPM
Esophagus	19.7 nTPM
Kidney	17.1 nTPM

Basal keratinocytes	30.0 nTPM
Skin	30.0 nTPM

Basal prostatic cells	34.7 nTPM
Prostate	34.7 nTPM

Basal respiratory cells	28.0 nTPM
Bronchus	28.0 nTPM

Basal squamous epithelial cells	44.3 nTPM
Esophagus	44.3 nTPM

Undifferentiated cells	31.5 nTPM
Colon	42.9 nTPM
Rectum	28.7 nTPM
Small intestine	22.8 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC