Single cell type - GOLGA3 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GOLGA3
Gene descriptionⁱ Full gene name according to HGNC.	Golgin A3
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Photoreceptor cells - Phototransduction (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Rod photoreceptor cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Rod photoreceptor cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

GOLGA3 is part of cluster 46 Photoreceptor cells - Phototransduction with confidenceⁱ 1
209 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CEP170B	Centrosomal protein 170B	0.5473	9
MBTPS1	Membrane bound transcription factor peptidase, site 1	0.5450	46
PGGT1B	Protein geranylgeranyltransferase type I subunit beta	0.5326	46
ABCA4	ATP binding cassette subfamily A member 4	0.5316	46
GRIPAP1	GRIP1 associated protein 1	0.5313	9
ZMYND19	Zinc finger MYND-type containing 19	0.5269	46
ULK1	Unc-51 like autophagy activating kinase 1	0.5253	46
PDE6B	Phosphodiesterase 6B	0.5246	46
ZFYVE26	Zinc finger FYVE-type containing 26	0.5201	46
GUCY2F	Guanylate cyclase 2F, retinal	0.5199	46
SAMD11	Sterile alpha motif domain containing 11	0.5136	46
PRPH2	Peripherin 2	0.5131	46
SPINT4	Serine peptidase inhibitor, Kunitz type 4	0.5114	46
IGFL4	IGF like family member 4	0.5109	46
GRK1	G protein-coupled receptor kinase 1	0.5105	46

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	22.9 nTPM
Breast	23.5 nTPM
Adipose tissue	22.4 nTPM

Alveolar cells type 1	44.8 nTPM
Lung	44.8 nTPM

Alveolar cells type 2	40.6 nTPM
Lung	40.6 nTPM

Astrocytes	25.8 nTPM
Brain	25.8 nTPM

B-cells	22.0 nTPM
Breast	42.8 nTPM
Liver	38.5 nTPM
Stomach	21.4 nTPM
Adipose tissue	21.0 nTPM
Colon	20.8 nTPM
Lymph node	16.1 nTPM
PBMC	15.7 nTPM
Spleen	14.9 nTPM
Bone marrow	14.7 nTPM
Kidney	14.3 nTPM

Dendritic cells	20.6 nTPM
Adipose tissue	26.0 nTPM
Breast	23.6 nTPM
PBMC	12.0 nTPM

Endothelial cells	24.8 nTPM
Lung	43.7 nTPM
Ovary	41.9 nTPM
Heart muscle	40.4 nTPM
Endometrium	34.5 nTPM
Eye	25.9 nTPM
Prostate	23.2 nTPM
Skeletal muscle	22.9 nTPM
Breast	18.3 nTPM
Placenta	18.2 nTPM
Skin	18.2 nTPM
Liver	17.4 nTPM
Pancreas	15.5 nTPM
Testis	13.9 nTPM
Esophagus	12.8 nTPM

Fibroblasts	29.0 nTPM
Skeletal muscle	45.2 nTPM
Heart muscle	42.9 nTPM
Ovary	34.8 nTPM
Skin	29.4 nTPM
Adipose tissue	28.0 nTPM
Placenta	27.1 nTPM
Breast	26.4 nTPM
Prostate	23.4 nTPM
Esophagus	22.5 nTPM
Lung	21.2 nTPM
Stomach	17.8 nTPM

Intestinal goblet cells	50.2 nTPM
Colon	58.6 nTPM
Rectum	53.6 nTPM
Small intestine	38.3 nTPM

Macrophages	18.2 nTPM
Endometrium	33.4 nTPM
Skeletal muscle	30.3 nTPM
Lung	27.7 nTPM
Esophagus	25.2 nTPM
Ovary	22.7 nTPM
Adipose tissue	22.0 nTPM
Spleen	20.7 nTPM
Breast	20.7 nTPM
Stomach	17.6 nTPM
Bone marrow	15.0 nTPM
Prostate	10.3 nTPM
Pancreas	10.2 nTPM
Testis	9.2 nTPM
Kidney	7.6 nTPM
PBMC	0.0 nTPM

Paneth cells	27.1 nTPM
Colon	39.6 nTPM
Rectum	30.5 nTPM
Small intestine	11.3 nTPM

Plasma cells	54.2 nTPM
Stomach	71.1 nTPM
Spleen	62.7 nTPM
Bone marrow	57.7 nTPM
Esophagus	55.5 nTPM
Adipose tissue	23.9 nTPM

Respiratory ciliated cells	26.4 nTPM
Bronchus	35.2 nTPM
Lung	17.5 nTPM

Smooth muscle cells	27.7 nTPM
Heart muscle	70.2 nTPM
Endometrium	43.8 nTPM
Pancreas	32.4 nTPM
Ovary	31.3 nTPM
Skeletal muscle	24.3 nTPM
Adipose tissue	24.0 nTPM
Breast	19.7 nTPM
Skin	19.5 nTPM
Prostate	15.9 nTPM
Bronchus	12.2 nTPM
Esophagus	10.9 nTPM

T-cells	21.7 nTPM
Lung	36.5 nTPM
Endometrium	32.8 nTPM
Esophagus	32.8 nTPM
Skeletal muscle	32.6 nTPM
Breast	24.5 nTPM
Liver	24.2 nTPM
Adipose tissue	23.2 nTPM
Ovary	22.3 nTPM
Stomach	21.7 nTPM
Bone marrow	17.5 nTPM
PBMC	17.4 nTPM
Colon	16.6 nTPM
Spleen	16.1 nTPM
Skin	15.7 nTPM
Lymph node	15.5 nTPM
Kidney	10.2 nTPM
Prostate	9.5 nTPM

Basal prostatic cells	12.7 nTPM
Prostate	12.7 nTPM

Basal respiratory cells	17.0 nTPM
Bronchus	17.0 nTPM

Basal squamous epithelial cells	13.1 nTPM
Esophagus	13.1 nTPM

Cholangiocytes	8.6 nTPM
Liver	8.6 nTPM

Undifferentiated cells	32.5 nTPM
Colon	45.0 nTPM
Rectum	36.0 nTPM
Small intestine	16.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC